Targeted Drug Delivery for the Chronic Pain Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 270

Special Issue Editors

E-Mail Website
Guest Editor
Nura Pain Clinics, Edina, MN 55435, USA
Interests: interventional pain; pain management

E-Mail Website
Guest Editor
Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USA
Interests: neuromodulation; pain; discogenic pain; knee degenerative disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Complex chronic pain is a management challenge for primary care providers and physician pain specialists alike. When a chronic pain patient fails to respond to medication management, physical therapy, interventional pain procedures, and even surgeries, implantable pain control becomes a viable option with neurostimulation and targeted spinal drug delivery comprising the two widely available implantable options.

Pain pumps implanted for targeted spinal drug delivery have significantly higher risks compared to neurostimulation systems but are often more effective for the most complex pain problems—pain with nociceptive components, diffuse pain, cancer pain, and pain syndromes for which neurostimulation trials and/or implants have failed. While neurostimulation is widely practiced by many pain specialists worldwide, pain pumps are much less popular and are implanted and managed by a relatively small group of specialists. This Special Issue aims to examine the evidence basis for pain pumps and their effectiveness for a myriad of pain problems that have failed all other management and discusses the reasons that targeted drug delivery may be an underutilized therapy.

Prof. Dr. David M. Schultz
Dr. Alaa Abd-Elsayed
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic pain
  • targeted spinal drug delivery

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop