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Cells
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The Role of Natural Extracts and Phytochemicals in the Treatment...
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The Role of Natural Extracts and Phytochemicals in the Treatment of Chronic Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1287

Special Issue Editors

Dr. Daniela Carlisi

E-Mail Website
Guest Editor
Department of Biomedicine, Neurosciences and Advanced Diagnostics (BIND), Institute of Biochemistry, University of Palermo, Via del Vespro, 131, 90127 Palermo, Italy
Interests: breast cancer; chemotherapy resistance; cancer stem cells; NAFLD; natural drugs
Special Issues, Collections and Topics in MDPI journals
Dr. Anna De Blasio

E-Mail Website
Guest Editor
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), Laboratory of Biochemistry, University of Palermo, Viale delle Scienze, ed. 16, 90128 Palermo, Italy
Interests: TNBC; miRNA; cell death; cancer stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The plant world is one of the main sources of active molecules used by researchers to find useful strategies to combat various chronic diseases. Phytochemicals are generally low-molecular-weight organic compounds produced by the primary and secondary metabolisms of plants. They frequently possess anti-inflammatory, antioxidant, and anticancer properties.

The purpose of this Special Issue is to collect original articles or reviews regarding the effects of natural extracts, such as essential oils and phytochemicals, or natural extracts in general, in relation to the following topics:

  • Antitumor and/or protective effects in in vitro and in vivo models, with identification of the biochemical pathways involved;
  • Antioxidant activity for rheumatoid pathologies;
  • Antilipogenetic lipolytic activity, in order to counteract obesity and pathologies related to metabolic syndrome (hepatic steatosis, non-alcoholic, and insulin resistance);
  • Food intolerances related to chronic pathologies (e.g., celiac disease).

Dr. Daniela Carlisi
Dr. Anna De Blasio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

18 pages, 4230 KiB  
Article
Positive Impacts of Aphanizomenon Flos Aquae Extract on Obesity-Related Dysmetabolism in Mice with Diet-Induced Obesity
by Simona Terzo, Pasquale Calvi, Marta Giardina, Giacoma Gallizzi, Marta Di Carlo, Domenico Nuzzo, Pasquale Picone, Roberto Puleio, Flavia Mulè, Stefano Scoglio and Antonella Amato
Cells 2023, 12(23), 2706; https://doi.org/10.3390/cells12232706 - 25 Nov 2023
Viewed by 1005
Abstract
The present study evaluated the ability of KlamExtra®, an Aphanizomenon flos aquae (AFA) extract, to counteract metabolic dysfunctions due to a high fat diet (HFD) or to accelerate their reversion induced by switching an HFD to a normocaloric diet in mice [...] Read more.
The present study evaluated the ability of KlamExtra®, an Aphanizomenon flos aquae (AFA) extract, to counteract metabolic dysfunctions due to a high fat diet (HFD) or to accelerate their reversion induced by switching an HFD to a normocaloric diet in mice with diet-induced obesity. A group of HFD mice was fed with an HFD supplemented with AFA (HFD-AFA) and another one was fed with regular chow (standard diet—STD) alone or supplemented with AFA (STD-AFA). AFA was able to significantly reduce body weight, hypertriglyceridemia, liver fat accumulation and adipocyte size in HFD mice. AFA also reduced hyperglycaemia, insulinaemia, HOMA-IR and ameliorated the glucose tolerance and the insulin response of obese mice. Furthermore, in obese mice AFA normalised the gene and the protein expression of factors involved in lipid metabolism (FAS, PPAR-γ, SREBP-1c and FAT-P mRNA), inflammation (TNF-α and IL-6 mRNA, NFkB and IL-10 proteins) and oxidative stress (ROS levels and SOD activity). Interestingly, AFA accelerated the STD-induced reversion of glucose dysmetabolism, hepatic and VAT inflammation and oxidative stress. In conclusion, AFA supplementation prevents HFD-induced dysmetabolism and accelerates the STD-dependent recovery of glucose dysmetabolism by positively modulating oxidative stress, inflammation and the expression of the genes linked to lipid metabolism. Full article
(This article belongs to the Special Issue The Role of Natural Extracts and Phytochemicals in the Treatment of Chronic Diseases)
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