Special Issue "Frontiers in Oxidative Stress and Metabolic Diseases"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 17089
2.CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Valencia, Spain
Interests: oxidative stress; obesity; inflammation; endothelial dysfunction; endoplasmic reticulum stress
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondria; autophagy; type 2 diabetes; oxidative stress; mitophagy; insulin resistance; atherosclerosis
Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus, obesity, metabolic syndrome, and fatty liver diseases, has increased dramatically. Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important second messengers within the cells; however, an imbalance between the generation of reactive ROS and antioxidant defense systems establishes oxidative stress. Previous studies have found that excessive ROS generation is linked to cellular and tissue dysfunction, immune activation, and inflammation that are critical for the pathogenesis of metabolic diseases. Underlying molecular mechanisms leading to oxidative-induced cellular dysfunction include mitochondrial impairment, autophagy, mitophagy, endoplasmic reticulum stress and apoptosis, but there is still much to be learned about their mutual interaction and the modifications they undergo during metabolic diseases. Given the relevance of this topic, it would seem appropriate to summarize some of the main recent advances in the research on the role of oxidative stress and underlying molecular mechanisms in the pathogenesis of metabolic diseases and the new therapeutic strategies to combat their detrimental impact on health, disease and ageing.
Authors are invited to submit both original and review articles related, but not limited, to these interesting topics.
Dr. Milagros Rocha
Dr. Victor M. Victor
Dr. Sandra López-Doménech
Manuscript Submission Information
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- mitochondrial dysfunction
- insulin resistance
- ER stress
- adipose tissue
- pancreatic cells