Neuromodulation: Emerging Medical Therapies

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2884

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Guest Editor
Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USA
Interests: neuromodulation; pain; discogenic pain; knee degenerative disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As an emerging class of medical therapies, neuromodulation uses implantable or non-implantable technology to change the activity of the central nervous system, peripheral nervous system or autonomic nervous system by means of electrical stimulation or drugs, so as to improve the symptoms of patients and improve their quality of life. Neuromodulation can be applied to many types of pain, epilepsy, Parkinson's disease, mental disease, angina pectoris, irritable bowel syndrome and diseases caused by peripheral neuropathy. The field of neuromodulation has significantly advanced in the past few decades in both hardware and software capabilities. Those advances led to improvements in patient outcomes and a reduction in adverse events and complications. The advancement of the technology is continuous and moving fast. This Special Issue is intended to discuss new innovations in neuromodulation including implantable devices, non-implantable devices, pulsed radiofrequency ablation and more.

Dr. Alaa Abd-Elsayed
Guest Editor

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Keywords

  • neuroregulation
  • implantable devices
  • non-implantable devices
  • radiofrequency ablation
  • neurostimulators

Published Papers (1 paper)

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16 pages, 1230 KiB  
Systematic Review
Neuromodulation for Peripheral Nerve Regeneration: Systematic Review of Mechanisms and In Vivo Highlights
by Max Y. Jin, Tristan E. Weaver, Adam Farris, Mayank Gupta and Alaa Abd-Elsayed
Biomedicines 2023, 11(4), 1145; https://doi.org/10.3390/biomedicines11041145 - 10 Apr 2023
Cited by 5 | Viewed by 2675
Abstract
While denervation can occur with aging, peripheral nerve injuries are debilitating and often leads to a loss of function and neuropathic pain. Although injured peripheral nerves can regenerate and reinnervate their targets, this process is slow and directionless. There is some evidence supporting [...] Read more.
While denervation can occur with aging, peripheral nerve injuries are debilitating and often leads to a loss of function and neuropathic pain. Although injured peripheral nerves can regenerate and reinnervate their targets, this process is slow and directionless. There is some evidence supporting the use of neuromodulation to enhance the regeneration of peripheral nerves. This systematic review reported on the underlying mechanisms that allow neuromodulation to aid peripheral nerve regeneration and highlighted important in vivo studies that demonstrate its efficacy. Studies were identified from PubMed (inception through September 2022) and the results were synthesized qualitatively. Included studies were required to contain content related to peripheral nerve regeneration and some form of neuromodulation. Studies reporting in vivo highlights were subject to a risk of bias assessment using the Cochrane Risk of Bias tool. The results of 52 studies indicate that neuromodulation enhances natural peripheral nerve regeneration processes, but still requires other interventions (e.g., conduits) to control the direction of reinnervation. Additional human studies are warranted to verify the applicability of animal studies and to determine how neuromodulation can be optimized for the greatest functional restoration. Full article
(This article belongs to the Special Issue Neuromodulation: Emerging Medical Therapies)
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