New Insights into Vascular Biology in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1537
Special Issue Editor
Interests: experimental and cellular therapeutics; the mechanisms of cardiovascular and inflammatory diseases, including but not limited to atherosclerosis, cancer and vascular complications
Special Issue Information
Dear Colleagues,
Vascular biology is crucial for understanding the mechanisms behind vascular diseases in the context of cardiovascular conditions, atherosclerosis, and cancer, as well as developing effective treatments and preventive strategies. Hyperhomocysteinemia is considered to be a major risk factor for multiple diseases. These include, but are not limited to, cardiovascular disease, stroke, diabetes, obesity, hypertension, renal failure, cancer, dementia, Alzheimer's, osteoporosis, and neurological disorders. The progression of vascular diseases is a multifactorial process, including endothelial dysfunction, vascular smooth muscle cell apoptosis, proliferation, and migration from the media to the intima. Under physiological conditions, cell proliferation and apoptosis are balanced since cell death triggers cell migration and proliferation. However, in pathogenic conditions, a selective increase in cell proliferation induces hyperplasia, and a selective elevation of apoptosis leads to atrophy. Autophagy has emerged in recent years as a critical cellular survival mechanism for cell homeostasis and may play a protective role in atherosclerosis. In lipid-rich atherosclerotic areas, angiogenesis is often associated with inflammatory cells that play a role in plaque instability and rupture. Furthermore, neovascularization is a prominent feature in advanced human atherosclerotic plaques and cancer.
The objective of this Special Issue is to spotlight recent discoveries related to autophagy, hyperhomocyteinemia, alcohols, and galectins in the progression of vascular diseases and the effective therapeutic targets.
Dr. Bashir M. Rezk
Guest Editor
Manuscript Submission Information
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Keywords
- vascular diseases
- cardiovascular
- cancer
- hyperhomocyteinemia
- endothelial dysfunction
- vascular smooth muscle cell
- autophagy
- alcohol
- galectins
- angiogenesis
- neovascularization
