Cellular and Molecular Mechanisms of Cancer Metastasis—2nd Edition

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 261

Special Issue Editor


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Guest Editor
Head of EXTRO-Lab, Dept. of Therapeutic Radiology and Oncology, Tyrolean Cancer Research Institute, Medical University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria
Interests: cancer metastasis; cancer stem cells; therapy resistance; molecular mechanisms; cancer microenvironment
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Special Issue Information

Dear Colleagues,

Malignant tumors are characterized by the abilities to metastasize, and metastatic spread results in unfavorable prognosis and treatment outcomes. Although metastasis-related pathways are under intensive investigations, the background for the tumor susceptibility to metastasis is still poorly understood. It is also not well known whether carcinoma cells with enhanced metastatic properties reveal an affected treatment sensitivity compared to other malignant cells.

Under current discussion is the fact that a number of specific cellular properties (enhanced invasive and migratory abilities, increased expression of the molecules associated with metastatic spread, metabolic alterations resulting in the enhancement of cancer cell aggressiveness, etc.) and microenvironmental factors (crosstalk between malignant and nonmalignant cells comprising tumors, cytokine and growth factor release by the cells, proinflammatory stimuli, etc.) can contribute to metastatic spread and limit therapy responses.

It is proposed that the following aspects of the subject area be highlighted in this Special Issue:

  • The role of dormancy in metastasis development;
  • Cancer stem cells as a root for metastasis formation;
  • The molecular properties of tumor cells with enhanced metastatic capacities;
  • The molecular mechanisms of organ-specific metastasis;
  • Circulating tumor cells;
  • Therapy-induced metastasis;
  • Tumor metabolism and metastatic spread;
  • The role of the microenvironment (tumor stroma and immune system) in metastatic progression;
  • Exosomes in disease progression;
  • Cytokines contributing to metastatic spread;
  • Metabolic hallmarks of metastasis formation;
  • Diagnostic tools for metastasis detection;
  • Therapeutic approaches to combating metastatic progression.

Prof. Dr. Ira-Ida Skvortsova
Guest Editor

Manuscript Submission Information

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Related Special Issue

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Novel high-throughput screen identified S100A4 inhibitors for anti-metastatic therapy
Authors: Paul Curtis Schöpe *1, Nina Heisterkamp*1, Devin Schütz*1, Kerstin Putzker2, Ulrike Uhrig2, Wolfgang Walther1, Dennis Kobelt1, Ulrike Stein1,3
Affiliation: 1 Experimental and Clinical Research Center, Charité – Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13125 Berlin, Germany 2 The European Molecular Biology Laboratory, EMBL, Meyerhofstraße 1, 69120, Heidelberg, Germany 3 German Cancer Consortium (DKTK Partnersite Berlin), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany * contributed equally
Abstract: N/A

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