Special Issue "Biosensors Based on Transistors"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2191

Special Issue Editors

Department of Electronic Engineering, Jeonbuk National University, Jeonju, Republic of Korea
Interests: semiconductor devices; nanodevices; biosensors; optical sensors
Indian Institute of Technology Guwahati, Guwahati, India
Interests: chem, bio and radiation sensors; nanomaterials such as carbon nanotubes; graphene and inorganic nanowires and their application development in sensors, electronics, optoelectronics and energy storage

Special Issue Information

Dear Colleagues,

The COVID-19 pandemic, which broke out worldwide in early 2020, not only severely damaged the global economy, but also disrupted everyday life. Fast diagnostic technology with cost-effective features is crucial to prevent these enormous damages. However, the common diagnostics methods, such as the enzyme-linked immunosorbent assay (ELISA) and polymerase chain reactions (PCRs), are not suitable to effectively contain the spread of infectious diseases, because they require sample delivery to the laboratory facilities, well-trained operators and expensive laboratory equipment. Field-effect transistor (FET)-based biosensors have received considerable attention as one of the powerful diagnostic platforms due to label-free and real-time detection, high sensitivity, high selectivity and compact size. FET-based biosensors have been widely utilized from basic science to clinical tests. Various nanostructures over the past decade have produced significant advances in FET-based biosensor technology, resulting in highly sensitive sensor devices capable of successfully detecting down to a concentration of a few pg/mL. However, the sensitivity still needs to be greatly enhanced for the detection of significant analytes such as antigens and viruses, which are deadly or pathogenic even in ultra-low quantities

This Special Issue aims to collect outstanding research articles on recent advances in FET-based biosensors. The scope of this Special Issue covers, but is not limited to, new detection schemes, novel structure and materials, and methods for improving sensing performance such as sensitivity and selectivity, and novel applications. If the research is related to biosensing, there are no major limitations. Both original research articles and review articles describing the current state of the art in FET-based biosensors are invited.

Dr. Kihyun Kim
Dr. Meyya Meyyappan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • field-effect transistors
  • BioFETs
  • electrolyte-gated transistor
  • flexible biosensor
  • biomarkers
  • surface functionalization
  • diagnostics
  • point-of-care
  • clinical applications

Published Papers (2 papers)

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Research

14 pages, 4110 KiB  
Article
Ultrasensitive Silicon Nanowire Biosensor with Modulated Threshold Voltages and Ultra-Small Diameter for Early Kidney Failure Biomarker Cystatin C
Biosensors 2023, 13(6), 645; https://doi.org/10.3390/bios13060645 - 13 Jun 2023
Viewed by 833
Abstract
Acute kidney injury (AKI) is a frequently occurring severe disease with high mortality. Cystatin C (Cys-C), as a biomarker of early kidney failure, can be used to detect and prevent acute renal injury. In this paper, a biosensor based on a silicon nanowire [...] Read more.
Acute kidney injury (AKI) is a frequently occurring severe disease with high mortality. Cystatin C (Cys-C), as a biomarker of early kidney failure, can be used to detect and prevent acute renal injury. In this paper, a biosensor based on a silicon nanowire field-effect transistor (SiNW FET) was studied for the quantitative detection of Cys-C. Based on the spacer image transfer (SIT) processes and channel doping optimization for higher sensitivity, a wafer-scale, highly controllable SiNW FET was designed and fabricated with a 13.5 nm SiNW. In order to improve the specificity, Cys-C antibodies were modified on the oxide layer of the SiNW surface by oxygen plasma treatment and silanization. Furthermore, a polydimethylsiloxane (PDMS) microchannel was involved in improving the effectiveness and stability of detection. The experimental results show that the SiNW FET sensors realize the lower limit of detection (LOD) of 0.25 ag/mL and have a good linear correlation in the range of Cys-C concentration from 1 ag/mL to 10 pg/mL, exhibiting its great potential in the future real-time application. Full article
(This article belongs to the Special Issue Biosensors Based on Transistors)
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9 pages, 3482 KiB  
Communication
Highly Sensitive Detection of Urea Using Si Electrolyte-Gated Transistor with Low Power Consumption
Biosensors 2023, 13(5), 565; https://doi.org/10.3390/bios13050565 - 22 May 2023
Viewed by 800
Abstract
We experimentally demonstrate Si-based electrolyte-gated transistors (EGTs) for detecting urea. The top-down-fabricated device exhibited excellent intrinsic characteristics, including a low subthreshold swing (SS) (~80 mV/dec) and a high on/off current ratio (~107). The sensitivity, which varied depending on the [...] Read more.
We experimentally demonstrate Si-based electrolyte-gated transistors (EGTs) for detecting urea. The top-down-fabricated device exhibited excellent intrinsic characteristics, including a low subthreshold swing (SS) (~80 mV/dec) and a high on/off current ratio (~107). The sensitivity, which varied depending on the operation regime, was analyzed with the urea concentrations ranging from 0.1 to 316 mM. The current-related response could be enhanced by reducing the SS of the devices, whereas the voltage-related response remained relatively constant. The urea sensitivity in the subthreshold regime was as high as 1.9 dec/pUrea, four times higher than the reported value. The extracted power consumption of 0.3 nW was extremely low compared to other FET-type sensors. Full article
(This article belongs to the Special Issue Biosensors Based on Transistors)
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