Oxidative Stress and Inflammation in Non-communicable Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1511

Special Issue Editors


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Guest Editor
Department of Physiology, Anatomy and Neuroscience, University of Szeged, H-6726 Szeged, Hungary
Interests: cardiovascular diseases; aging; lifestyle modifications; oxidative stress; inflammation
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Co-Guest Editor
Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary
Interests: cardiovascular diseases; physical exercise; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-communicable diseases (NCDs) are among the leading causes of death worldwide. NCDs comprise a large spectrum of diseases, including cardiovascular, chronic respiratory and neurological diseases, cancer, diabetes, obesity-related conditions and even infertility. Although the etiology of NCDs is as diverse as the spectrum of diseases, a growing number of studies have verified that many of these diseases share common pathophysiological mechanisms. These studies underpin that mitochondrial alterations, oxidative stress and inflammation play key roles in the onset and development of NCDs. Therefore, the pharmacological or nutritional manipulation of oxidative and inflammatory processes and targets can prevent, improve or delay the progression of NCDs, which can eventually lead to a decrease in the mortality and morbidity associated to NCDs.

This Special Issue focuses on the current understanding and future research directions regarding the role of oxidative stress and inflammation in NCDs. We warmly welcome original research, including animal research, preclinical data, as well as review articles relating to this hot topic.

Potential topics include, but are not limited to:

  • Identification and examination of new signaling pathways related to the onset and progression of NCDs;
  • Preventive and therapeutic approaches in NCDs;
  • The role of natural and synthetic antioxidants in modulating oxidative stress and inflammation;
  • Aging as a risk factor for the development of NCDs.

Dr. Renáta Szabó
Dr. Denise Börzsei
Guest Editors

Manuscript Submission Information

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Keywords

  • oxidative stress
  • inflammation
  • antioxidant therapy
  • aging
  • cardiovascular diseases
  • infertility
  • metabolic diseases
  • cancer

Published Papers (1 paper)

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Review

15 pages, 1362 KiB  
Review
Mechanisms and Target Parameters in Relation to Polycystic Ovary Syndrome and Physical Exercise: Focus on the Master Triad of Hormonal Changes, Oxidative Stress, and Inflammation
by Csanád Endre Lőrincz, Denise Börzsei, Alexandra Hoffmann, Csaba Varga and Renáta Szabó
Biomedicines 2024, 12(3), 560; https://doi.org/10.3390/biomedicines12030560 - 01 Mar 2024
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Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads [...] Read more.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among females of reproductive age with heterogeneous prevalence. It is well known that female reproductive competence depends on the dynamic regulation of the hypothalamic–pituitary–gonadal (HPG) axis; therefore, disruption of this highly regulated system leads to fertility problems. Among disruptors, both oxidative stress and inflammation contribute to an increased LH-FSH ratio and a consequent hyperandrogenism. Shifts in this bidirectional interplay between the neuroendocrine system and oxidative/inflammatory homeostasis result in the accumulation of reactive oxygen/nitrogen species and inflammatory markers as well as alterations in antioxidant defense mechanisms. Evidence shows that lifestyle changes, including regular physical exercise, are recognized as the most effective first-line management to reduce the severity of PCOS symptoms. The aim of our narrative review is to provide insights into the mechanisms and target factors of PCOS-related hormonal changes, oxidative/antioxidant homeostasis, and inflammation, and to discuss the effects of exercise, which takes into account various factors, in relation to PCOS. A better understanding of the PCOS-associated hormonal changes, oxidative and inflammatory circuits, as well as exercise-induced mechanisms of action on those targets may improve the quality of life of women with PCOS. Full article
(This article belongs to the Special Issue Oxidative Stress and Inflammation in Non-communicable Diseases)
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