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Biosensors
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Recent Advances in Wearable Biosensors for Human Health Monitoring
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Recent Advances in Wearable Biosensors for Human Health Monitoring

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Wearable Biosensors".

Deadline for manuscript submissions: 1 September 2024 | Viewed by 5021

Special Issue Editor

Dr. Xiaojun Xian

E-Mail Website
Guest Editor
Department of Electrical Engineering and Computer Scicence, South Dakota State University, Brookings, SD 57007, USA
Interests: biosensors; chemical sensors; wearable healthcare devices; medical device design; mobile health; data science; advanced sensing materials; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Wearable biosensors are surging, as evidenced by the escalating interest from both academia and the healthcare industry. Due to their capability for the noninvasive, real-time, and continuous monitoring of various health information of the human body, wearable biosensors have shown unique advantages in remote patient tracking, early diagnosis, and personalized medicine. Substantial progress has been made in the development of wearable biosensing technologies for detecting biomarkers in sweat, tears, saliva, and interstitial fluid. Biosensors have been integrated with various wearable platforms, such as contact lenses, wristbands, patches, tattoos, and retainers, for the detection of different biomarkers (e.g., glucose, lactate, electrolytes, pH, salivary uric acid). The potential of wearable biosensors can be further boosted by additive manufacturing (3D printing), artificial intelligence, internet of things, and big data technologies.

In this Special Issue, we would like to invite you to contribute research articles, reviews, or perspectives related to “Wearable Biosensors for Human Health Monitoring”. The welcomed topics include, but are not limited to, smart biosensing materials, novel wearable biosensing technologies, power management and energy harvesting, data transmission, algorithm development, wearable device integration, and performance validation.

Dr. Xiaojun Xian
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wearable biosensors
  • wearable biomedical devices
  • noninvasive biosensors
  • wireless biosensors
  • biomarkers
  • biofluids
  • interstitial fluid
  • saliva
  • tears
  • sweat
  • breath
  • electrochemical sensing
  • colorimetric sensing
  • optical sensing
  • continuous monitoring
  • healthcare

Published Papers (3 papers)

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Research

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11 pages, 8063 KiB  
Article
Fundamental Study of a Wristwatch Sweat Lactic Acid Monitor
by Sakae Konno and Hiroyuki Kudo
Biosensors 2024, 14(4), 187; https://doi.org/10.3390/bios14040187 - 10 Apr 2024
Viewed by 460
Abstract
A lactic acid (LA) monitoring system aimed at sweat monitoring was fabricated and tested. The sweat LA monitoring system uses a continuous flow of phosphate buffer saline, instead of chambers or cells, for collecting and storing sweat fluid excreted at the skin surface. [...] Read more.
A lactic acid (LA) monitoring system aimed at sweat monitoring was fabricated and tested. The sweat LA monitoring system uses a continuous flow of phosphate buffer saline, instead of chambers or cells, for collecting and storing sweat fluid excreted at the skin surface. To facilitate the use of the sweat LA monitoring system by subjects when exercising, the fluid control system, including the sweat sampling device, was designed to be unaffected by body movements or muscle deformation. An advantage of our system is that the skin surface condition is constantly refreshed by continuous flow. A real sample test was carried out during stationary bike exercise, which showed that LA secretion increased by approximately 10 μg/cm2/min compared to the baseline levels before exercise. The LA levels recovered to baseline levels after exercise due to the effect of continuous flow. This indicates that the wristwatch sweat LA monitor has the potential to enable a detailed understanding of the LA distribution at the skin surface. Full article
(This article belongs to the Special Issue Recent Advances in Wearable Biosensors for Human Health Monitoring)
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17 pages, 2633 KiB  
Article
Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors
by Felipe Contreras-Briceño, Maximiliano Espinosa-Ramírez, Augusta Rivera-Greene, Camila Guerra-Venegas, Antonia Lungenstrass-Poulsen, Victoria Villagra-Reyes, Raúl Caulier-Cisterna, Oscar F. Araneda and Ginés Viscor
Biosensors 2023, 13(11), 985; https://doi.org/10.3390/bios13110985 - 13 Nov 2023
Viewed by 1613
Abstract
Exercise increases the cost of breathing (COB) due to increased lung ventilation (V˙E), inducing respiratory muscles deoxygenation (∇SmO2), while the increase in workload implies ∇SmO2 in locomotor muscles. This phenomenon has been proposed as [...] Read more.
Exercise increases the cost of breathing (COB) due to increased lung ventilation (V˙E), inducing respiratory muscles deoxygenation (∇SmO2), while the increase in workload implies ∇SmO2 in locomotor muscles. This phenomenon has been proposed as a leading cause of exercise intolerance, especially in clinical contexts. The use of high-flow nasal cannula (HFNC) during exercise routines in rehabilitation programs has gained significant interest because it is proposed as a therapeutic intervention for reducing symptoms associated with exercise intolerance, such as fatigue and dyspnea, assuming that HFNC could reduce exercise-induced ∇SmO2. SmO2 can be detected using optical wearable devices provided by near-infrared spectroscopy (NIRS) technology, which measures the changes in the amount of oxygen bound to chromophores (e.g., hemoglobin, myoglobin, cytochrome oxidase) at the target tissue level. We tested in a study with a cross-over design whether the muscular desaturation of m.vastus lateralis and m.intercostales during a high-intensity constant-load exercise can be reduced when it was supported with HFNC in non-physically active adults. Eighteen participants (nine women; age: 22 ± 2 years, weight: 65.1 ± 11.2 kg, height: 173.0 ± 5.8 cm, BMI: 21.6 ± 2.8 kg·m−2) were evaluated in a cycle ergometer (15 min, 70% maximum watts achieved in ergospirometry (V˙O2-peak)) breathing spontaneously (control, CTRL) or with HFNC support (HFNC; 50 L·min−1, fiO2: 21%, 30 °C), separated by seven days in randomized order. Two-way ANOVA tests analyzed the ∇SmO2 (m.intercostales and m.vastus lateralis), and changes in V˙E and ∇SmO2·V˙E−1. Dyspnea, leg fatigue, and effort level (RPE) were compared between trials by the Wilcoxon matched-paired signed rank test. We found that the interaction of factors (trial × exercise-time) was significant in ∇SmO2-m.intercostales, V˙E, and (∇SmO2-m.intercostales)/V˙E (p < 0.05, all) but not in ∇SmO2-m.vastus lateralis. ∇SmO2-m.intercostales was more pronounced in CTRL during exercise since 5′ (p < 0.05). Hyperventilation was higher in CTRL since 10′ (p < 0.05). The ∇SmO2·V˙E−1 decreased during exercise, being lowest in CTRL since 5′. Lower dyspnea was reported in HFNC, with no differences in leg fatigue and RPE. We concluded that wearable optical biosensors documented the beneficial effect of HFNC in COB due to lower respiratory ∇SmO2 induced by exercise. We suggest incorporating NIRS devices in rehabilitation programs to monitor physiological changes that can support the clinical impact of the therapeutic intervention implemented. Full article
(This article belongs to the Special Issue Recent Advances in Wearable Biosensors for Human Health Monitoring)
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Review

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22 pages, 1736 KiB  
Review
New Advances in Antenna Design toward Wearable Devices Based on Nanomaterials
by Chunge Wang, Ning Zhang, Chen Liu, Bangbang Ma, Keke Zhang, Rongzhi Li, Qianqian Wang and Sheng Zhang
Biosensors 2024, 14(1), 35; https://doi.org/10.3390/bios14010035 - 10 Jan 2024
Cited by 1 | Viewed by 2108
Abstract
Wearable antennas have recently garnered significant attention due to their attractive properties and potential for creating lightweight, compact, low-cost, and multifunctional wireless communication systems. With the breakthrough progress in nanomaterial research, the use of lightweight materials has paved the way for the widespread [...] Read more.
Wearable antennas have recently garnered significant attention due to their attractive properties and potential for creating lightweight, compact, low-cost, and multifunctional wireless communication systems. With the breakthrough progress in nanomaterial research, the use of lightweight materials has paved the way for the widespread application of wearable antennas. Compared with traditional metallic materials like copper, aluminum, and nickel, nanoscale entities including zero-dimensional (0-D) nanoparticles, one-dimensional (1-D) nanofibers or nanotubes, and two-dimensional (2-D) nanosheets exhibit superior physical, electrochemical, and performance characteristics. These properties significantly enhance the potential for constructing durable electronic composites. Furthermore, the antenna exhibits compact size and high deformation stability, accompanied by greater portability and wear resistance, owing to the high surface-to-volume ratio and flexibility of nanomaterials. This paper systematically discusses the latest advancements in wearable antennas based on 0-D, 1-D, and 2-D nanomaterials, providing a comprehensive overview of their development and future prospects in the field. Full article
(This article belongs to the Special Issue Recent Advances in Wearable Biosensors for Human Health Monitoring)
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