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Cellular and Molecular Mechanisms of Bone Metastases
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Cellular and Molecular Mechanisms of Bone Metastases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".

Deadline for manuscript submissions: closed (1 July 2022) | Viewed by 15531

Special Issue Editor

Dr. Khalid Said Mohammad

E-Mail Website
Guest Editor
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: bone metastases; breast cancer; TGF-beta; histomorphometry; animal model

Special Issue Information

Dear Colleagues,

This Special Issue will investigate the mechanisms responsible for bone metastases and cancer cell interaction with the bone microenvironment and how dormant cancer cells promote metastases. The issue will also explore the possible therapeutic approaches based on understanding the metastatic process.

The Special Issue will focus on understanding the mechanism by which circulating tumors can colonize the bone. The unique bone microenvironment is considered a preferred site of metastases for certain solid tumors as predicted through the “seed and soil” theory by Dr. Stephen Paget, which influences tumor growth. The Special Issue will also examine why dormant cancer cells constitute a significant issue in bone metastases and how different types of cancer can interact with the bone microenvironment and triggers different bone responses. Understanding the mechanisms by which the bone can become more hospitable to cancer cells under specific disease processes or treatments and a clear understanding of the process of metastases can affect our ability to develop effective treatments.

Dr. Khalid Said Mohammad
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone microenvironment
  • cancer
  • metastases
  • bone remodeling
  • osteoblast
  • osteoclast

Published Papers (4 papers)

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Review

18 pages, 706 KiB  
Review
Bone Disease in Multiple Myeloma: Biologic and Clinical Implications
by Zachary S. Bernstein, E. Bridget Kim and Noopur Raje
Cells 2022, 11(15), 2308; https://doi.org/10.3390/cells11152308 - 27 Jul 2022
Cited by 12 | Viewed by 4626
Abstract
Multiple Myeloma (MM) is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells localized within the bone marrow. Bone disease with associated osteolytic lesions is a hallmark of MM and develops in the majority of MM patients. Approximately half of patients [...] Read more.
Multiple Myeloma (MM) is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells localized within the bone marrow. Bone disease with associated osteolytic lesions is a hallmark of MM and develops in the majority of MM patients. Approximately half of patients with bone disease will experience skeletal-related events (SREs), such as spinal cord compression and pathologic fractures, which increase the risk of mortality by 20–40%. At the cellular level, bone disease results from a tumor-cell-driven imbalance between osteoclast bone resorption and osteoblast bone formation, thereby creating a favorable cellular environment for bone resorption. The use of osteoclast inhibitory therapies with bisphosphonates, such as zoledronic acid and the RANKL inhibitor denosumab, have been shown to delay and lower the risk of SREs, as well as the need for surgery or radiation therapy to treat severe bone complications. This review outlines our current understanding of the molecular underpinnings of bone disease, available therapeutic options, and highlights recent advances in the management of MM-related bone disease. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastases)
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28 pages, 1518 KiB  
Review
Translational Strategies to Target Metastatic Bone Disease
by Gabriel M. Pagnotti, Trupti Trivedi and Khalid S. Mohammad
Cells 2022, 11(8), 1309; https://doi.org/10.3390/cells11081309 - 12 Apr 2022
Cited by 4 | Viewed by 2171
Abstract
Metastatic bone disease is a common and devastating complication to cancer, confounding treatments and recovery efforts and presenting a significant barrier to de-escalating the adverse outcomes associated with disease progression. Despite significant advances in the field, bone metastases remain presently incurable and contribute [...] Read more.
Metastatic bone disease is a common and devastating complication to cancer, confounding treatments and recovery efforts and presenting a significant barrier to de-escalating the adverse outcomes associated with disease progression. Despite significant advances in the field, bone metastases remain presently incurable and contribute heavily to cancer-associated morbidity and mortality. Mechanisms associated with metastatic bone disease perpetuation and paralleled disruption of bone remodeling are highlighted to convey how they provide the foundation for therapeutic targets to stem disease escalation. The focus of this review aims to describe the preclinical modeling and diagnostic evaluation of metastatic bone disease as well as discuss the range of therapeutic modalities used clinically and how they may impact skeletal tissue. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastases)
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Figure 1

19 pages, 2698 KiB  
Review
Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems
by Huimin Shao and Pegah Varamini
Cells 2022, 11(3), 388; https://doi.org/10.3390/cells11030388 - 24 Jan 2022
Cited by 15 | Viewed by 5340
Abstract
Bone is one of the most common metastatic sites among breast cancer (BC) patients. Once bone metastasis is developed, patients’ survival and quality of life will be significantly declined. At present, there are limited therapeutic options for BC patients with bone metastasis. Different [...] Read more.
Bone is one of the most common metastatic sites among breast cancer (BC) patients. Once bone metastasis is developed, patients’ survival and quality of life will be significantly declined. At present, there are limited therapeutic options for BC patients with bone metastasis. Different nanotechnology-based delivery systems have been developed aiming to specifically deliver the therapeutic agents to the bone. The conjugation of targeting agents to nanoparticles can enhance the selective delivery of various payloads to the metastatic bone lesion. The current review highlights promising and emerging advanced nanotechnologies designed for targeted delivery of anticancer therapeutics, contrast agents, photodynamic and photothermal materials to the bone to achieve the goal of treatment, diagnosis, and prevention of BC bone metastasis. A better understanding of various properties of these new therapeutic approaches may open up new landscapes in medicine towards improving the quality of life and overall survival of BC patients who experience bone metastasis. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastases)
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Graphical abstract

16 pages, 3086 KiB  
Review
Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis
by Jang Bae Moon, Su Woong Yoo, Changho Lee, Dong-Yeon Kim, Ayoung Pyo and Seong Young Kwon
Cells 2021, 10(11), 2877; https://doi.org/10.3390/cells10112877 - 25 Oct 2021
Cited by 1 | Viewed by 2665
Abstract
Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME [...] Read more.
Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Bone Metastases)
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