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Biosensors
Special Issues
Semiconductor-Based Biosensors
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Semiconductor-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 6765

Special Issue Editors

Prof. Dr. Alessandro Paccagnella

E-Mail Website
Guest Editor
Department of Information Engineering, University of Padua, via Gradenigo 6/b, 35131 Padua, Italy
Interests: sensors and microelectronic technologies; integrated sensors; reliability
Special Issues, Collections and Topics in MDPI journals
Dr. Stefano Bonaldo

E-Mail Website
Guest Editor
Department of Information Engineering, University of Padua, 35131 Padua, Italy
Interests: sensors; CMOS technologies; electrical modeling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to introduce a Special Issue on “Semiconductor-Based Biosensors” focused on the technology that has dramatically modified our society in recent decades. Semiconductor technology is the enabling technology that functions as the key of the IOT/IOE (r)evolution taking place now, where biosensing may gain a prominent role. Semiconductors have been involved in biosensing since the introduction of the first FET-based sensors, easy to measure and providing substantial currents for reliable quantitative label-free detection. Since then, ISFETs and other devices have been playing a pivotal role in the electrical detection of several analytes in a wide variety of biological and biomedical applications. Further, the microelectronic fabrication processes not only supply large quantities of well reproducible chips but permit also the integration of some front-end electronic blocks in the same chip, to locally perform the first signal elaboration steps boosting the sensing performance. Further, energy scavenging from suitable devices integrated in the chip may represent the solution for powering sensors in a system-on-a-chip approach. Following Moore’s law of miniaturization, in this century, the planar process has been complemented by 3D technologies where innovative sensor types have been designed and produced, based on solutions such as FinFETs and quantum dots. In parallel, new semiconductor materials, both inorganic and organic, are investigated to replace silicon as the platform for electrical and optical sensing.

Papers presenting advancements in these exciting research fields will be suitable for publication in the Special Issue.

Prof. Dr. Alessandro Paccagnella
Dr. Stefano Bonaldo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Traditional and innovative FET-based detection
  • Electrical sensing
  • Optical sensing
  • On-chip front-end electronics for biosensor signal processing
  • Biosensors on compound or organic semiconductors
  • Systems-on-chip
  • Lab-on-chip

Published Papers (2 papers)

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Research

12 pages, 1684 KiB  
Article
Detection of Influenza Virus Using a SOI-Nanoribbon Chip, Based on an N-Type Field-Effect Transistor
by Kristina A. Malsagova, Tatyana O. Pleshakova, Andrey F. Kozlov, Rafael A. Galiullin, Vladimir P. Popov, Fedor V. Tikhonenko, Alexander V. Glukhov, Vadim S. Ziborov, Ivan D. Shumov, Oleg F. Petrov, Vladimir M. Generalov, Anastasia A. Cheremiskina, Alexander G. Durumanov, Alexander P. Agafonov, Elena V. Gavrilova, Rinat A. Maksyutov, Alexander S. Safatov, Valentin G. Nikitaev, Alexander N. Pronichev, Vladimir A. Konev, Alexander I. Archakov and Yuri D. Ivanovadd Show full author list remove Hide full author list
Biosensors 2021, 11(4), 119; https://doi.org/10.3390/bios11040119 - 12 Apr 2021
Cited by 6 | Viewed by 2754
Abstract
The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the detector have been fabricated based on silicon-on-insulator nanoribbon structures (SOI nanoribbon chip), using a complementary metal-oxide-semiconductor (CMOS)-compatible technology—by means of gas-phase etching and standard optical [...] Read more.
The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the detector have been fabricated based on silicon-on-insulator nanoribbon structures (SOI nanoribbon chip), using a complementary metal-oxide-semiconductor (CMOS)-compatible technology—by means of gas-phase etching and standard optical photolithography. The surface of the SOI nanoribbon chip contains a matrix of 10 nanoribbon (NR) sensor elements. SOI nanoribbon chips of n-type conductance have been used for this study. For biospecific detection of target particles, antibodies against influenza virus have been covalently immobilized onto NRs. Influenza A virus detection was performed by real-time registration of the source-drain current through the NRs. The detection of the target viral particles was carried out in buffer solutions at the target particles concentration within the range from 107 to 103 viral particles per milliliter (VP/mL). The lowest detectable concentration of the target viral particles was 6 × 10−16 M (corresponding to 104 VP/mL). The use of solutions containing ~109 to 1010 VP/mL resulted in saturation of the sensor surface with the target virions. In the saturation mode, detection was impossible. Full article
(This article belongs to the Special Issue Semiconductor-Based Biosensors)
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16 pages, 5087 KiB  
Article
Silicon Nanowire Field-Effect Transistor as Biosensing Platforms for Post-Translational Modification
by Ping-Chia Su, Bo-Han Chen, Yi-Chan Lee and Yuh-Shyong Yang
Biosensors 2020, 10(12), 213; https://doi.org/10.3390/bios10120213 - 21 Dec 2020
Cited by 10 | Viewed by 2966
Abstract
Protein tyrosine sulfation (PTS), a vital post-translational modification, facilitates protein–protein interactions and regulates many physiological and pathological responses. Monitoring PTS has been difficult owing to the instability of sulfated proteins and the lack of a suitable method for detecting the protein sulfate ester. [...] Read more.
Protein tyrosine sulfation (PTS), a vital post-translational modification, facilitates protein–protein interactions and regulates many physiological and pathological responses. Monitoring PTS has been difficult owing to the instability of sulfated proteins and the lack of a suitable method for detecting the protein sulfate ester. In this study, we combined an in situ PTS system with a high-sensitivity polysilicon nanowire field-effect transistor (pSNWFET)-based sensor to directly monitor PTS formation. A peptide containing the tyrosine sulfation site of P-selectin glycoprotein ligand (PSGL)-1 was immobilized onto the surface of the pSNWFET by using 3-aminopropyltriethoxysilane and glutaraldehyde as linker molecules. A coupled enzyme sulfation system consisting of tyrosylprotein sulfotransferase and phenol sulfotransferase was used to catalyze PTS of the immobilized PSGL-1 peptide. Enzyme-catalyzed sulfation of the immobilized peptide was readily observed through the shift of the drain current–gate voltage curves of the pSNWFET before and after PTS. We expect that this approach can be developed as a next generation biochip for biomedical research and industries. Full article
(This article belongs to the Special Issue Semiconductor-Based Biosensors)
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