Gastrointestinal Disease: From Cellular Mechanisms to Targeted Therapy

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 94

Special Issue Editors

National Institute of Gastroenterology “S. De Bellis” Research Hospital, Castellana Grotte, Italy
Interests: microRNA; inflammatory bowel disease; gastrointestinal cancer; intestinal permeability
Special Issues, Collections and Topics in MDPI journals
Department of Biological and Environmental Sciences and Technologies (DeBEST), Università del Salento, Via per Monteroni c/o Ecotekne, 73100 Lecce, Italy
Interests: cell physiology; comparative and applied physiology; cellular homeostasis; transmembrane transport processes/systems; solute carriers (SLC); epithelial physiology; epithelial cell models; oligopeptides; immunity and inflammation; animal models; zebrafish; cytotoxicity; cell–material interactions; biomaterials; tissue engineering; tissue regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The pathophysiology of the GI tract includes a broad range of diseases and processes, from injury and repair to chronic inflammatory states and cancer. In recent years, biomedical research has aimed to characterize and elucidate the cellular mechanisms underlying GI disease progression. New technologies that focus on genomic, transcriptomic, and proteomic aspects allow us to identify the molecular mechanisms that drive disease onset and progression and thus new potential targets for therapy.

This Special Issue will aim to cover novel research exploring all cellular mechanisms, ranging from the induction of apoptosis and autophagy to cell cycle arrest, epithelial turnover, inhibition of epithelial–mesenchymal transition, suppression of cellular invasion and migration, and modulation of multiple signaling pathways in gastrointestinal disease, including cancer, immune disease, and infectious disease. Additionally, this Special Issue will include studies that highlight innovative molecular-based drug targets and their associated predictive biomarkers. Original research articles and reviews are welcome.

Dr. Grazia Serino
Dr. Amilcare Barca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gastrointestinal cancer
  • gastric cancer
  • colorectal cancer
  • esophageal cancer
  • liver cancer
  • pancreatic cancer
  • inflammatory bowel disease
  • miRNAs
  • in vitro and in vivo models
  • molecular networks
  • molecular pathways
  • translational medicine
  • epithelial barrier functions/processes

Published Papers

This special issue is now open for submission.
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