Telomerase and Telomeres: Role in Health and Aging, Volume II
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 7578
Special Issue Editor
Interests: telomerase; telomeres; aging; senescence-associated pathologies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The history of the prediction, discovery, and study of telomerase is reminiscent of a thriller that has been unfolding before us for over 100 years. Back in the 1990s, new biotech firms popped up every day like mushrooms after the rain; the hope that immortality could be achieved for the human body was associated with the management of cellular immortality. This hope did not come true, but it did make it possible to formulate further goals more clearly. Today, we are far less concerned with extending life; instead, a perhaps more noble goal has arisen: increasing the length of a healthy life. Interestingly, telomerase is again able to influence the processes involved in this effort in the most unpredictable ways.
The aim of this Special Issue is to summarize the knowledge of telomerase functions and its role in the pathophysiology of aging-associated diseases and cancer.
Topics of the Special Issue include but are not limited to the following:
- Telomerase and mitochondria, redox regulation;
- Non-canonical functions of telomerase;
- Telomerase, telomeres, SASP;
- Inflamm-aging, senolytics;
- Special role of telomerase in neurons;
- Telomerase and cancer: Features of hTERT repression, fusion-bridge-breakage mechanism, circular chromosomes, and chromothripsis;
- Telomerase, lifespan, body size;
- Telomere position effect;
- Telomeropathies: diskeratosis congenita, interstitial pulmonary fibrosis, etc.;
- Telomere measurement methods: comparisons;
- G4 structures: role in telomeres and whole genome;
- Splicing hTERT as a regulator.
Prof. Dr. Yegor E. Yegorov
Guest Editor
Manuscript Submission Information
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Keywords
- telomerase
- telomeres
- SASP
- redox regulation
- non-canonical functions of telomerase
- inflamm-aging
- senolytics
- cancer
- lifespan
- healthspan
- telomeropathies
- G4 structures
Related Special Issue
- Telomerase: Role in Health and Aging in Biomedicines (14 articles)
