Special Issue "The Use of Chemogenetics and Optogenetics on Understanding the Neurobiology of Brain Disorders"

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: 6 June 2025 | Viewed by 194

Special Issue Editors

Department of Zoology, Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand
Interests: epilepsy; seizures; chemogenetics; animal model of neurological disorder; animal model of epilepsy
Special Issues, Collections and Topics in MDPI journals
Department of Biology, Faculty of Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Interests: brain development and regeneration; development of dopamine and GABA neurons; control of gene expression; transgenic models; evolution of developmental mechanisms; zebrafish models of disease including Parkinson's disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Different techniques have been developed and optimized over preceding decades to selectively control specific populations of cells. Chemogenetics and optogenetics are the most widely used and technically successful tools. Since their discovery in early 2000, they have transformed neuroscience. These tools have allowed researchers to selectively target specific neuronal population/circuits to understand brain activity and behavior. As a discipline, chemogenetics uses engineered receptors and exogenous molecules specific to these receptors. Optogenetics, on the other hand, uses light-sensitive channels. Both approaches have their own advantages and limitations.

In this Special Issue, we encourage authors to submit original research papers, review articles and novel methods detailing the use of chemogenetics and/or optogenetics to understand the mechanisms behind brain-related disorders. Technical reviews which focus on the current progress and advancement of these tools are also welcome.

Dr. Sandesh Panthi
Prof. Dr. Marc Ekker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chemogenetics
  • optogenetics
  • brain disorders
  • neurobiology of disease

Published Papers

This special issue is now open for submission.
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