Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.0
4.2
Journals
Biology
Special Issues
Physiological and Pathophysiological Responses to Biomaterials
share announcement

Physiological and Pathophysiological Responses to Biomaterials

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 5693

Special Issue Editors

Dr. Amilcare Barca

E-Mail Website1 Website2
Guest Editor
Department of Biological and Environmental Sciences and Technologies (DeBEST), Università del Salento, Via per Monteroni c/o Ecotekne, 73100 Lecce, Italy
Interests: cell physiology; comparative and applied physiology; cellular homeostasis; transmembrane transport processes/systems; solute carriers (SLC); epithelial physiology; epithelial cell models; oligopeptides; immunity and inflammation; animal models; zebrafish; cytotoxicity; cell–material interactions; biomaterials; tissue engineering; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Madaghiele

E-Mail Website
Guest Editor
Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: polymeric devices for biomedical applications, including scaffolds for regenerative medicine, micro- and nano-particles for controlled drug delivery, wound dressings, and perm-selective barriers for cell encapsulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, in the context of advanced biomaterial applications, such as tissue regeneration/mimicry, healing and controlled release of pharmacological molecules, the intertwinement of molecular physiology and tissue engineering approaches has led to elucidating and defining many mechanisms of cell-material and tissue-material interactions. Nevertheless, the increasing investigations on new biomaterials formulations and biomedical devices at the nano-, meso- or microscale level imply the identification of new types of impact and extremely diverse responses from cells and tissues, which may vary upon the physiological or pathophysiological processes which the biomaterial/device must face.

In this Special Issue, we invite the submission of original scientific reports, research articles, communications and review articles, on the broad topic of cell-material and tissue-material interactions at nano-, meso- or microscale levels, investigated with respect to a) the physiological processes inherent in the use of biomaterials in pathophysiological contexts, and b) the description of basic structure-function relationships of biomaterials and biomedical devices with cells and tissues.

With this Special Issue, we aim at describing a shared overview of the essential framework of physiological responses triggered by currently investigated biomaterials (including polymers, metals, ceramics and composites), pointing out both convergent and divergent pathways on the two-way physiological-pathophysiological route. In this view, we seek giving usefully a transdisciplinary contribution to better shape the physiological context at the interface between cells/tissues and biomaterials.

Dr. Amilcare Barca
Dr. Marta Madaghiele
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular stimuli and physiological responses
  • plasma membrane interface
  • cell-material interactions
  • tissue-material interactions
  • tissue engineering
  • biomaterials
  • biomedical device
  • structure-function relationship

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 2558 KiB  
Communication
Evidence of Modular Responsiveness of Osteoblast-Like Cells Exposed to Hydroxyapatite-Containing Magnetic Nanostructures
by Stefania Scialla, Barbara Palazzo, Alessandro Sannino, Tiziano Verri, Francesca Gervaso and Amilcare Barca
Biology 2020, 9(11), 357; https://doi.org/10.3390/biology9110357 - 25 Oct 2020
Cited by 5 | Viewed by 2131
Abstract
The development of nanocomposites with tailored physical–chemical properties, such as nanoparticles containing magnetic iron oxides for manipulating cellular events at distance, implies exciting prospects in biomedical applications for bone tissue regeneration. In this context, this study aims to emphasize the occurrence of differential [...] Read more.
The development of nanocomposites with tailored physical–chemical properties, such as nanoparticles containing magnetic iron oxides for manipulating cellular events at distance, implies exciting prospects in biomedical applications for bone tissue regeneration. In this context, this study aims to emphasize the occurrence of differential responsiveness in osteoblast-like cells to different nanocomposites with diverse features: dextran-grafted iron oxide (DM) nanoparticles and their hybrid nano-hydroxyapatite (DM/n-HA) counterpart. Here, responsiveness of cells in the presence of DMs or DM/n-HAs was evaluated in terms of cytoskeletal features. We observed that effects triggered by the DM are no more retained when DM is embedded onto the DM/n-HA nanocomposites. Also, analysis of mRNA level variations of the focal adhesion kinase (FAK), P53 and SLC11A2/DMT1 human genes showed that the DM/n-HA-treated cells retain tracts of physiological responsiveness compared to the DM-treated cells. Overall, a shielding effect by the n-HA component can be assumed, masking the DM’s cytotoxic potential, also hinting a modular biomimicry of the nanocomposites respect to the physiological responses of osteoblast-like cells. In this view, the biocompatibility of n-HA together with the magnetic responsiveness of DMs represent an optimized combination of structural with functional features of the DM/n-HA nano-tools for bone tissue engineering, for finely acting within physiological ranges. Full article
(This article belongs to the Special Issue Physiological and Pathophysiological Responses to Biomaterials)
►▼ Show Figures

Figure 1

15 pages, 4839 KiB  
Article
Assessment of Cytocompatibility and Anti-Inflammatory (Inter)Actions of Genipin-Crosslinked Chitosan Powders
by Simona Dimida, Matteo Santin, Tiziano Verri, Amilcare Barca and Christian Demitri
Biology 2020, 9(7), 159; https://doi.org/10.3390/biology9070159 - 08 Jul 2020
Cited by 4 | Viewed by 2714
Abstract
Chitosan is a polysaccharide commonly used, together with its derivatives, in the preparation of hydrogel formulations, scaffolds and films for tissue engineering applications. Chitosan can be used as such, but it is commonly stabilized by means of chemical crosslinkers. Genipin is one of [...] Read more.
Chitosan is a polysaccharide commonly used, together with its derivatives, in the preparation of hydrogel formulations, scaffolds and films for tissue engineering applications. Chitosan can be used as such, but it is commonly stabilized by means of chemical crosslinkers. Genipin is one of the crosslinkers that has been considered that is a crystalline powder extracted from the fruit of Gardenia jasminoides and processed to obtain an aglycon compound. Genipin is gaining interest in biological applications because of its natural origin and anti-inflammatory actions. In this paper, the ability of chitosan-based materials crosslinked with genipin to exert anti-inflammation properties in applications such as bone regeneration was studied. Powders obtained from chitosan–genipin scaffolds have been tested in order to mimic the natural degradation processes occurring during biomaterials implantation in vivo. The results from osteoblast-like cells showed that specific combinations of chitosan and genipin stimulate high permissiveness towards cells, with higher performance than the pure chitosan. In parallel, evidences from monocyte-like cells showed that the crosslinker, genipin, seems to promote slowing of the monocyte-macrophage transition at morphological level. This suggests a sort of modularity of pro-inflammatory versus anti-inflammatory behavior of our chitosan-based biomaterials. Being both the cell types exposed to microscale powders, as an added value our results bring information on the cell–material interactions in the degradative dynamics of chitosan scaffold structures during the physiological resorption processes. Full article
(This article belongs to the Special Issue Physiological and Pathophysiological Responses to Biomaterials)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop