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Brain Sciences
Special Issues
Research on Down Syndrome
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Research on Down Syndrome

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Developmental Neuroscience".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 4619

Special Issue Editor

Prof. Dr. Alberto Costa

E-Mail Website
Guest Editor
Department Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
Interests: down syndrome; neurophysiology; neuropsychology; preclinical research; clinical research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this Special Issue of Brain Sciences, we will be discussing the general topic of Research on Down Syndrome. We aim to highlight critical areas of basic and translational brain research that may one day lead to the discovery of pharmacological/genetic ways of addressing the developmental and intellectual disabilities, as well as neurodegenerative processes, associated with the trisomy of chromosome 21. We will welcome articles describing system-specific neuropsychological deficits and neurological and psychiatric disorders commonly found in persons with Down syndrome, new experimental data (collected from human beings and animal models) and reviews on the neurobiology and neuropharmacology of Down syndrome, and critical reviews on the design and conduct of clinical trials in this field. We hope we can count on your valuable contribution to make this a successful and impactful Special Issue for this journal.

Prof. Alberto Costa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • down syndrome
  • neuropsychology
  • neurobiology
  • genetics
  • neuropharmacology
  • clinical trials

Published Papers (1 paper)

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Review

21 pages, 301 KiB  
Review
On the Design of Broad-Based Neuropsychological Test Batteries to Assess the Cognitive Abilities of Individuals with Down Syndrome in the Context of Clinical Trials
by Ines A. Basten, Richard Boada, Hudson G. Taylor, Katherine Koenig, Veridiana L. Barrionuevo, Ana C. Brandão and Alberto C. S. Costa
Brain Sci. 2018, 8(12), 205; https://doi.org/10.3390/brainsci8120205 - 26 Nov 2018
Cited by 16 | Viewed by 4324
Abstract
Down syndrome (DS) is the most common genetically-defined cause of intellectual disability. Neurodevelopmental deficits displayed by individuals with DS are generally global, however, disproportionate deficits in cognitive processes that depend heavily on the hippocampus and prefrontal cortex are also well documented. Additionally, DS [...] Read more.
Down syndrome (DS) is the most common genetically-defined cause of intellectual disability. Neurodevelopmental deficits displayed by individuals with DS are generally global, however, disproportionate deficits in cognitive processes that depend heavily on the hippocampus and prefrontal cortex are also well documented. Additionally, DS is associated with relative strengths in visual processing and visuospatial short-term memory, and weaknesses in the verbal domain. Although reports of pharmacological rescuing of learning and memory deficits in mouse models of DS abound in the literature, proving the principle that cognitive ability of persons with DS can be boosted through pharmacological means is still an elusive goal. The design of customized batteries of neuropsychological efficacy outcome measures is essential for the successful implementation of clinical trials of potential cognitive enhancing strategies. Here, we review the neurocognitive phenotype of individuals with DS and major broad-based test batteries designed to quantify specific cognitive domains in these individuals, including the one used in a pilot trial of the drug memantine. The main goal is to illustrate the essential considerations in planning trials to enhance cognitive functions in individuals with DS, which should also have implications for the design of similar studies in individuals with other forms of intellectual disability. Full article
(This article belongs to the Special Issue Research on Down Syndrome)
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