Role of DNA Repeats in Shaping Genome Structure and Gene Regulatory Networks
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 346
Interests: leukemias; breast cancer; chromatin; DNA damage; genomic-instability; metastasis; genomics; mutations
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Repetitive sequences, including transposable elements, and simple repeats constitute at least half of the mouse and human genomes. The most abundant subclasses are the short interspersed nuclear elements (SINEs; 1.4 million copies of human Alu elements or 0,6 millions of mouse B1 repeats) and the long interspersed element-1 (LINE1 or L1; 1.0 million copies in the human and mouse genomes).
Once considered as junk or “parasite” DNA, it is now recognized that repetitive sequences regulate chromatin organization, the 3D structure of the genome, and transcription of specific gene subsets at both transcriptional and post-transcriptional levels. Emerging evidence suggests that their activity influences fundamental cell processes, including inflammation, senescence, genome stability and DNA damage, and is implicated in cancer development and aging.
Topics of interest may include:
- How repetitive sequences shape genome structure and/or gene regulatory networks within their host genome;
- The role of individual repeat subfamilies in gene regulation;
- The role of repetitive sequences in the regulation of fundamental cell processes;
- The role of repetitive sequence in cancer and aging.
Prof. Dr. Pier Giuseppe Pelicci
Dr. Gaetano Ivan Dellino
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- repetitive sequences
- DNA damage
- genome structure
- gene regulatory networks
- cell processes
- cancer and aging