Cross-Talk between Metabolic and Mechanical Factors Regulating Cell Growth, Differentiation and Homeostasis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (16 July 2022) | Viewed by 438
Special Issue Editor
Interests: muscle physiology; mechanobiology; muscle disorders; satellite cells; cell signaling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mechanical forces are sensed through mechanosensing receptors and translate into signaling pathways that elicit biological responses. This process, known as mechanotransduction, is fundamental for cell and tissue growth, maintenance, and function. Cell metabolism has recently emerged as one of the cell processes regulated by mechanical forces exerted by the extracellular matrix (ECM), cell–ECM, and cell–cell adhesion complexes or generated by cells themselves. Alternatively, cell metabolism is critical to regulating the mechanical properties of cells and tissues. This Special Issue aims to provide a comprehensive overview of the state of the art of the crosstalk between mechanotransduction and cell metabolism. We invite research papers that will consolidate our understanding in this broad area. The Special Issue will publish full research articles and comprehensive reviews. Potential topics include but are not limited to the following research areas:
- Influences of mechanical forces on metabolic processes, including mitochondrial shape, energy sensors, activation/inactivation of proteins including metabolic enzymes, or lipid synthesis;
- Metabolic regulations via YAP/TAZ dependent mechanotransduction;
- Metabolic regulations via cell adhesion complexes and mechanical environment;
- Influences of shear stress, compression or stretching on the regulatory mechanisms linking metabolism and mechanics;
- Novel methodologies including 3D tissue engineering techniques and novel instrumental/computational advances to study the interactions between cell/tissue mechanics and metabolism.
Dr. Catherine Coirault
Guest Editor
Manuscript Submission Information
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Keywords
- mechanotransduction
- mechanical forces
- cell adhesion
- extracellular matrix
- glycolytic metabolism
- lipid metabolism
- nutrient sensing
