Mitophagy and Oxidative Stress

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 308

Special Issue Editors

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Guest Editor
1. FISABIO–Hospital Universitario Dr. Peset, Valencia, Spain
2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Valencia, Spain
3. Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
Interests: mitochondria; autophagy; type 2 diabetes; oxidative stress; mitophagy; insulin resistance; atherosclerosis
Special Issues, Collections and Topics in MDPI journals
1. Dr. Peset Hospital Research Foundation, Valencia, Spain
2.CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Valencia, Spain
Interests: oxidative stress; obesity; inflammation; endothelial dysfunction; endoplasmic reticulum stress
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46017 Valencia, Spain
Interests: empagliflozin; SGLT2 inhibitors; type 2 diabetes; oxidative stress; inflammation; leukocytes

Special Issue Information

Dear Colleagues,

Over the past few decades, the prevalence of cardiometabolic diseases, including type 2 diabetes mellitus (T2MD), polycystic ovary syndrome (PCOS), obesity, insulin resistance, metabolic syndrome, atherosclerosis, hyperlipidaemia, and hepatic steatosis, has increased dramatically. In this context, reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important secondary messengers within the cells; however, an imbalance between generation of reactive ROS and antioxidant defence systems establishes oxidative stress. Previous studies have found that excessive amounts of ROS being generated could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction, immune activation, and inflammation that are critical for the pathogenesis of metabolic diseases. Underlying molecular mechanisms that lead to cellular dysfunction include mitochondrial impairment, autophagy, mitophagy, endoplasmic reticulum stress, apoptosis, but there is still much to be learned about their mutual interaction and modifications they undergo during metabolic diseases. Furthermore, although the precise molecular mechanisms of mitophagy in diabetes have yet to be fully clarified, recent findings imply that mitophagy improves cardiac function in the heart of a diabetic. However, excessive mitophagy may exacerbate myocardial damage in patients with diabetes. Given the relevance of this topic, it would seem appropriate to summarize some of the main recent advances in research on the role of oxidative stress and underlying molecular mechanisms, especially mitophagy, in the pathogenesis of metabolic diseases and their impact on health, disease, and ageing.

We invite authors to submit original articles and review articles on this interesting topic.

  • Potential topics include, but are not limited, to the following:
  • Role of ROS and oxidative stress in metabolic diseases;
  • Mitochondrial impairment and metabolic diseases;
  • Oxidative stress and autophagy-mitophagy in metabolic diseases;
  • Therapeutic strategies to overwhelmed oxidative stress in metabolic diseases;
  • Mitophagy and oxidative stress;
  • Mitophagy and homeostasis.

Prof. Dr. Victor M. Victor
Dr. Milagros Rocha
Dr. Rovira-Llopis Susana
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mitochondria
  • mitophagy
  • diabetes
  • oxidative stress
  • ROS
  • antioxidants
  • autophagy
  • human
  • cardiometabolic
  • endothelium

Published Papers

There is no accepted submissions to this special issue at this moment.
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