Special Issue "Novel Insights into the Role of Mitochondria in Neuropsychiatric and Neurodegenerative Disorders"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: 30 November 2023 | Viewed by 200

Special Issue Editor

1. Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-531 Coimbra, Portugal
2. Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal
Interests: neurons; mitochondria; calcium homeostasis; cell death; neurodegenerative disorders

Special Issue Information

Dear Colleagues,

Defects in mitochondrial function, dynamics and/or degradation have been largely described in defining the pathological mechanisms of several neurodegenerative disorders. Other evidence reports pre-symptomatic and early stage changes in different mitochondrial pathways, including redox modulation, mitochondrial quality control or the crosstalk with other organelles, as well as the transport of mitochondrial components between brain cells, revealing additional cellular mechanisms through which these “neuro-essential” organelles may be affected. Furthermore, many of these aspects have also been suggested to occur in different (neuro) psychiatric diseases, while various neurodegenerative diseases encompass early psychiatric symptoms. Neurodegenerative disorders include diverse clinical and pathological pathologies, characterized by progressive symptomatology, affecting selective brain areas and leading to cognitive decline, as well as the loss of memory and daily life functions. On the other hand, neuropsychiatric disorders encompass different mental diseases for which a fundamental neurobiological understanding has been suggested to explain behavioral development. Unfortunately, there is still no cure or neuroprotective treatments for these debilitating neuropsychiatric and neurodegenerative diseases, which supports the need for urgently identifying early diagnosis indicators and novel therapeutic targets and strategies for preventing or delaying the progression of these brain diseases.

This issue aims to cover the different aspects through which mitochondria may play a relevant role in both neuropsychiatric and neurodegenerative disorders.

Dr. Ana Cristina Rego
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondria
  • redox changes
  • autophagy
  • therapies
  • brain
  • exossomes
  • intercellular transport
  • mitophagy
  • mitochondrial quality control
  • mitochondria-associated membrane
  • psychiatric diseases
  • synapses
  • mitochondrial transport
  • neurodegeneration
  • synaptic dysfunction

Published Papers

This special issue is now open for submission.
Back to TopTop