Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 5 December 2024 | Viewed by 308
Special Issue Editors
Interests: cancer metastasis; cancer stem cells; therapy resistance; molecular mechanisms; cancer microenvironment
Special Issues, Collections and Topics in MDPI journals
2. Department of Medical Humanities and Education, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Interests: cancer comorbidity; cancer treatment complication; cancer prognosis; public health
Special Issues, Collections and Topics in MDPI journals
Interests: radiotherapy and combination therapy in cancer; image guidance; biomarker; palliative care; IMRT; VMAT; IGRT; tomotherapy; SMART
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The interactions between cells in the ecosystem where a tumor resides contribute to cancer cell progression, invasion, and metastasis. In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, highlighting the importance of a fertile environment for the tumor cells to grow. Tumor-infiltrating cells, mainly immune cells, produce inflammatory mediators to form a microenvironment promoting cancer development and progression. Mounting evidence from preclinical studies and clinical trials have shown that the combination of immune-checkpoint blockade and radiation therapy (RT) result in a synergy.
With the advent of immunotherapy and innovative imaging technology, more abscopal effects upon RT in combination with immune-checkpoint inhibition have been reported. An abscopal effect is an appealing phenomenon after RT activates the antitumor immune response, and was described as early as 1953. From a molecular standpoint, RT causes not only direct DNA damage but also ample reactive-oxygen-species-dependent damage to DNA, potentially culminating in the permanent inactivation of cell division, cellular senescence, or the initiation of cell death programs. While many recent studies clearly attribute the abscopal effect to the activation of the immune system against cancer cells, the cellular and molecular mechanisms remain mysterious.
We welcome in-depth reviews and original articles from the latest research on multi-modality treatment strategies (chemotherapy, immunotherapy, and targeted therapy combined with RT) addressing the roles and interactions of the abscopal effect, micro-environmental factors, radiosensitizers, ground-breaking RT technology, and natural food extracts to overcome treatment complications, as well as biomarkers for predicting RT outcome.
You may choose our Joint Special Issue in Cells.
Prof. Dr. Ira-Ida Skvortsova
Dr. Johjong Huang
Dr. Hsin-Hua Lee
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor microenvironment
- natural food extracts
- molecular markers
- abscopal effect
- RT technology
- prognosis
- side effects and abscopal effects
