Selected Papers from the Champalimaud Symposium "Physiology: from Development to Disease"

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (10 December 2017) | Viewed by 6494

Special Issue Editor


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Guest Editor
Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal
Interests: cell competition processes in drosophila; mouse and humans; cell competition in relation to neurobiology; tumorigenesis and aging stem cell niches; evolution of cell competition in multicellular organisms

Special Issue Information

Dear Colleagues,

The 2017 Champalimaud Research Symposium, with the theme “Physiology: From Development to Disease” will be held in Lisbon, Portugal, 9–11 October, 2017. The Symposium will be a single-track scientific meeting with 14 invited speakers.  It will focus on modern physiology in development, aging, immunity and cancer, bridging cutting edge biology research with disease oriented research, and will feature a keynote lecture from Professor Bob Horvitz, winner of the 2002 Prize in Physiology or Medicine, shared with Sydney Brenner and John Sulston, “for their discoveries concerning genetic regulation of organ development and programmed cell death”.

This symposium is a very special event, as it will serve as the inaugural conference to launch the Champalimaud Biology of Systems and Metastasis Research Program. This new research program, together with the neuroscience program, aims at establishing the Champalimaud Centre for the Unknown as a premier biomedical research effort. After five successful neuroscience symposia, it is a great pleasure to commence this new phase of the Champalimaud Research with what promises to be this exciting and rewarding symposium. The diverse list of distinguished speakers will reflect the vision for our research.

The symposium will be held at our centre on the stunning waterfront in Lisbon, and will also feature a social program that will give participants the chance to explore this beautiful and historic city. We expect that the unique venue, together with the exciting list of invited speakers, will foster a lively and stimulating scientific meeting.

For all details please see https://symposium.research.fchampalimaud.org/, where the full list of presenters is available.

Participants of the conference are cordially invited to contribute original research papers or reviews to this Special Issue of Cells. All the papers will be peer-reviewed according to the standard procedure of Cells. Five feature papers fully free of charge, and for other papers 20% discount from the standard Article Processing Charge (APC) are provided.

Dr. Eduardo Moreno
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

12 pages, 2707 KiB  
Communication
Identification of Novel Hemangioblast Genes in the Early Chick Embryo
by José Serrado Marques, Vera Teixeira, António Jacinto and Ana Teresa Tavares
Cells 2018, 7(2), 9; https://doi.org/10.3390/cells7020009 - 31 Jan 2018
Cited by 2 | Viewed by 6048
Abstract
During early vertebrate embryogenesis, both hematopoietic and endothelial lineages derive from a common progenitor known as the hemangioblast. Hemangioblasts derive from mesodermal cells that migrate from the posterior primitive streak into the extraembryonic yolk sac. In addition to primitive hematopoietic cells, recent evidence [...] Read more.
During early vertebrate embryogenesis, both hematopoietic and endothelial lineages derive from a common progenitor known as the hemangioblast. Hemangioblasts derive from mesodermal cells that migrate from the posterior primitive streak into the extraembryonic yolk sac. In addition to primitive hematopoietic cells, recent evidence revealed that yolk sac hemangioblasts also give rise to tissue-resident macrophages and to definitive hematopoietic stem/progenitor cells. In our previous work, we used a novel hemangioblast-specific reporter to isolate the population of chick yolk sac hemangioblasts and characterize its gene expression profile using microarrays. Here we report the microarray profile analysis and the identification of upregulated genes not yet described in hemangioblasts. These include the solute carrier transporters SLC15A1 and SCL32A1, the cytoskeletal protein RhoGap6, the serine protease CTSG, the transmembrane receptor MRC1, the transcription factors LHX8, CITED4 and PITX1, and the previously uncharacterized gene DIA1R. Expression analysis by in situ hybridization showed that chick DIA1R is expressed not only in yolk sac hemangioblasts but also in particular intraembryonic populations of hemogenic endothelial cells, suggesting a potential role in the hemangioblast-derived hemogenic lineage. Future research into the function of these newly identified genes may reveal novel important regulators of hemangioblast development. Full article
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