Mucosal Immunity and Epithelial Barrier Biology: From Tissue Homeostasis to Chronic Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 237
Special Issue Editors
Interests: mucosal immunology; respiratory medicine; allergy and pulmonary diseases; IgA; lung epithelium biology
Special Issues, Collections and Topics in MDPI journals
Interests: dermatology; allergology; immunology
2. Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium
Interests: gut immunity; intestinal epithelial barrier; intestinal immunity; hepatology; gastroenterology; alcoholology
Special Issue Information
Dear Colleagues,
The airways, from the nose to the deep pulmonary alveoli, the gut, and the skin are directly exposed to external matters, leading to a challenge for those epithelial barriers and the immune system to prevent unnecessary responses and to adapt their response to noxious or harmless exposures. Homeostasis at mucosal and skin barriers involves a complex interplay between structural and immune cells, an emerging concept being the “memory” of previous responses that is developed not only in immune cells but also in epithelial stem cells. Several diseases, such as chronic rhinosinusitis, asthma, colitis and allergic dermatitis are typically linked with aberrant cell responses to external matters. They share longstanding histories of repeated exposure-repair cycles over years that may cause alterations in organ development, epithelial-mesenchymal unit biology as well as chronic immune activation. Altered mucosal immunity (notably its major mediator, namely IgA) integrates the pathophysiology of such chronic diseases and could reflect an abnormal interplay with the gut/lung microbiome in chronic disease. Early dysregulation of mucosal barriers may also imprint barrier tissues during childhood to promote future disease development. The studies of mucosal and skin (dys)immunity that consider both cross-organ similarities and specificities, should provide in the future valuable targets for preventive or therapeutic interventions in order to tackle pathogenic mechanisms before irreversible changes feed the roots of chronic disease.
Prof. Dr. Charles Pilette
Prof. Dr. Marie Baeck
Prof. Dr. Peter Stärkel
Guest Editors
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Keywords
- epithelial barrier
- mucosal immunity
- immune system
- skin barrier
- skin immunity
- IgA
- chronic disease
- airways
- respiratory
- lung
- gut
- skin
- therapeutic interventions
