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Cells
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Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0
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Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2408

Special Issue Editors

Dr. Mohamed Mekhemar

E-Mail Website
Guest Editor
Clinic for Conservative Dentistry and Periodontology, University of Kiel, 24105 Kiel, Germany
Interests: periodontology; stem cells; regeneration; oral health
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Karim Mohamed Fawzy El-Sayed

E-Mail
Guest Editor
1. Clinic for Conservative Dentistry and Periodontology, University of Kiel, 24105 Kiel, Germany
2. Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
Interests: periodontal regeneration; progenitor cells; dentistry; stem cell biology

Special Issue Information

Dear Colleagues,

Mesenchymal stem cells (MSCs) are biological candidates for numerous applications in the fields of regenerative medicine and immunotherapy. Their multilineage differentiation ability and immune modulatory functions promote their application for disease management in different inflammatory, degenerative, and immunological conditions. However, the local cellular microenvironment and the MSC source can control miscellaneous biological features of these cells. The crosstalk between mesenchymal stem cells and numerous microenvironmental factors has been reported to endorse a variety of biological responses and functions. Stimulation or inhibition of MSC receptors and functions by the surrounding microenvironmental factors before or within potential treatment events may serve as an effective method to control the biological function of MSCs as needed in different therapeutic stages of the disease.

This Special Issue aims to be a collection of recent research on microenvironmental factors and functional modulation in mesenchymal stem cells.

We look forward to your contributions.

Dr. Mohamed Mekhemar
Prof. Dr. Karim Mohamed Fawzy El-Sayed
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesenchymal stem cells
  • inflammation
  • microenvironment
  • regeneration of mesenchymal stem cell receptors
  • stem cell differentiation

Related Special Issue

Published Papers (2 papers)

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Research

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16 pages, 3627 KiB  
Article
Effect of Hyperbaric Oxygen and Inflammation on Human Gingival Mesenchymal Stem/Progenitor Cells
by Johannes Tölle, Andreas Koch, Kristina Schlicht, Dirk Finger, Wataru Kaehler, Marc Höppner, Christian Graetz, Christof Dörfer, Dominik M. Schulte and Karim Fawzy El-Sayed
Cells 2023, 12(20), 2479; https://doi.org/10.3390/cells12202479 - 18 Oct 2023
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Abstract
The present study explores for the first time the effect of hyperbaric oxygen (HBO) on gingival mesenchymal stem cells’ (G-MSCs) gene expression profile, intracellular pathway activation, pluripotency, and differentiation potential under an experimental inflammatory setup. G-MSCs were isolated from five healthy individuals ( [...] Read more.
The present study explores for the first time the effect of hyperbaric oxygen (HBO) on gingival mesenchymal stem cells’ (G-MSCs) gene expression profile, intracellular pathway activation, pluripotency, and differentiation potential under an experimental inflammatory setup. G-MSCs were isolated from five healthy individuals (n = 5) and characterized. Single (24 h) or double (72 h) HBO stimulation (100% O2, 3 bar, 90 min) was performed under experimental inflammatory [IL-1β (1 ng/mL)/TNF-α (10 ng/mL)/IFN-γ (100 ng/mL)] and non-inflammatory micro-environment. Next Generation Sequencing and KEGG pathway enrichment analysis, G-MSCs’ pluripotency gene expression, Wnt-/β-catenin pathway activation, proliferation, colony formation, and differentiation were investigated. G-MSCs demonstrated all mesenchymal stem/progenitor cells’ characteristics. The beneficial effect of a single HBO stimulation was evident, with anti-inflammatory effects and induction of differentiation (TLL1, ID3, BHLHE40), proliferation/cell survival (BMF, ID3, TXNIP, PDK4, ABL2), migration (ABL2) and osteogenic differentiation (p < 0.05). A second HBO stimulation at 72 h had a detrimental effect, significantly increasing the inflammation-induced cellular stress and ROS accumulation through HMOX1, BHLHE40, and ARL4C amplification and pathway enrichment (p < 0.05). Results outline a positive short-term single HBO anti-inflammatory, regenerative, and differentiation stimulatory effect on G-MSCs. A second (72 h) stimulation is detrimental to the same properties. The current results could open new perspectives in the clinical application of short-termed HBO induction in G-MSCs-mediated periodontal reparative/regenerative mechanisms. Full article
(This article belongs to the Special Issue Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0)
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Review

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38 pages, 4189 KiB  
Review
PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche
by Hanghang Liu, Linyi Liu and Clifford J. Rosen
Cells 2024, 13(5), 406; https://doi.org/10.3390/cells13050406 - 26 Feb 2024
Cited by 1 | Viewed by 1037
Abstract
Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely by modulating bone remodeling processes. Its effects on bone are notably dependent on the duration and frequency of exposure. Specifically, PTH can initiate both bone formation and resorption, with the outcome [...] Read more.
Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely by modulating bone remodeling processes. Its effects on bone are notably dependent on the duration and frequency of exposure. Specifically, PTH can initiate both bone formation and resorption, with the outcome being influenced by the manner of PTH administration: continuous or intermittent. In continuous administration, PTH tends to promote bone resorption, possibly by regulating certain genes within bone cells. Conversely, intermittent exposure generally favors bone formation, possibly through transient gene activation. PTH’s role extends to various aspects of bone cell activity. It directly influences skeletal stem cells, osteoblastic lineage cells, osteocytes, and T cells, playing a critical role in bone generation. Simultaneously, it indirectly affects osteoclast precursor cells and osteoclasts, and has a direct impact on T cells, contributing to its role in bone resorption. Despite these insights, the intricate mechanisms through which PTH acts within the bone marrow niche are not entirely understood. This article reviews the dual roles of PTH—catabolic and anabolic—on bone cells, highlighting the cellular and molecular pathways involved in these processes. The complex interplay of these factors in bone remodeling underscores the need for further investigation to fully comprehend PTH’s multifaceted influence on bone health. Full article
(This article belongs to the Special Issue Microenvironmental Factors and Functional Modulation in Mesenchymal Stem Cells 2.0)
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