Aging and Neuroendocrinological Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2460

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Health Sciences (Ceuta), University of Granada, 51001 Ceuta, Spain
Interests: molecular neurobiology; brain pathology; diabetic; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biomedicine, Biotechnology and Public Health, Biochemistry and Molecular Biology Area, Faculty of Science, University of Cádiz. Av República Saharaui s/n, 11510 Puerto Real, Cádiz, Spain
Interests: Atherosclerosis; Diabetes; Obesity; Insulin Resistance

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Guest Editor
Department of Biomedicine, Biotechnology and Public Health, Physiology Area, Faculty of Medicine, University of Cádiz; Pl. Falla, 9, 11003 Cádiz, Spain
Interests: neurodegeneration; motoneuron; excitability; amyotrophic lateral sclerosis; neuroelectrophysiology

Special Issue Information

Dear Colleagues,

Physiology disbalance and pathogenesis of central nervous system play an important role in the quality of people life and aging. In the last few years epidemiological and clinical studies have identified different metabolic alterations as risks factors to develop neurodegenerative processes. Following this idea diabetes mellitus, obesity and sedentary live seems to play a relevant role at this level. Nevertheless, science studies are limited and the underlying mechanisms for this relationship remain largely unknown (metabolic disorders-neurodegenerative process). This special issue will publish original research articles as well as mini and full reviews, including perspectives in the field on the current understanding of molecular mechanisms involved in pathogenesis of diseases of the Central Nervous System. Manuscripts on the molecular mechanisms, introduction of ideas for new therapies or new techniques for diagnosis and treatment of diseases of the central nervous system are welcome.

Dr. Juan José Ramos-Rodríguez
Dr. Margarita Jimenez-Palomares
Dr. Victoria Garcia-Morales
Guest Editors

Manuscript Submission Information

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Keywords

  • psychoneuroendocrinology
  • metabolic dysregulation
  • atherosclerosis
  • diabetes
  • obesity
  • insulin resistance
  • neuronal death
  • neuronal excitotoxicity
  • neuronal dysfunction
  • dementia
  • nephropathy
  • brain atrophy

Published Papers (1 paper)

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Research

12 pages, 1096 KiB  
Article
Poor Cognitive Agility Conservation in Obese Aging People
by Teresa Pardo-Moreno, Himan Mohamed-Mohamed, Antonio Rivas-Dominguez, Victoria Garcia-Morales, Ruben A. Garcia-Lara, Sami Suleiman-Martos, Beatriz Bermudez-Pulgarin and Juan Jose Ramos-Rodriguez
Biomedicines 2023, 11(1), 138; https://doi.org/10.3390/biomedicines11010138 - 5 Jan 2023
Cited by 3 | Viewed by 2089
Abstract
Life expectancy has been boosted in recent decades at expenses of increasing the age-associated diseases. Dementia, for its incidence, stands out among the pathologies associated with aging. The exacerbated cognitive deterioration disables people from carrying out their daily lives autonomously and this incidence [...] Read more.
Life expectancy has been boosted in recent decades at expenses of increasing the age-associated diseases. Dementia, for its incidence, stands out among the pathologies associated with aging. The exacerbated cognitive deterioration disables people from carrying out their daily lives autonomously and this incidence increases exponentially after 65 years of age. The etiology of dementia is a miscellaneous combination of risk factors that restrain the quality of life of our elderly. In this sense, it has been established that some metabolic pathologies such as obesity and diabetes act as a risk factor for dementia development. In contrast, a high educational level, as well as moderate physical activity, have been shown to be protective factors against cognitive impairment and the development of dementia. In the present study, we have evaluated the metabolic composition of a population between 60–90 years old, mentally healthy and with high academic degrees. After assessing agility in mental state, we have established relationships between their cognitive abilities and their body composition. Our data support that excess body fat is associated with poorer maintenance of cognition, while higher percentages of muscle mass are associated with the best results in the cognitive tests. Full article
(This article belongs to the Special Issue Aging and Neuroendocrinological Diseases)
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