Special Issue "Nanofibrous Scaffolds Application in Biomedicine"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 1207

Special Issue Editors

Department of Engineering for Innovation, Campus Ecotekne, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: nanofibrous; electrospinning; polymer and ceramic scaffold; tissue engineering
Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: polymeric devices for biomedical applications, including scaffolds for regenerative medicine, micro- and nano-particles for controlled drug delivery, wound dressings, and perm-selective barriers for cell encapsulation
Special Issues, Collections and Topics in MDPI journals
Department of Engineering for Innovation, University of Salento, Via per Monteroni, 73100 Lecce, Italy
Interests: biomaterials; scaffold; tissue engineering; material characterization; viscoelasticity; hydrogels; green chemistry; natural polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanofibers are explored for a variety of biomedical applications such as carriers for drug/therapeutic agent delivery, wound dressing materials and as porous three-dimensional scaffolds for engineering various tissues such as skin, blood vessels, nerve, tendon, bone and cartilage. The continuous structure of nanofibers makes them more suitable for use as the basic component of a scaffold providing a connection between the nano and the macroscopic objects. The nanofibers present unique properties such as a high surface area to volume ratio, flexibility in surface functionalities, superior mechanical, high porosity, variable pore-size distribution and morphological similarity to fibrillar structure of native ECM. Among the techniques that allow the production of nanofibrous structures, electrospinning is certainly a promising one due to its simplicity, versatility and the development of new techniques and materials useful for tissue engineering and biomedicine applications.

The articles in this Special Issue will provide a platform for future research and innovation in the field of smart and functional nanofibrous electrospun scaffolds. We believe that this Special Issue will be of interest to researchers and practitioners in the field of biomaterials and bioengineering, as well as to those who are interested in the development of new and innovative technologies for nanofibrous scaffolds for biomedicine applications.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Smart nanofibrous scaffolds for tissue engineering.
  • Multifunctional nanofibers scaffold for regenerative medicine.
  • Chemical and physical functionalization of nanofibrous scaffold.
  • Unconventional nanofibrous materials for biomedicine.
  • New applications of nanofibers for biomedical devices.
  • Nanofibers for smart therapeutics treatments.
  • Nanofibrous scaffolds for drug delivery.

We look forward to receiving your contributions.

Dr. Paola Nitti
Dr. Marta Madaghiele
Dr. Christian Demitri
Guest Editors

Manuscript Submission Information

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Keywords

  • nanofibrous scaffolds
  • biomedicine
  • nanofibers functionalization
  • smart nanofibrous scaffold
  • new material for nanofibrous scaffold
  • nanofibers for drug delivery system

Published Papers (2 papers)

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Research

Article
Biomimetic Electrospun Self-Assembling Peptide Scaffolds for Neural Stem Cell Transplantation in Neural Tissue Engineering
Pharmaceutics 2023, 15(9), 2261; https://doi.org/10.3390/pharmaceutics15092261 - 31 Aug 2023
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Abstract
Spinal cord regeneration using stem cell transplantation is a promising strategy for regenerative therapy. Stem cells transplanted onto scaffolds that can mimic natural extracellular matrix (ECM) have the potential to significantly improve outcomes. In this study, we strived to develop a cell carrier [...] Read more.
Spinal cord regeneration using stem cell transplantation is a promising strategy for regenerative therapy. Stem cells transplanted onto scaffolds that can mimic natural extracellular matrix (ECM) have the potential to significantly improve outcomes. In this study, we strived to develop a cell carrier by culturing neural stem cells (NSCs) onto electrospun 2D and 3D constructs made up of specific crosslinked functionalized self-assembling peptides (SAPs) featuring enhanced biomimetic and biomechanical properties. Morphology, architecture, and secondary structures of electrospun scaffolds in the solid-state and electrospinning solution were studied step by step. Morphological studies showed the benefit of mixed peptides and surfactants as additives to form thinner, uniform, and defect-free fibers. It has been observed that β-sheet conformation as evidence of self-assembling has been predominant throughout the process except for the electrospinning solution. In vitro NSCs seeded on electrospun SAP scaffolds in 2D and 3D conditions displayed desirable proliferation, viability, and differentiation in comparison to the gold standard. In vivo biocompatibility assay confirmed the permissibility of implanted fibrous channels by foreign body reaction. The results of this study demonstrated that fibrous 2D/3D electrospun SAP scaffolds, when shaped as micro-channels, can be suitable to support NSC transplantation for regeneration following spinal cord injury. Full article
(This article belongs to the Special Issue Nanofibrous Scaffolds Application in Biomedicine)
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Article
Nanofibrous Polycaprolactone Membrane with Bioactive Glass and Atorvastatin for Wound Healing: Preparation and Characterization
Pharmaceutics 2023, 15(7), 1990; https://doi.org/10.3390/pharmaceutics15071990 - 20 Jul 2023
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Abstract
Skin wound healing is one of the most challenging processes for skin reconstruction, especially after severe injuries. In our study, nanofiber membranes were prepared for wound healing using an electrospinning process, where the prepared nanofibers were made of different weight ratios of polycaprolactone [...] Read more.
Skin wound healing is one of the most challenging processes for skin reconstruction, especially after severe injuries. In our study, nanofiber membranes were prepared for wound healing using an electrospinning process, where the prepared nanofibers were made of different weight ratios of polycaprolactone and bioactive glass that can induce the growth of new tissue. The membranes showed smooth and uniform nanofibers with an average diameter of 118 nm. FTIR and XRD results indicated no chemical interactions of polycaprolactone and bioactive glass and an increase in polycaprolactone crystallinity by the incorporation of bioactive glass nanoparticles. Nanofibers containing 5% w/w of bioactive glass were selected to be loaded with atorvastatin, considering their best mechanical properties compared to the other prepared nanofibers (3, 10, and 20% w/w bioactive glass). Atorvastatin can speed up the tissue healing process, and it was loaded into the selected nanofibers using a dip-coating technique with ethyl cellulose as a coating polymer. The study of the in vitro drug release found that atorvastatin-loaded nanofibers with a 10% coating polymer revealed gradual drug release compared to the non-coated nanofibers and nanofibers coated with 5% ethyl cellulose. Integration of atorvastatin and bioactive glass with polycaprolactone nanofibers showed superior wound closure results in the human skin fibroblast cell line. The results from this study highlight the ability of polycaprolactone-bioactive glass-based fibers loaded with atorvastatin to stimulate skin wound healing. Full article
(This article belongs to the Special Issue Nanofibrous Scaffolds Application in Biomedicine)
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