Dear Colleagues,

Animal models are powerful tools for investigating the key principles and underlying mechanisms of diseases and disorders. The use of animal models has allowed us to conduct various types of experiments and interrogate the mechanisms underlying diseases and disorders in manners that are unfeasible and unthinkable to apply to human patients. The usefulness of any animal model depends on various parameters such as predictive validity, symptoms, similarity to human conditions, and tractability. To date, various mammalian and non-mammalian animal models of neurological disorders have been established and characterized. They reflect the genetics, behavioral, and/or electrophysiological phenotypes of human patients.

There are various neurological disorders but, in this issue, we are mainly focusing on five prominent disorders: Parkinson’s disease, Alzheimer’s disease, epilepsy, Huntington’s disease, and schizophrenia. This Special Issue will provide experimental evidence, updated views, and new treatment strategies regarding these disorders. Critical discussions on the advantages and limitations of animal models used to mirror these neurological disorders are also welcome. This Special Issue will cover original articles and reviews on every aspect of mammalian and non-mammalian animal models of Parkinson’s disease, Alzheimer’s disease, epilepsy, Huntington’s disease, and schizophrenia. This may include (but is not limited to) genetic, pharmacological, chemogenetic (such as DREADDs), and optogenetic models of neurological disorders. In this issue, we also encourage authors to submit work on rare neurological and developmental disorders which affect the brain, spinal cord, or peripheral nerves.

Moreover, we encourage submissions on novel tools and methods related to animal models of the abovementioned neurological disorders as well. Tools and methods will only be considered if they are novel, well documented, discussed, and have the potential to be useful to the scientific world.

Prof. Dr. Marc Ekker
Dr. Sandesh Panthi
Guest Editors

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• animal model of neurological disorders
• Parkinson’s disease
• Alzheimer’s disease
• epilepsy
• seizures
• Huntington’s disease
• schizophrenia

• Animal Models of Neurological Disorders: Where Are We Now? in Biomedicines (9 articles)