Human Dental Pulp Stem Cells: Isolation, Cultivation and Applications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1640
Special Issue Editor
Interests: dental pulp stem cell-mediated inferior alveolar nerve regeneration; reparative dentin formation; engineering stem cells by CRISPR and siRNA; microenvironmentally modified stem cell; complement C5a receptors in regeneration
Special Issue Information
Dear Colleagues,
Dental pulp stem cells (DPSCs) are a relatively new source of mesenchymal stem cells. They reside within the dental pulp of immature human teeth and possess a great ability to differentiate into odontoblast-like cells that can regenerate a dentin–pulp complex. DPSCs also play an important role in regeneration medicine with their unique properties and advantages. For example, they are derived from the neural crest with strong expression of neuronal marker molecules and neurotransmitter receptors which suggests that DPSCs can actively adapt to the neuronal environment. Several studies demonstrated that DPSCs show better neuroregeneration and protective ability than bone marrow-derived mesenchymal cells. Furthermore, DPSCs are relatively easy to obtain through a minimally invasive procedure in adults and children without raising ethical issues. These characteristics make DPSCs an ideal stem cell source for clinical regeneration medicine. However, they have been given relatively less attention compared to other stem cell types, such as neural stem cells and induced pluripotent stem cells, that leave many of their unique functions undetermined. Understanding the biological mechanisms of DPSCs and their clinical applications is required for successful DPSC engineering strategies. The scientific knowledge obtained from this Special Issue will provide an important basis for future studies and for creating therapeutic tools that target DPSC in regenerative medicine.
Dr. Seung Chung
Guest Editor
Manuscript Submission Information
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Keywords
- dental pulp stem cell
- stem cell engineering
- mesenchymal stem cell
- detin-pulp complex regeneration
- dentinogenesis
- odontoblastic dental pulp stem cell regeneration
- dental pulp stem cell in neural regeneration
