Immunopharmacology: Current Applications and Future Perspectives

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1935

Special Issue Editors


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Guest Editor
Molecular and Cellular Gastroenterology, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain
Interests: inflammation; immune-mediated diseases; inflammatory bowel disease; colorectal cancer; resolution of inflammation
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Guest Editor
Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Interests: immunology; synthetic biology; medical oncology; metabolic engineering; protein engineering; drug discovery and development

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Guest Editor
Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Interests: immunotherapy; cardiovascular immunology; drug discovery; molecular biology; genetic engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunopharmacology focuses on the selective control of immune responses and explores advantageous therapeutic alternatives for both conventional and atypical-immune-system-derived clinical conditions. New classes of medications are being introduced as a result of substantial biotechnological developments and progression in acquired knowledge of the immune system. Recent immunopharmacological advancements have resulted in the expansion of clinically relevant drugs that selectively modulate the immune response in a variety of human pathologies, including but not limited to infectious diseases, cancer, chronic inflammatory diseases, cardiovascular disorders, neurological disorders, metabolic disorders, and skeletal disorders. Researchers and physicians in the domains of immunology, pharmacology, and drug discovery must prioritize increasing the efficacy and safety of currently available agents despite the imminent introduction of several novel compounds. In this context, a great deal of research aims at finding interconnections between pharmacology and immunology (and related fields such as immunotoxicology and immunogenetics). All types of immunomodulatory drugs, ranging from small molecules to vaccines and other biological modifiers, are the focus of this Special Issue, which attempts to present the state-of-the-art notions and future perspectives centered on the function of immunopharmacology in the field of therapeutics.

We cordially encourage all researchers to take part in this Special Issue. We welcome the submission of original research, reviews, or shorter perspectives on any topic relevant to immunopharmacology studies. The theme surrounds novel molecular and cellular functions of the key players in immunopharmacology, including novel approaches, advancements in current clinical scenarios, and newly emerging immunomodulators on various types of human pathologies. We particularly encourage the submission of articles on the functional characterization of novel rational medication combinations involving immunomodulators. Moreover, special emphasis will be placed on the causes and consequences of immunotherapy as a treatment for various diseases. Additionally, relevant ideas include single and combined drug therapies, the identification of novel mechanisms for drug-targeting therapies, and the creation of new logical drug combinations.

Dr. Javier Conde Aranda
Dr. Vishakha Anand Pawar
Dr. Vinay Kumar
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • immunotherapy
  • immunopharmacology
  • human diseases

Published Papers (1 paper)

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Review

48 pages, 1090 KiB  
Review
Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use
by Francesca Conti, Mattia Moratti, Lucia Leonardi, Arianna Catelli, Elisa Bortolamedi, Emanuele Filice, Anna Fetta, Marianna Fabi, Elena Facchini, Maria Elena Cantarini, Angela Miniaci, Duccio Maria Cordelli, Marcello Lanari, Andrea Pession and Daniele Zama
Cells 2023, 12(19), 2417; https://doi.org/10.3390/cells12192417 - 07 Oct 2023
Cited by 1 | Viewed by 1563
Abstract
Background: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-related immune dysregulation disorders, according to labelled and [...] Read more.
Background: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-related immune dysregulation disorders, according to labelled and off-label indications. Recent years have been dominated by a progressive imbalance between the gradual but constant increase in the use of immunoglobulins and their availability, exacerbated by the SARS-CoV-2 pandemic. Objectives: To provide pragmatic indications for a need-based application of high-dose immunoglobulins in the pediatric context. Sources: A literature search was performed using PubMed, from inception until 1st August 2023, including the following keywords: anti-inflammatory; children; high dose gammaglobulin; high dose immunoglobulin; immune dysregulation; immunomodulation; immunomodulatory; inflammation; intravenous gammaglobulin; intravenous immunoglobulin; off-label; pediatric; subcutaneous gammaglobulin; subcutaneous immunoglobulin. All article types were considered. Implications: In the light of the current imbalance between gammaglobulins’ demand and availability, this review advocates the urgency of a more conscious utilization of this medical product, giving indications about benefits, risks, cost-effectiveness, and administration routes of high-dose immunoglobulins in children with hematologic, neurologic, and inflammatory immune dysregulation disorders, prompting further research towards a responsible employment of gammaglobulins and improving the therapeutical decisional process. Full article
(This article belongs to the Special Issue Immunopharmacology: Current Applications and Future Perspectives)
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