Special Issue "Biomarkers in Neurotology"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotology and Neuro-ophthalmology".

Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 6481

Special Issue Editors

Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy
Interests: tinnitus; hair cells; neuroinflammation; choroid plexus; cochlear nuclei; electrophysiology; neuroimmune interactions; neuroanatomy; brain circuits
Tinnitus Center, European Hospital, 00149 Rome, Italy
Interests: tinnitus; hearing loss; hyperacusis; misophonia; clinical questionnaires; audiometry; benign paroxysmal positional vertigo; dizziness
Special Issues, Collections and Topics in MDPI journals
SSD Audiology and Phoniatrics, G. Rummo Hospital, 82100 Benevento, Italy
Interests: Meniere’s disease; sudden sensineural hearing loss (SSHL); neuroinflammation; inner ear fluids; glymphatic system; cerebrospinal fluid; neurodegenerative diseases
Eaton-Peabody Lab, Massachusetts Eye and Ear/Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA
Interests: EEG; rTMS; MRI; functional MRI; voxel-based morphometry; surface-based morphometry; higher-order diffusion-weighted imaging; resting-state fMRI analyses

Special Issue Information

Dear Colleagues,

Neurotology is a specialty closely related to vestibular and ear diseases (Meniere’s disease, vestibular neuronitis, vestibular schwannoma, facial nerve paralysis, otosclerosis, otitis, benign paroxysmal positional vertigo) and hearing disorders (tinnitus, hearing loss, deafness). The diagnosis and therapy of neurotological disorders are complex. The identification of biomarkers for neurotological disorders could help to better understand their underlying pathophysiological mechanisms, differential diagnosis, and response to therapy. In recent decades, clinical and biochemical markers, including imaging techniques and genetics, have emerged as promising tools for neurotology.

The current Special Issue of Brain Sciences aims to present the latest research on the role of clinical and biochemical markers for adult and pediatric neurotology.

Authors are invited to submit relevant original research and review papers.

Dr. Paola Perin
Dr. Alessandra Fioretti
Dr. Luigi Califano
Dr. Elouise Koops
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Hearing loss
  • Tinnitus
  • Meniere’s disease
  • Biomarkers
  • Benign paroxysmal positional vertigo
  • Vestibular schwannoma
  • Dizziness
  • Vestibular neuritis
  • Neuroinflammation
  • Imaging

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


6 pages, 648 KiB  
Hormones and Vestibular Disorders: The Quest for Biomarkers
Brain Sci. 2022, 12(5), 592; https://doi.org/10.3390/brainsci12050592 - 02 May 2022
Cited by 4 | Viewed by 5400
The vestibular system exerts control over various functions through neural pathways that are not yet fully mapped. Functional dysregulations or tissue lesions at different levels of the peripheral and the central vestibular networks can alter these different functions, causing a wide variety of [...] Read more.
The vestibular system exerts control over various functions through neural pathways that are not yet fully mapped. Functional dysregulations or tissue lesions at different levels of the peripheral and the central vestibular networks can alter these different functions, causing a wide variety of symptoms, ranging from posturo-locomotor alterations to psychiatric syndromes such as PPPD, including the deregulation of the main biological functions. These different symptoms differ by their expression kinetics (they each appear and regress with their own kinetics) by the targets affected (muscles, organs, and brain areas) and by the sensitivity specific to each individual. Vestibular pathologies thus cover a mosaic of distinct effects, and they involve various effectors—which constitute the many markers of their different types and stages. It is therefore crucial, to predict the onset of a vertigo syndrome, to follow its temporal course, or to monitor the impact of therapeutic approaches, and to have specific and reliable biomarkers. Hormonal variations are among the possible sources of biomarkers for neurotology. We know that specific hormonal profiles can promote the appearance of vestibular disorders. We also know that the expression of vertigo syndrome is accompanied by measurable hormonal variations. The link between endocrine deregulation and vestibular alterations therefore no longer needs to be proven. However, there are still few data on their precise correlations with the vertigo syndrome. This study was undertaken with the aim to deliver an extensive review of the hormonal alterations linked to vestibular disorders. A review of the literature covering the last two decades was carried out using the MEDLINE and COCHRANE databases in order to identify studies associating the terms vestibular system or vestibular pathologies and hormones. Bibliographic data provides several outcomes in terms of therapeutic innovation in the diagnosis and therapeutic follow-up of vestibular pathologies. Full article
(This article belongs to the Special Issue Biomarkers in Neurotology)
Show Figures

Figure 1

Back to TopTop