Exploitation of Microbial Metabolites and Novel Approaches of Their Synthesis

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1026

Special Issue Editor

Institute of Food Sciences, Warsaw University of Life Sciences, 02-776 Warsaw, Poland
Interests: lactic acid bacteria; silage microbiology; yeast biotechnology; circular economy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbial metabolites such as antibiotics, pigments, aroma compounds, hormones, drug agents, antimicrobials, antioxidants and enzymes are of great interest due to their huge potential for human life and health. Among the microorganisms producing the above-mentioned compounds, there can be enumerated archeabacteria, bacteria, yeast, molds and algae. Bioactive compounds have their action in small amounts and are still being investigated in medicine, chemistry, food technology and ecology. We hardly know a small percentage of all organisms living on earth. Moreover, we search for so-called extremophiles. These microorganisms can, in contrast to mesophiles, grow under extreme conditions. It can be imagined that such organisms either produce a different range of enzymes than mesophiles, or produce enzymes with extreme characteristics, such as temperature or stability and activity at extreme pH values. Exploiting new microorganisms is not the only way of possessing new metabolites; recombinant DNA techniques may open the door to the application of microbial bioactive compounds. Still, introducing new bioprocessing techniques can be a promising idea to synthesize with higher yield microbial-derived biologically active molecular entities.

This Special Issue welcomes papers addressing the different effects that exposure studies on new microbial metabolites, metabolites already known from newly discovered or engineered cells or microbial metabolites with improved yield by novel methodology of culture.

Dr. Agata Urszula Fabiszewska
Guest Editor

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Keywords

  • microbial metabolites
  • genetic manipulation
  • batch culture
  • novel resources
  • green chemistry

Published Papers (1 paper)

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Research

15 pages, 4346 KiB  
Article
Unconventional Extraction Methods of Oleaginous Yeast Cell Pretreatment and Disruption
Appl. Sci. 2023, 13(24), 13135; https://doi.org/10.3390/app132413135 - 10 Dec 2023
Viewed by 799
Abstract
Extraction is one of the most commonly used methods for obtaining and purifying chemical compounds for commercial usage. The aim of this study was to evaluate the effect of unconventional permeabilization and cell disruption methods on the yield of lipid extraction from cells [...] Read more.
Extraction is one of the most commonly used methods for obtaining and purifying chemical compounds for commercial usage. The aim of this study was to evaluate the effect of unconventional permeabilization and cell disruption methods on the yield of lipid extraction from cells of the oleaginous yeast Yarrowia lipolytica. Batch cultures in a medium with molasses and waste post-frying oil were carried out. The biomass was subjected to pulsed electric field (PEF), high-pressure processing (HPP), ultrasounds (US), and several conventional processing techniques with chemical and mechanical agents (glass beads, acetone, Triton and Tween surfactants). The effectiveness of the applied methods, either on cell permeabilization or cell disruption, was investigated by analyzing the oil and total protein extraction yield and oil leaching efficiency, as well as by using microscope images. The PEF and US treatments proved to be effective permeabilization methods as a step of sample pretreatment for extraction. These unconventional physical methods could efficiently increase intracellular lipid extraction yield in solvent applications. Full article
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