Involvement of Blood-Brain Barrier Efficacy in the Healthy and Diseased Brain
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Systems Neuroscience".
Deadline for manuscript submissions: closed (19 August 2022) | Viewed by 2684
Special Issue Editors
Interests: blood–brain barrier in vitro model; ABC transporter; Drug transport studies; radiopharmaceutical; Glioblastomas; multidrug resistance
Interests: sleep disorders; autonomic nervous system function; brain MRI; cognitive disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, permeability abnormalities of the blood–brain barrier (BBB) have been a focus of several brain pathologies. The blood–brain barrier plays a central role in maintaining the specialized microenvironment of the central nervous system (CNS). Indeed, the BBB is a multicellular vascular structure composed of different cell types that act as a diffusion barrier to prevent the entry of most compounds from the blood to the brain, thus allowing the maintenance of cerebral neuronal homeostasis. Opening of the BBB linked to biostress and infiltration of serum components into the brain can lead to a multitude of processes resulting in progressive synaptic and neuronal dysfunction and detrimental neuroinflammatory changes. Such processes have been implicated in several diseases, such as Alzheimer's disease, obstructive sleep apnea (OSA), Parkinson's disease, and brain tumors. In this Special Issue of Brain Sciences, we will highlight recently acquired mechanistic knowledge on the development and maintenance of the functional and anatomical integrity of the BBB.
In this Special Issue, authors are invited to submit cutting-edge research and analysis, or review on a wide range of topics related to understanding the BBB, including preclinical in vitro and in vivo models, patient cohort studies, brain imaging, early diagnosis of neurodegenerative pathologies, and drug delivery. We will also discuss how BBB disruption can cause or contribute to neurological disease. Finally, we wish to present advances that may have a significant translational effect in knowledge, diagnosis and clinical follow-up.
Prof. Dr. Nathalie Perek
Prof. Dr. Frédéric Roche
Guest Editors
Manuscript Submission Information
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Keywords
- preclinical BBB models
- neuroinflammatory
- cognitive impairment
- imaging
- patient cohort
- Alzheimer’s disease
- Parkinson’s disease
- sleep disorders
- stress oxidative
- ABC transporter
- drug delivery
- pharmacoresistance
- hypoxia
- blood–brain tumor barrier
