Special Issue "Roles of Vascular Oxidative Stress in the Pathogenesis of Atherosclerosis"
Deadline for manuscript submissions: closed (20 December 2019) | Viewed by 32160
2. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Valencia, Spain
3. Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
Interests: mitochondria; autophagy; type 2 diabetes; oxidative stress; mitophagy; insulin resistance; atherosclerosis
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It is well known that reactive oxygen species (ROS) and oxidative stress are related to the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Atherosclerosis represents a state of exacerbated oxidative stress characterized by protein and lipid oxidation in the vascular endothelium. Similarly, endothelial dysfunction is also characterized by a loss of nitric oxide (NO) bioactivity, which occurs early on in the development of atherosclerosis and can determine the development of future vascular complications. In general, ROS are essential to cell functions, including redox signaling, proliferation of cells, and mitogenesis, and can mimic and amplify the action of growth factors; at the same time, adequate levels of antioxidant defenses are required in order to avoid the harmful effects of excessive ROS production.
Therefore, it is clear that the biological specificity of ROS action depends on the localization, amount, and duration of ROS production. To date, although major ROS-sensitive signal transduction pathways have been shown to be involved in atherosclerosis, there is still much to be learned about their mutual interaction and the modifications they undergo during metabolic and vascular diseases, including type 2 diabetes. Due to the relevance of such topics, it would seem appropriate to summarize some of the main recent advances in research on the role of vascular oxidative stress in the pathogenesis of atherosclerosis and its impact on health, disease and aging.
We invite authors to submit original articles and review articles on this interesting topic.
Potential topics include, but are not limited, to the following:
- Role of ROS in atherosclerosis
- Type 2 diabetes and atherosclerosis
- Signaling pathways of ROS action
- Positive feedback loop in ROS production
- Interaction among cellular sources of ROS production
- New insight into the relationship between oxidative stress and atherosclerosis
- Role of oxidative stress in metabolic, cardiovascular diseases and cancer.
- Vascular oxidative stress and autophagy-mitophagy
- Vascular oxidative stress and reticulum stress
Dr. Victor M Victor
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- Oxidative stress
- Type 2 diabetes