Optical Biosensors for Label-Free Detection

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1293

Special Issue Editors


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Guest Editor
1. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022 Valencia, Spain
2. Departamento de Química, Universitat Politècnica de València, 46022 Valencia, Spain
Interests: optical biosensors; label-free; point-of-care; diffraction; biolayers; gratings; nanopatterning; immunosensors; signal processing; nanostructures; transduction; photonics

E-Mail Website
Guest Editor
1. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46022 Valencia, Spain
2. Departamento de Química, Universitat Politècnica de València, 46022 Valencia, Spain
Interests: immunochemical methods; surface chemistry; nanomaterials for bioanalysis; photonic biosensing; screening systems; bioreagents development
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Special Issue Information

Dear Colleagues,

We are pleased to invite contributions to this Special Issue on optical label-free biosensing. This innovative field lies at the intersection of chemistry, optics, biology, nanoscience, engineering, and materials science, and offers new and unique solutions to society's analytical needs.

The scope of this Special Issue is broad, ranging from fundamental studies at the proof-of-concept level to novel applications of label-free technologies in relevant scenarios. Our goal is to bring together the latest advancements in consolidated transduction systems (SPR, interferometry, SERS, fiber-based sensors, etc.) while also encouraging contributions on emerging materials and biosensing principles.

We welcome full-length research papers, short communications featuring groundbreaking preliminary results or significant findings, as well as review papers that comprehensively cover relevant aspects of optical label-free biosensing.

We look forward to your participation in this Special Issue.

Dr. Miquel Avella-Oliver
Prof. Dr. Ángel Maquieira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • label-free
  • biosensor
  • plasmonics
  • photonics
  • nanostructure
  • transduction
  • point-of-care
  • lab-on-a-chip
  • wearable
  • SPR
  • SERS
  • waveguiding
  • interferometry
  • immunosensor
  • DNA biosensors

Published Papers (1 paper)

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Research

15 pages, 5424 KiB  
Article
Biosensing by Polymer-Coated Etched Long-Period Fiber Gratings Working near Mode Transition and Turn-around Point
by Tanoy Kumar Dey, Cosimo Trono, Palas Biswas, Ambra Giannetti, Nandini Basumallick, Francesco Baldini, Somnath Bandyopadhyay and Sara Tombelli
Biosensors 2023, 13(7), 731; https://doi.org/10.3390/bios13070731 - 13 Jul 2023
Viewed by 923
Abstract
A methodology to enhance the sensitivity of long-period fiber gratings (LPFGs) based on the combination of three different enhancement approaches is presented; the methods here adopted are the working near mode transition (MT) of a cladding mode (CM), working near the turn-around point [...] Read more.
A methodology to enhance the sensitivity of long-period fiber gratings (LPFGs) based on the combination of three different enhancement approaches is presented; the methods here adopted are the working near mode transition (MT) of a cladding mode (CM), working near the turn-around point of a CM and the enhancement of the evanescent field of CMs by reducing the cladding diameter or by increasing the order number of CMs. In order to combine these enhancement methodologies, an electrostatic self-assembly (ESA) process was used to deposit a polymeric overlay, with a chosen thickness, onto the etched fiber. The add-layer sensitivity of the sensor was theoretically calculated, and the demonstration of the real applicability of the developed LPFG as a biosensor was performed by means of an IgG/anti-IgG immunoassay in human serum in a thermostated microfluidic system. The limits of detection (LODs) calculated by following different procedures (three times the standard deviation of the blank and the mean value of the residuals) were 6.9 × 10−8 µg/mL and 4.5 × 10−6 µg/mL, respectively. The calculated LODs demonstrate the effectiveness of the applied methodology for sensitivity enhancement. Full article
(This article belongs to the Special Issue Optical Biosensors for Label-Free Detection)
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