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Biosensors
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Advances in Quantum Dots Biosensing
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Advances in Quantum Dots Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 19429

Special Issue Editor

Prof. Dr. Chunyang Zhang

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China
Interests: single-molecule detection; single-molecule imaging; biosensors; nanosensors; nucleic acids; enzymes; quantum dots
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The progress in biological research and clinical practice is heavily dependent on sensitive and selective biosensing of interesting biomolecules. Due to their unique and superior optical, electronic properties such as high brightness, good photostability, broad absorption spectrum, narrow and size-tunable emission spectrum, large Stokes shift, versatile surface modification, and distinctive photoelectrochemical activity, quantum dots have emerged as powerful building blocks for the development of efficient biosensors with high sensitivity, good selectively, rapidity, and simplicity.

This Special Issue on “Advances in Quantum Dot Biosensing” aims to present the most advanced biosensing technologies using quantum dots as the sensing elements and to demonstrate their applications in the quantitative detection of diverse biomolecules such as DNAs, RNAs, proteins, enzymes, and live cells.

Prof. Dr. Chunyang Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quantum dot
  • biosensing

Published Papers (6 papers)

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Research

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14 pages, 4346 KiB  
Article
Ultrasensitive Fluorescence Lateral Flow Assay for Simultaneous Detection of Pseudomonas aeruginosa and Salmonella typhimurium via Wheat Germ Agglutinin-Functionalized Magnetic Quantum Dot Nanoprobe
by Zhijie Tu, Xingsheng Yang, Hao Dong, Qing Yu, Shuai Zheng, Xiaodan Cheng, Chongwen Wang, Zhen Rong and Shengqi Wang
Biosensors 2022, 12(11), 942; https://doi.org/10.3390/bios12110942 - 31 Oct 2022
Cited by 6 | Viewed by 2101
Abstract
Point-of-care testing methods for the rapid and sensitive screening of pathogenic bacteria are urgently needed because of the high number of outbreaks of microbial infections and foodborne diseases. In this study, we developed a highly sensitive and multiplex lateral flow assay (LFA) for [...] Read more.
Point-of-care testing methods for the rapid and sensitive screening of pathogenic bacteria are urgently needed because of the high number of outbreaks of microbial infections and foodborne diseases. In this study, we developed a highly sensitive and multiplex lateral flow assay (LFA) for the simultaneous detection of Pseudomonas aeruginosa and Salmonella typhimurium in complex samples by using wheat germ agglutinin (WGA)-modified magnetic quantum dots (Mag@QDs) as a universal detection nanoprobe. The Mag@QDs-WGA tag with a 200 nm Fe3O4 core and multiple QD-formed shell was introduced into the LFA biosensor for the universal capture of the two target bacteria and provided the dual amplification effect of fluorescence enhancement and magnetic enrichment for ultra-sensitivity detection. Meanwhile, two antibacterial antibodies were separately sprayed onto the two test lines of the LFA strip to ensure the specific identification of P. aeruginosa and S. typhimurium through one test. The proposed LFA exhibited excellent analytical performance, including high capture rate (>80%) to the target pathogens, low detection limit (<30 cells/mL), short testing time (<35 min), and good reproducibility (relative standard deviation < 10.4%). Given these merits, the Mag@QDs-WGA-based LFA has a great potential for the on-site and real-time diagnosis of bacterial samples. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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11 pages, 17282 KiB  
Article
Dual-Color Fluorescent Hydrogel Microspheres Combined with Smartphones for Visual Detection of Lactate
by Sisi Yang, Ziwen Tang, Yilong Tian, Xinghu Ji, Fubing Wang, Conghua Xie and Zhike He
Biosensors 2022, 12(10), 802; https://doi.org/10.3390/bios12100802 - 28 Sep 2022
Cited by 2 | Viewed by 1746
Abstract
Since it is difficult for human eyes to distinguish between two identical colors with only <15% variation in brightness, mono-color fluorescent hydrogel microspheres have some limitations in the detection of lactate. Herein, we prepared novel dual-color fluorescent hydrogel microspheres, which can achieve hue [...] Read more.
Since it is difficult for human eyes to distinguish between two identical colors with only <15% variation in brightness, mono-color fluorescent hydrogel microspheres have some limitations in the detection of lactate. Herein, we prepared novel dual-color fluorescent hydrogel microspheres, which can achieve hue transformation. Microspheres were prepared by introducing a fluorescent nanoparticle as the reference signal while CdTe QDs were used as the response signal. We used smartphones with image processing software to collect and analyze data. In this way, the signal of lactate was converted to RGB (red, green, and blue) values, which can be quantitatively read. Within 10 to 1500 μM, the R/G values of the microspheres had a linear relationship with the logarithm of the lactate concentration. Moreover, color cards for lactate detection were prepared, from which the color change and concentration of lactate could be easily read by the naked eye. It is worth mentioning that this method was successfully applied to screen patients with hyperlactatemia. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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Review

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16 pages, 2443 KiB  
Review
Recent Advances in Silicon Quantum Dot-Based Fluorescent Biosensors
by Yanan Zhang, Ning Cai and Vincent Chan
Biosensors 2023, 13(3), 311; https://doi.org/10.3390/bios13030311 - 23 Feb 2023
Cited by 10 | Viewed by 2618
Abstract
With the development of nanotechnology, fluorescent silicon nanomaterials have been synthesized and applied in various areas. Among them, silicon quantum dots (SiQDs) are a new class of zero-dimensional nanomaterials with outstanding optical properties, benign biocompatibility, and ultra-small size. In recent years, SiQDs have [...] Read more.
With the development of nanotechnology, fluorescent silicon nanomaterials have been synthesized and applied in various areas. Among them, silicon quantum dots (SiQDs) are a new class of zero-dimensional nanomaterials with outstanding optical properties, benign biocompatibility, and ultra-small size. In recent years, SiQDs have been gradually utilized for constructing high-performance fluorescent sensors for chemical or biological analytes. Herein, we focus on reviewing recent advances in SiQD-based fluorescent biosensors from a broad perspective and discussing possible future trends. First, the representative progress for synthesizing water-soluble SiQDs in the past decade is systematically summarized. Then, the latest achievement of the design and fabrication of SiQD-based fluorescent biosensors is introduced, with a particular focus on analyte-induced photoluminescence (fluorescence) changes, hybrids of SiQDs with other materials or molecules, and biological ligand-modification methods. Finally, the current challenges and prospects of this field are highlighted. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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18 pages, 5159 KiB  
Review
Recent Progress of Perovskite Nanocrystals in Chem/Bio Sensing
by Dailu Jia, Meng Xu, Shuang Mu, Wei Ren and Chenghui Liu
Biosensors 2022, 12(9), 754; https://doi.org/10.3390/bios12090754 - 14 Sep 2022
Cited by 6 | Viewed by 2728
Abstract
Perovskite nanocrystals (PNCs) are endowed with extraordinary photophysical properties such as wide absorption spectra, high quantum yield, and narrow emission bands. However, the inherent shortcomings, especially the instability in polar solvents and water incompatibility, have hindered their application as probes in chem/bio sensing. [...] Read more.
Perovskite nanocrystals (PNCs) are endowed with extraordinary photophysical properties such as wide absorption spectra, high quantum yield, and narrow emission bands. However, the inherent shortcomings, especially the instability in polar solvents and water incompatibility, have hindered their application as probes in chem/bio sensing. In this review, we give a fundamental understanding of the challenges when using PNCs for chem/bio sensing and summarize recent progress in this area, including the application of PNCs in various sensors and the corresponding strategies to maintain their structural integrity. Finally, we provide perspectives to promote the future development of PNCs for chem/bio sensing applications. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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21 pages, 3362 KiB  
Review
Two-Dimensional Quantum Dot-Based Electrochemical Biosensors
by Jian Zhang, Xiaoyue Zhang and Sai Bi
Biosensors 2022, 12(4), 254; https://doi.org/10.3390/bios12040254 - 17 Apr 2022
Cited by 12 | Viewed by 3383
Abstract
Two-dimensional quantum dots (2D-QDs) derived from two-dimensional sheets have received increasing interest owing to their unique properties, such as large specific surface areas, abundant active sites, good aqueous dispersibility, excellent electrical property, easy functionalization, and so on. A variety of 2D-QDs have been [...] Read more.
Two-dimensional quantum dots (2D-QDs) derived from two-dimensional sheets have received increasing interest owing to their unique properties, such as large specific surface areas, abundant active sites, good aqueous dispersibility, excellent electrical property, easy functionalization, and so on. A variety of 2D-QDs have been developed based on different materials including graphene, black phosphorus, nitrides, transition metal dichalcogenides, transition metal oxides, and MXenes. These 2D-QDs share some common features due to the quantum confinement effects and they also possess unique properties owing to their structural differences. In this review, we discuss the categories, properties, and synthetic routes of these 2D-QDs and emphasize their applications in electrochemical biosensors. We deeply hope that this review not only stimulates more interest in 2D-QDs, but also promotes further development and applications of 2D-QDs in various research fields. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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Other

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11 pages, 1789 KiB  
Perspective
Graphene Quantum Dots-Based Electrochemical Biosensing Platform for Early Detection of Acute Myocardial Infarction
by Tanveer A. Tabish, Hasan Hayat, Aumber Abbas and Roger J. Narayan
Biosensors 2022, 12(2), 77; https://doi.org/10.3390/bios12020077 - 28 Jan 2022
Cited by 28 | Viewed by 5852
Abstract
Heart failure resulting from acute myocardial infarction (AMI) is an important global health problem. Treatments of heart failure and AMI have improved significantly over the past two decades; however, the available diagnostic tests only give limited insights into these heterogeneous conditions at a [...] Read more.
Heart failure resulting from acute myocardial infarction (AMI) is an important global health problem. Treatments of heart failure and AMI have improved significantly over the past two decades; however, the available diagnostic tests only give limited insights into these heterogeneous conditions at a reversible stage and are not precise enough to evaluate the status of the tissue at high risk. Innovative diagnostic tools for more accurate, more reliable, and early diagnosis of AMI are urgently needed. A promising solution is the timely identification of prognostic biomarkers, which is crucial for patients with AMI, as myocardial dysfunction and infarction lead to more severe and irreversible changes in the cardiovascular system over time. The currently available biomarkers for AMI detection include cardiac troponin I (cTnI), cardiac troponin T (cTnT), myoglobin, lactate dehydrogenase, C-reactive protein, and creatine kinase and myoglobin. Most recently, electrochemical biosensing technologies coupled with graphene quantum dots (GQDs) have emerged as a promising platform for the identification of troponin and myoglobin. The results suggest that GQDs-integrated electrochemical biosensors can provide useful prognostic information about AMI at an early, reversible, and potentially curable stage. GQDs offer several advantages over other nanomaterials that are used for the electrochemical detection of AMI such as strong interactions between cTnI and GQDs, low biomarker consumption, and reusability of the electrode; graphene-modified electrodes demonstrate excellent electrochemical responses due to the conductive nature of graphene and other features of GQDs (e.g., high specific surface area, π–π interactions with the analyte, facile electron-transfer mechanisms, size-dependent optical features, interplay between bandgap and photoluminescence, electrochemical luminescence emission capability, biocompatibility, and ease of functionalization). Other advantages include the presence of functional groups such as hydroxyl, carboxyl, carbonyl, and epoxide groups, which enhance the solubility and dispersibility of GQDs in a wide variety of solvents and biological media. In this perspective article, we consider the emerging knowledge regarding the early detection of AMI using GQDs-based electrochemical sensors and address the potential role of this sensing technology which might lead to more efficient care of patients with AMI. Full article
(This article belongs to the Special Issue Advances in Quantum Dots Biosensing)
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