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Biomedicines
Special Issues
Engineered Nanomaterials for Diagnosis, Prevention and Therapy
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Engineered Nanomaterials for Diagnosis, Prevention and Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Nanomedicine and Nanobiology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1769

Special Issue Editor

Dr. Aniruddha Adhikari

E-Mail Website
Guest Editor
Department of Chemical and Biomolecular Engineering, University of California at Los Angeles (UCLA), Los Angeles, CA, USA
Interests: nanomedicine; phage engineering; redox medicine; nano-bio interaction; nano toxicity

Special Issue Information

Dear Colleagues,

Biologically active engineered nanomaterials are indispensable tools in healthcare research, bringing innovative approaches to diagnosis, treatment, and disease management, and offering a transformative outlook. Their precise and targeted therapeutic capabilities hold promise for mitigating several unmet diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases, not to mention chronic hepatic and renal disorders. Biologically active nanomaterials can be engineered to deliver drugs, genes, or therapeutic agents with precision to specific cells or tissues, minimizing off-target effects and enhancing treatment efficacy. Notably, several of these nanomaterials can traverse biological barriers, such as the blood–brain barrier, enabling the treatment of previously inaccessible diseases and conditions. In addition, engineered nanomaterials can significantly contribute to diagnostics by enabling the development of highly sensitive and specific nano-based biosensors, imaging agents, and diagnostic tools. Therefore, in the face of an aging global population and the growing complexity of diseases, the potential of engineered nanomaterials to enhance drug delivery, diagnostics, and personalized medicine positions this topic as a pivotal field for advancing healthcare solutions. This Special Issue of Biomedicine is focused on the recent advances, methods, and approaches in preparing engineered nanomaterials and their applications in the diagnosis, prevention and therapy of diseases.

This Special Issue seeks to gather high-quality original research contributions, reviews, and perspectives from experts in the field, fostering collaboration and knowledge exchange among researchers, clinicians, and policymakers interested in the innovative use of nanomaterials to improve healthcare outcomes.

Suitable topics include, but are not limited to, the following:

  • Engineered nanomaterials for cancer therapy;
  • Engineered nanomaterials platform for viral infections;
  • Nanomedicine strategies for vaccine delivery;
  • Engineered nanomaterials for immune engineering;
  • Nanomedicine: Pharmacokinetics, Pharmacodynamics and Toxicity;
  • Engineered nanomaterials for topical and transdermal delivery;
  • Engineered nanomaterials for oral delivery;
  • Engineered nanomaterials for parenteral delivery;
  • Engineered nanomaterials as redox medicine;
  • Nanomedicine for ocular diseases;
  • Nanomedicine for diabetes and its complications;
  • Nanomedicine for inflammatory diseases;
  • Nanotherapeutic approaches targeting mitochondria;
  • Biosensors for disease diagnosis;
  • Implantable biosensors;
  • Nanotheranostic materials;
  • Engineered nanomaterials for wound healing.

Dr. Aniruddha Adhikari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • engineered nanomaterials
  • nanomedicine, biosensor
  • nanotheranostics
  • drug delivery
  • biomaterial
  • nanomaterial toxicity
  • nano-implantable device
  • redox medicine

Published Papers (2 papers)

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Research

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23 pages, 20255 KiB  
Article
Nanomaterials Based on 2,7,12,17-Tetra-tert-butyl-5,10,15,20-tetraaza-21H,23H-porphine Exhibiting Bifunctional Sensitivity for Monitoring Chloramphenicol and Co2+
by Ionela Fringu, Diana Anghel, Ion Fratilescu, Camelia Epuran, Mihaela Birdeanu and Eugenia Fagadar-Cosma
Biomedicines 2024, 12(4), 770; https://doi.org/10.3390/biomedicines12040770 - 30 Mar 2024
Viewed by 487
Abstract
Monitoring antibiotic retention in human body fluids after treatment and controlling heavy metal content in water are important requirements for a healthy society. Therefore, the approach proposed in this study is based on developing new optical sensors using porphyrin or its bifunctional hybrid [...] Read more.
Monitoring antibiotic retention in human body fluids after treatment and controlling heavy metal content in water are important requirements for a healthy society. Therefore, the approach proposed in this study is based on developing new optical sensors using porphyrin or its bifunctional hybrid materials made with AuNPs to accomplish the accurate detection of chloramphenicol and cobalt. To produce the new optical chloramphenicol sensors, 2,7,12,17-tetra-tert-butyl-5,10,15,20-tetraaza-21H,23H-porphine (TBAP) was used, both alone in an acid medium and as a hybrid material with AuNPs in a water–DMSO acidified environment. The same hybrid material in the unchanged water–DMSO medium was the sensing material used for Co2+ monitoring. The best results of the hybrid materials were explained by the synergistic effects between the TBAP azaporphyrin and AuNPs. Chloramphenicol was accurately detected in the range of concentrations between 3.58 × 10−6 M and 3.37 × 10−5 M, and the same hybrid material quantified Co2+ in the concentration range of 8.92 × 10−5 M–1.77 × 10−4 M. In addition, we proved that AuNPs can be used for the detection of azaporphyrin (from 2.66 × 10−5 M to 3.29 × 10−4 M), making them a useful tool to monitor porphyrin retention after cancer imaging procedures or in porphyria disease. In conclusion, we harnessed the multifunctionality of this azaporphyrin and of its newly obtained AuNP plasmonic hybrids to detect chloramphenicol and Co2+ quickly, simply, and with high precision. Full article
(This article belongs to the Special Issue Engineered Nanomaterials for Diagnosis, Prevention and Therapy)
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Review

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24 pages, 6874 KiB  
Review
Advancing Cancer Treatment: Enhanced Combination Therapy through Functionalized Porous Nanoparticles
by Kibeom Kim and Myoung-Hwan Park
Biomedicines 2024, 12(2), 326; https://doi.org/10.3390/biomedicines12020326 - 31 Jan 2024
Viewed by 1046
Abstract
Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination [...] Read more.
Cancer remains a major global health challenge, necessitating the development of innovative treatment strategies. This review focuses on the functionalization of porous nanoparticles for combination therapy, a promising approach to enhance cancer treatment efficacy while mitigating the limitations associated with conventional methods. Combination therapy, integrating multiple treatment modalities such as chemotherapy, phototherapy, immunotherapy, and others, has emerged as an effective strategy to address the shortcomings of individual treatments. The unique properties of mesoporous silica nanoparticles (MSN) and other porous materials, like nanoparticles coated with mesoporous silica (NP@MS), metal–organic frameworks (MOF), mesoporous platinum nanoparticles (mesoPt), and carbon dots (CDs), are being explored for drug solubility, bioavailability, targeted delivery, and controlled drug release. Recent advancements in the functionalization of mesoporous nanoparticles with ligands, biomaterials, and polymers are reviewed here, highlighting their role in enhancing the efficacy of combination therapy. Various research has demonstrated the effectiveness of these nanoparticles in co-delivering drugs and photosensitizers, achieving targeted delivery, and responding to multiple stimuli for controlled drug release. This review introduces the synthesis and functionalization methods of these porous nanoparticles, along with their applications in combination therapy. Full article
(This article belongs to the Special Issue Engineered Nanomaterials for Diagnosis, Prevention and Therapy)
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