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Biomedicines
Special Issues
Emerging Trends in Wound Healing and Repair
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Emerging Trends in Wound Healing and Repair

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 5312

Special Issue Editors

Dr. Erica Costantini

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Guest Editor
Department of Medicine and Aging Science, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, Italy
Interests: inflammation; immunity; neurodegenerative diseases; neuroinflammation; anti-inflammatory effects of natural products; peripheral biomarkers research
Special Issues, Collections and Topics in MDPI journals
Dr. Marcella Reale

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Guest Editor
Department of Medical, Oral and Biotechnological Sciences, Unit of Immunodiagnostic and Molecular Pathology, University “G.d’Annunzio”, Via Dei Vestini 31, 66100 Chieti, Italy
Interests: neuroimmunology; inflammation; cytokines; non-neuronal cholinergic system; peripheral biomarkers of neurodegeneration; inflammation/autoimmunity
Special Issues, Collections and Topics in MDPI journals
Dr. Giulio Gualdi

E-Mail Website
Guest Editor
Department of Medicine and Aging Sciences, University of G. d'Annunzio Chieti and Pescara, Chieti, Italy
Interests: cutaneous lesions; conventional and non-conventional wound care techniques; cell cultures; skin cancer
Prof. Dr. Paolo Amerio

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Guest Editor
Department of Medicine and Aging Science, Dermatology Clinic, University “G. D’Annunzio”, Via dei Vestini, 66100 Chieti, Italy
Interests: general dermatology; photo-dermatology; immuno-dermatology; immune mediate skin diseases; psoriasis; atopic dermatitis; vitiligo; skin bullous diseases

Special Issue Information

Dear Colleagues,

At present, treatment for acute and chronic wounds represents a persistent and increasing medical and economic problem in our healthcare system. Valuable molecular insights and the development of innovative strategies for wound treatment are emerging and can help to create a bridge between basic or experimental research and clinical application. In this context, discussing the complexity of wound repair mediators and how they can be modulated through the application of advanced strategies can upgrade our knowledge, and is the aim of this Special Issue.

We are pleased to invite you to submit relevant original research and review articles including, but not limited to, the following topics:

  • Bioactive products, novel nutraceutical components (with defined molecular compounds), from animals and/or plants: anti-inflammatory and pro-regenerative properties for the treatment of wound healing.
  • Electromagnetic field: pulsed, static, extremely low or low frequency as a potential therapy for hard and soft tissue healing and regenerative processes.
  • Mechanistic investigations into the canonical and noncanonical regulatory pathways in wounds.
  • Natural and physical treatment effects on molecular mechanism alterations, as well as genetic and epigenetic regulation.

We look forward to receiving your contributions.

Dr. Erica Costantini
Dr. Marcella Reale
Dr. Giulio Gualdi
Prof. Dr. Paolo Amerio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • wound healing
  • tissue remodeling
  • natural approaches
  • physical approaches
  • molecular mechanisms
  • genetic
  • epigenetic

Published Papers (3 papers)

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Research

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12 pages, 2337 KiB  
Article
Development of Cellular Signaling Pathways by Bioceramic Heat Treatment (Sintering) in Osteoblast Cells
by Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin hye Chung and Jinhong Wie
Biomedicines 2023, 11(3), 785; https://doi.org/10.3390/biomedicines11030785 - 05 Mar 2023
Viewed by 1376
Abstract
Bioceramics are calcium-phosphate-based materials used in medical and dental implants for replacing or repairing damaged bone tissues; however, the effect of bioceramic sintering on the intracellular signaling pathways remains unknown. In order to address this, we analyzed the impact of sintering on the [...] Read more.
Bioceramics are calcium-phosphate-based materials used in medical and dental implants for replacing or repairing damaged bone tissues; however, the effect of bioceramic sintering on the intracellular signaling pathways remains unknown. In order to address this, we analyzed the impact of sintering on the cell signaling pathways of osteoblast cells using sintered and non-sintered hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). X-ray diffraction indicated that only the morphology of HA was affected by sintering; however, the sintered bioceramics were found to have elevated the calcium concentrations in relation to the non-sintered variants. Both bioceramics inhibited the JNK signaling pathway; the sintered HA exhibited half the value of the non-sintered variant, while the sintered β-TCP rarely expressed a p-JNK value. The total Src and Raptor protein concentrations were unaffected by the sintering, while the p-Src concentrations were decreased. The p-EGFR signaling pathway was regulated by the non-sintered bioceramics, while the p-p38 concentrations were reduced by both the sintered β-TCP and HA. All of the bioceramics attenuated the total AKT concentrations, particularly the non-sintered HA, and the AKT phosphorylation concentration, except for the non-sintered β-TCP. Thus, the sintering of bioceramics affects several intracellular signaling pathways. These findings may elucidate the bioceramic function and expand their application scope as novel substrates in clinical applications. Full article
(This article belongs to the Special Issue Emerging Trends in Wound Healing and Repair)
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14 pages, 1710 KiB  
Article
Impact of Wound Dressing on Mechanotransduction within Tissues of Chronic Wounds
by Kelly McElvain, Joshua Klister, Alessandra Ebben, Sandeep Gopalakrishnan and Mahsa Dabagh
Biomedicines 2022, 10(12), 3080; https://doi.org/10.3390/biomedicines10123080 - 30 Nov 2022
Cited by 1 | Viewed by 1617
Abstract
Chronic wounds are significant public health problems impacting the health-related quality of individuals’ lives (due to disability, decreased productivity, and loss of independence) and an immense economic burden to healthcare systems around the world. In this study, our main objective is to investigate [...] Read more.
Chronic wounds are significant public health problems impacting the health-related quality of individuals’ lives (due to disability, decreased productivity, and loss of independence) and an immense economic burden to healthcare systems around the world. In this study, our main objective is to investigate how mechanotransduction can impact the healing process in chronic wounds. We have developed new three-dimensional models of wound tissue to study the distribution of forces within these tissues exerted by wound dressings with different characteristics. The roles of mechanical forces on wound healing have gained significant clinical attention; the application of mechanical forces is expected to influence the physiology of tissue surrounding a wound. We aim to investigate whether the force transmission within wound tissue is impacted by the dressing characteristics and whether this impact may differ with wound tissue’s properties. Our results show that wound dressings with lower stiffnesses promote force transmission within a wound tissue. This impact is even more significant on stiffer wound tissues. Furthermore, we show that size of wound dressing alters forces that transmit within the wound tissue where dressings with 9 cm length show higher stresses. The wound tissue stiffening has been associated with healing of a wound. Our results demonstrate that wounds with stiffer tissue experience higher stresses. Taken all together, our findings suggest that low stiffness of wound dressing and its size may be introduced as a criterion to explain parameters predisposing a chronic wound to heal. This study’s findings on the role of dressings and tissue characteristics demonstrate that precision dressings are required for wound management and understanding how a dressing impacts mechanotransduction in wound tissue will lead to design of novel dressings promoting healing in chronic wounds. Full article
(This article belongs to the Special Issue Emerging Trends in Wound Healing and Repair)
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Review

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13 pages, 1947 KiB  
Review
Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing
by Filippo Renò and Maurizio Sabbatini
Biomedicines 2023, 11(3), 656; https://doi.org/10.3390/biomedicines11030656 - 21 Feb 2023
Cited by 3 | Viewed by 1585
Abstract
The lymphatic system is of fundamental importance in maintaining a fluid balance in the body and tissue homeostasis; it drains protein-rich lymph from the interstitial space and facilitates the release of cells that mediate the immune response. When one tissue is damaged, more [...] Read more.
The lymphatic system is of fundamental importance in maintaining a fluid balance in the body and tissue homeostasis; it drains protein-rich lymph from the interstitial space and facilitates the release of cells that mediate the immune response. When one tissue is damaged, more cells and tissues work to repair the damaged site. Blood and lymph vessels are particularly important for tissue regeneration and healing. Angiogenesis is the process of the formation of new blood vessels and is induced by angiogenic factors such as VEGF-A; VEGF-C/D-induced lymphangiogenesis and both occur simultaneously during wound healing. After the inflammatory phase, lymphatic vessels suppress inflammation by aiding in the drainage of inflammatory mediators; thus, disorders of the lymphatic system often result in chronic and disabling conditions. It has recently been clarified that delayed wound healing, as in diabetes, can occur as a consequence of impaired lymphangiogenesis. In this review, we have highlighted recent advances in understanding the biology underlying lymphangiogenesis and its key role in wound healing, and the possibility of its pharmacological modulation as a novel therapeutic strategy for the treatment of chronic wounds. Full article
(This article belongs to the Special Issue Emerging Trends in Wound Healing and Repair)
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