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Biomedicines
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Recent Advances in Oral Medicine
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Recent Advances in Oral Medicine

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 4470

Special Issue Editors

Dr. Arkadiusz Dziedzic

E-Mail Website
Guest Editor
Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry in Zabrze, SUM, Medical University of Silesia in Katowice, Pl. Akademicki 17, 41-902 Bytom, Poland
Interests: oral medicine; head and neck cancer; oral pathology; oral manifestations of systemic diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Robert Kubina

E-Mail Website
Guest Editor
1. Department of Pathology, Medical University of Silesia, Katowice, Poland
2. Silesia LabMed: Centre for Research and Implementation, Katowice, Poland
Interests: use of natural product in the treatment in neoplastic diseases; mechanism of biological activity of natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to invite you to submit your latest research and insights for consideration to a Special Issue on oral medicine, an interdisciplinary field that focuses on the diagnosis and treatment of oral diseases and conditions that affect the mouth and surrounding structures. This Special Issue aims to provide a platform for the dissemination of high-quality research that advances the understanding and treatment of oral diseases. We welcome submissions from researchers, clinicians, and academics from around the world who are working in areas related to oral medicine, including, but not limited to:

  • Oral cancer, benign oral neoplasms, and reactive oral pathologies;
  • Salivary gland disorders;
  • Orofacial pain;
  • Oral mucosa diseases;
  • Periodontal diseases;
  • Hereditary oro-facial disturbances,

We also encourage submissions that address broader topics, such as oral health disparities and emerging technologies and techniques. We welcome contributions from a broad range of topics related to oral pathology, oral microbiology, oral oncology, oral immunology, and oro-facial manifestations of systemic diseases. Authors are encouraged to submit original research and reviews that address important questions in oral medicine.

The global increase in polypharmacy and multidirectional interactions is deemed to induce or aggravate allergic/autoimmune reactions affecting oral health. In addition, novel systemic therapies based on monoclonal antibodies, CAR-T/CRISPR biotechnology, and bisphosphonates can impact the function/integrity of oral tissue. Inevitably, it is predicted that demographic change and extended life spans are risk factors of more prevalent oral pathologies in medically compromised individuals afflicted with complex underlying conditions. Lastly, in the light of COVD-19 pandemic, some infectious systemic diseases possess a real threat to the oral environment.   

Dr. Arkadiusz Dziedzic
Dr. Robert Kubina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • oral manifestations of systemic conditions
  • drug-induced lesions
  • oral pathologies
  • head and neck cancer
  • autoimmune
  • oral lesions
  • bisphosphonates
  • systemic pharmacotherapy
  • infectious diseases

Published Papers (3 papers)

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11 pages, 1072 KiB  
Communication
The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma
by Karolina Gołąbek, Dorota Hudy, Jadwiga Gaździcka, Katarzyna Miśkiewicz-Orczyk, Magdalena Nowak-Chmura, Marek Asman, Katarzyna Komosińska-Vassev, Wojciech Ścierski, Wojciech Golusiński, Maciej Misiołek and Joanna Katarzyna Strzelczyk
Biomedicines 2023, 11(11), 3053; https://doi.org/10.3390/biomedicines11113053 - 14 Nov 2023
Viewed by 863
Abstract
MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse the expression of the MDM2 target miRNA candidates (miR-3613-3p, miR-371b-5p [...] Read more.
MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse the expression of the MDM2 target miRNA candidates (miR-3613-3p, miR-371b-5p and miR-3658) and the MDM2 gene in oral squamous cell carcinoma tumour and margin samples and their association with the selected socio-demographic and clinicopathological characteristics. The study group consisted of 50 patients. The miRNAs and MDM2 gene expression levels were assessed by qPCR. The expression analysis of the miRNAs showed the expression of only one of them, i.e., miR-3613-3p. We found no statistically significant differences in the miR-3613-3p expression in tumour samples compared to the margin samples. When analysing the effect of smoking on miR-3613-3p expression, we demonstrated a statistically significant difference between smokers and non-smokers. In addition, we showed an association between the miR-3613-3p expression level and some clinical parameters in tumour samples (T, N and G). Our study demonstrates that miR-3613-3p overexpression is involved in the tumour progression of OSCC. This indicates that miR-3613-3p possesses potential prognostic values. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine)
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14 pages, 2898 KiB  
Article
Estimation of Cancellous Changes Using Fractal Analysis in Patients with Periodontitis
by Sukanya Mishra, Manoj Kumar, Lora Mishra, Swagatika Panda, Saurav Panda, Natalia Lewkowicz and Barbara Lapinska
Biomedicines 2023, 11(9), 2547; https://doi.org/10.3390/biomedicines11092547 - 16 Sep 2023
Cited by 1 | Viewed by 964
Abstract
Periodontal disease is a broad term given when the periodontium is affected by inflammation. There are several methods to diagnose periodontitis, but no method to quantify the cancellous bone is presently used. For this purpose, a non-invasive tool that is efficient in analyzing [...] Read more.
Periodontal disease is a broad term given when the periodontium is affected by inflammation. There are several methods to diagnose periodontitis, but no method to quantify the cancellous bone is presently used. For this purpose, a non-invasive tool that is efficient in analyzing bone quality called fractal analysis can be employed. The objective of the study was to utilize fractal dimension (FD) to evaluate cancellous patterns of interproximal alveolar bone using a digital intraoral periapical radiograph (IOPAR) in different clinical presentations of periodontitis classified according to the latest classification by the World Workshop for Periodontal and Peri-Implant Diseases and Conditions, 2017 (WWDC, 2017). The study aimed to numerically calculate the periodontitis changes in the cancellous bone around the affected tooth on an IOPAR using fractal analysis and to provide an additional criterion for the staging of periodontitis. In this cross-sectional observational study, 75 patients were selected and equally allotted to five groups based on the staging system proposed by the WWDC, 2017. The region of interest was selected on the IOPA radiograph of the tooth with the site having the most significant clinical attachment loss, and FD was calculated using Image J analysis. The association of gender and age with stages of periodontitis was studied using the chi-square test of independence. A comparison of % bone loss and fractal dimension among stages was studied by using the non-parametric Kruskal Wallis test. The relationship between % bone loss and fractal dimension within stages and gender was studied by using the Karl Pearson correlation. A receiver operating characteristic (ROC) curve analysis was performed for FD value as a marker of periodontitis patients. We demonstrated that the FD values decreased significantly with the increase in stages (p < 0.0001). The overall relationship between % bone loss and FD showed a significantly strong negative correlation of −0.739 (p < 0.0001), except for stages III and IV. FD can be utilized as a quantitative method for detecting cancellous bone changes in different stages of periodontitis, aiding in diagnosing periodontitis. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine)
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Other

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16 pages, 1888 KiB  
Case Report
Oral Lesions as the Primary Manifestations of Behçet’s Disease: The Importance of Interdisciplinary Diagnostics—A Case Report
by Alvaro Cavalheiro Soares, Fabio Ramoa Pires, Nara Regina de Oliveira Quintanilha, Lilian Rocha Santos, Thaylla Nunez Amin Dick, Arkadiusz Dziedzic and Bruna Lavinas Sayed Picciani
Biomedicines 2023, 11(7), 1882; https://doi.org/10.3390/biomedicines11071882 - 03 Jul 2023
Cited by 1 | Viewed by 2141
Abstract
Background: Behçet’s disease (BD) is a rare chronic auto-inflammatory systemic disease with non-specific oral manifestations, categorised as generalised variable vessel vasculitis that requires an interdisciplinary approach to diagnose due to its phenotypic heterogeneity. Whilst the oral lesions that reoccur in BD underpin the [...] Read more.
Background: Behçet’s disease (BD) is a rare chronic auto-inflammatory systemic disease with non-specific oral manifestations, categorised as generalised variable vessel vasculitis that requires an interdisciplinary approach to diagnose due to its phenotypic heterogeneity. Whilst the oral lesions that reoccur in BD underpin the complex diagnostic process, the crucial role of dental professionals is highlighted in a case report summarised herein. We present a case of a 47-year-old male referred to the Oral Medicine Department by a rheumatologist after previous hospitalization for thrombosis of the iliac vein and inferior vena cava. He had elevated inflammatory C-reactive protein biomarker and an increased erythrocyte sedimentation rate. Recurrent episodes of folliculitis, oral and genital ulcers were reported. Clinical examination revealed multiple ulcerations in the oral mucosa. The complementary, histopathological analysis performed to rule out other disorders, based on excisional biopsy, showed non-keratinised stratified squamous epithelium with areas of exocytosis and ulceration. The connective tissue presented an intense mixed inflammatory infiltrate, congested blood vessels, haemorrhage, vasculitis, and HLA-B genotyping identified the expression of HLA-B15, further supporting the BD diagnosis. Treatment was initiated with colchicine, prednisolone, and weekly subcutaneous administration of methotrexate and resulted in the complete remission of oral lesions and no recurrence of other manifestations. Conclusions: This BD case report emphasizes the importance of a multidisciplinary approach in diagnosing BD, including the use of histopathological assessment and genetic profiling. It highlights the significance of thorough intraoral assessment and referral to a multidisciplinary team for diagnosis. The oral manifestations of BD as the primary symptoms often indicate underlying major systemic pathologies. The authors stress the need for a structured diagnostic algorithm to facilitate timely and effective management of BD. Full article
(This article belongs to the Special Issue Recent Advances in Oral Medicine)
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