Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 155
Special Issue Editors
2. Clinical and Experimental Medicine Ph.D. Program, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: neurodegenerative disorders; biomarkers; amyotrophic lateral sclerosis; genetics; clinical trials
2. Department of Neurosciences, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy
Interests: neurodegenerative disorders; amyotrophic lateral sclerosis; biomarkers; genetics; clinical trials; epidemiology
Special Issue Information
Dear Colleagues,
Motor neuron diseases are a heterogeneous group of disorders that are implicated in the relentless degeneration of the motor system, leading to upper and lower motor neuron excitotoxicity, muscle atrophy, paralysis and finally death. Despite intensive molecular and clinical research, their etiology remains largely unclear. Recent advancements in molecular biology and genetics have provided valuable insights into the pathogenesis of motor neuron diseases, paving the way for the development of targeted therapies that aim to slow or control the key causative processes.
Several mechanisms common to motor neuron disorders have been identified; these include excitotoxicity; abnormal intracellular and mitochondrial metabolism caused by the accumulation of oxidative species; a disturbed protein quality control system caused by the accumulation of misfolded proteins, RNA toxicity, or translational byproducts; dysfunctional autophagic machinery; and secondary As advances are made in understanding critical aspects of the underlying molecular pathophysiology, therapeutic strategies continue to evolve.
In this Special Issue, we aim to collect new findings addressing the etiology and diagnosis of motor neuron diseases, including the search for neuroprotective compounds and reliable biomarkers. Contributions related to motor neuron diseases are welcome, including original research articles and reviews.
Dr. Ilaria Martinelli
Dr. Elisabetta Zucchi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- motor neuron
- genetics
- oxidative stress
- misfolded protein aggregates
- biomarkers
- gene therapy
