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Cells
Special Issues
Highlights in Red Blood Cell Research
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Highlights in Red Blood Cell Research

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 May 2024 | Viewed by 983

Special Issue Editors

Prof. Dr. Anna Bogdanova

E-Mail Website
Guest Editor
Red Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zürich, Switzerland
Interests: red blood cells; hypoxia; heterogeneity; redox signaling; anemia
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lars Kaestner

E-Mail Website
Guest Editor
Theoretical Medicine and Biosciences, Saarland University, Saarbruecken, Germany
Interests: red blood cells; ion channels; calcium signaling; microscopy; hematology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue welcomes articles exploring novel aspects of red blood cell research that address the following topics: (i) fundamental aspects of red blood cell structure and function; (ii) pathology associated with red blood cell disorders; (iii) red cell conservation, de novo production, and transfusion; and (iv) adaptation of red blood cells in humans and animals to environmental changes. We also welcome papers on novel technologies for studying red blood cells.

Prof. Dr. Anna Bogdanova
Prof. Dr. Lars Kaestner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • red blood cells
  • anemia
  • transfusion
  • erythropoiesis
  • signaling

Published Papers (1 paper)

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Research

24 pages, 5018 KiB  
Article
Hematin- and Hemin-Induced Spherization and Hemolysis of Human Erythrocytes Are Independent of Extracellular Calcium Concentration
by Diana M. Mikhailova, Elisaveta Skverchinskaya, Julia Sudnitsyna, Kirill R. Butov, Ekaterina M. Koltsova, Igor V. Mindukshev and Stepan Gambaryan
Cells 2024, 13(6), 554; https://doi.org/10.3390/cells13060554 - 21 Mar 2024
Viewed by 736
Abstract
Pathologies such as malaria, hemorrhagic stroke, sickle cell disease, and thalassemia are characterized by the release of hemoglobin degradation products from damaged RBCs. Hematin (liganded with OH−) and hemin (liganded with Cl−)—are the oxidized forms of heme with toxic [...] Read more.
Pathologies such as malaria, hemorrhagic stroke, sickle cell disease, and thalassemia are characterized by the release of hemoglobin degradation products from damaged RBCs. Hematin (liganded with OH−) and hemin (liganded with Cl−)—are the oxidized forms of heme with toxic properties due to their hydrophobicity and the presence of redox-active Fe3. In the present study, using the original LaSca-TM laser particle analyzer, flow cytometry, and confocal microscopy, we showed that both hematin and hemin induce dose-dependent RBC spherization and hemolysis with ghost formation. Hematin and hemin at nanomolar concentrations increased [Ca2+]i in RBC; however, spherization and hemolysis occurred in the presence and absence of calcium, indicating that both processes are independent of [Ca2+]i. Both compounds triggered acute phosphatidylserine exposure on the membrane surface, reversible after 60 min of incubation. A comparison of hematin and hemin effects on RBCs revealed that hematin is a more reactive toxic metabolite than hemin towards human RBCs. The toxic effects of heme derivatives were reduced and even reversed in the presence of albumin, indicating the presence in RBCs of the own recovery system against the toxic effects of heme derivatives. Full article
(This article belongs to the Special Issue Highlights in Red Blood Cell Research)
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