Special Issue "Electrochemical (Bio-) Sensors in Biological Applications—2nd Edition"

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 25 March 2024 | Viewed by 1868

Special Issue Editors

Department of Physical Chemistry, Plovdiv University, 4000 Plovdiv, Bulgaria
Interests: sensor design; sensor architecture; immobilization; bioreceptor; biomimics; advanced materials; disease diagnosis; pharmaceutical analysis; forensic sciences; pathogens
Special Issues, Collections and Topics in MDPI journals
Department of Analytical Chemistry, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, 4 Pasteur Street, 400349 Cluj-Napoca, Romania
Interests: electrochemical and optical sensors; graphene; nanomaterials based electrodes; bioanalysis
Special Issues, Collections and Topics in MDPI journals
Department of Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden
Interests: bioelectrochemistry; bioelectronics; biomedical technology

Special Issue Information

Dear Colleagues,

After the successful accomplishment of the first Volume of the Special Issue entitled “Electrochemical (Bio-) Sensors in Biological Applications”, the Journal’s Editorial Board, in collaboration with the Guest Editors Dr. Nina Dimcheva (assoc. prof.), Prof. Dr. Cecilia Cristea and Prof. Dr. Sergey Shleev, is launching Volume II under the same title.  This Special Issue is dedicated to the electrochemical sensors and biosensors applicable in diseases diagnosis; clinical, pharmaceutical, agricultural, food and forensic analyses; and any other area of biological interest.

In addition to those already announced in the Volume I, the following topics may be addressed:

  • Sensor design: the application of nanomaterials and bio-nanomaterials, hybrid materials, composites, biomimics or bio-inspired materials in sensor architecture, and the immobilization of bio receptors (proteins, nucleic acids, tissues, microorganisms, etc.) as a tool for its stabilization.
  • Area of application: sensors/biosensors for disease diagnosis; clinical analysis, drug discovery and pharmacy; forensic science and food analyses; and any of other field of biological
  • Sensor’s analytical performance: the selectivity of analysis in complex matrices, low detection limits, etc.

Volume II will focus also on cutting-edge sensing technologies, including the following:

- electronic noses and tongues;

- wearables and point-of-care (POC) devices;

- ingestible sensors for disease monitoring;

- molecularly imprinted polymers (MIPs) and nano-MIP-based sensors.

Both critical reviews and original research articles that address analytical aspects (selectivity, validation, etc.), the design of sensing devices and/or platforms (bioreceptor immobilization, use of bio-mimics, bio-inspired catalysts) or sensing principles will be considered for publication.

Dr. Nina Dimcheva
Prof. Dr. Cecilia Cristea
Prof. Dr. Sergey Shleev
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensor design
  • sensor architecture
  • immobilization
  • bio-receptor
  • bio-mimics
  • advanced materials
  • disease diagnosis
  • pharmaceutical analysis
  • forensic sciences
  • pathogens

Published Papers (2 papers)

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Research

13 pages, 2647 KiB  
Article
Functionalized GD2 Electrochemical Immunosensor to Diagnose Minimum Residual Disease of Bone Marrow in Neuroblastoma Effectively
Biosensors 2023, 13(10), 920; https://doi.org/10.3390/bios13100920 - 10 Oct 2023
Viewed by 749
Abstract
Neuroblastoma (NB) is known as the “king of childhood tumors” due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics. International Neuroblastoma Risk Grading Group (INRG) has recommended GD2, a disialoganglioside expressed on neuroectodermal tumor cells, as the target for detecting minimal residual disease [...] Read more.
Neuroblastoma (NB) is known as the “king of childhood tumors” due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics. International Neuroblastoma Risk Grading Group (INRG) has recommended GD2, a disialoganglioside expressed on neuroectodermal tumor cells, as the target for detecting minimal residual disease in bone marrow metastases of high-risk neuroblastoma in children. Therefore, accurately identifying GD2-positive cells is crucial for diagnosing children with high-risk NB. Here, we designed a graphene/AuNP/GD2 Ab-functionalized electrochemical biosensor for GD2 detection. A three-electrode system was processed using a screen-printed technique with a working electrode of indium tin oxide, a counter electrode of carbon, and a reference electrode of silver/silver chloride. Graphene/AuNPs were modified on the indium tin oxide electrode using chronoamperometric scans, and then, the GD2 antibody was modified on the biosensor by electrostatic adsorption to achieve sensitive and specific detection of GD2-positive cells in bone marrow fluid. The results showed that a graphene/AuNP/GD2 Ab-functionalized electrochemical biosensor achieved GD2-positive cell detection in the range of 102 cells/mL~105 cells/mL by differential pulse voltammetry. Bone marrow fluid samples from 12 children with high-risk NB were retained for testing on our biosensor and showed 100% compliance with the clinical application of the gold-standard immunocytochemical staining technique for detecting GD2-positive cells qualitatively. The GD2-based electrochemical assay can accurately detect children with high-risk NB, providing a rapidly quantitative basis for clinical diagnosis and treatment. Full article
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13 pages, 5441 KiB  
Article
A Floating Capsule Electrochemical System for In Situ and Multichannel Ion-Selective Sensing
Biosensors 2023, 13(10), 914; https://doi.org/10.3390/bios13100914 - 05 Oct 2023
Viewed by 884
Abstract
Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, [...] Read more.
Free-floating electrochemical sensors are promising for in situ bioprocess monitoring with the advantages of movability, a lowered risk of contamination, and a simplified structure of the bioreactor. Although floating sensors were developed for the measurement of physical and chemical indicators such as temperature, velocity of flow, pH, and dissolved oxygen, it is the lack of available electrochemical sensors for the determination of the inorganic ions in bioreactors that has a significant influence on cell culture. In this study, a capsule-shaped electrochemical system (iCapsuleEC) is developed to monitor ions including K+, NH4+, Na+, Ca2+, and Mg2+ based on solid-contact ion-selective electrodes (SC-ISEs). It consists of a disposable electrochemical sensor and signal-processing device with features including multichannel measurement, self-calibration, and wireless data transmission. The capacities of the iCapsuleEC were demonstrated not only for in situ measurement of ion concentrations but also for the optimization of the sensing electrodes. We also explored the possibility of the system for use in detection in simulated cell culture media. Full article
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