Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.8
7.0
Journals
Antioxidants
Special Issues
Oxidative Stress in Adipose Tissue
share announcement

Oxidative Stress in Adipose Tissue

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2108

Special Issue Editors

Prof. Dr. Fátima Nogales Bueno

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain
Interests: oxidative stress; antioxidants; selenium; endocrinology; energy metabolism; metabolic syndrome; adipose tissue
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. María Luisa Ojeda Murillo

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain
Interests: oxidative stress; antioxidants; selenium; endocrinology; energy metabolism; metabolic syndrome; insulin resistance; adipose tissue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adipose tissue (AT) is a vital endocrine organ that plays a pivotal role in regulating metabolism, inflammation, energy homeostasis, and thermogenesis. Therefore, this tissue is involved in the appearance of several metabolic syndromes, type 2 diabetes and obesity.  By releasing adipokines, the AT can affect other tissues, communicate with other organs and exert an adverse influence on the development of these metabolic disorders.

Oxidative stress (OS) is involved in the development and function of AT. Physiological reactive oxidive species (ROS) are fundamental to the adipogenic differentiation of white adipocytes and to thermogenesis in brown adipose tissue. However, the excessive accumulation of ROS or inadequate ROS clearance, as a consequence of deficiency or failed antioxidant defenses, provoke AT dysfunction and are strongly associated with obesity and metabolic diseases.

This Special Issue aims to present an overview of the current knowledge regarding the role of OS and antioxidant therapy in maintaining the healthy functioning of AT. Additionally, it will explore the impact of ROS on the pathological mechanisms that contribute to the development of metabolic diseases involving AT. 

Prof. Dr. Fátima Nogales Bueno
Prof. Dr. María Luisa Ojeda Murillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • adipose tissue
  • ROS
  • antioxidant defense

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

22 pages, 863 KiB  
Review
The Role of Adipokines and Myokines in the Pathogenesis of Different Obesity Phenotypes—New Perspectives
by Marta Pelczyńska, Ewa Miller-Kasprzak, Marcin Piątkowski, Roksana Mazurek, Mateusz Klause, Anna Suchecka, Magdalena Bucoń and Paweł Bogdański
Antioxidants 2023, 12(12), 2046; https://doi.org/10.3390/antiox12122046 - 26 Nov 2023
Viewed by 1714
Abstract
Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological [...] Read more.
Obesity is a characteristic disease of the twenty-first century that is affecting an increasing percentage of society. Obesity expresses itself in different phenotypes: normal-weight obesity (NWO), metabolically obese normal-weight (MONW), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). A range of pathophysiological mechanisms underlie the occurrence of obesity, including inflammation, oxidative stress, adipokine secretion, and other processes related to the pathophysiology of adipose tissue (AT). Body mass index (BMI) is the key indicator in the diagnosis of obesity; however, in the case of the NWO and MONW phenotypes, the metabolic disturbances are present despite BMI being within the normal range. On the other hand, MHO subjects with elevated BMI values do not present metabolic abnormalities. The MUO phenotype involves both a high BMI value and an abnormal metabolic profile. In this regard, attention has been focused on the variety of molecules produced by AT and their role in the development of obesity. Nesfatin-1, neuregulin 4, myonectin, irisin, and brain-derived neurotrophic factor (BDNF) all seem to have protective effects against obesity. The primary mechanism underlying the action of nesfatin-1 involves an increase in insulin sensitivity and reduced food intake. Neuregulin 4 sup-presses lipogenesis, decreases lipid accumulation, and reduces chronic low-grade inflammation. Myonectin lowers the amount of fatty acids in the bloodstream by increasing their absorption in the liver and AT. Irisin stimulates the browning of white adipose tissue (WAT) and consequently in-creases energy expenditure, additionally regulating glucose metabolism. Another molecule, BDNF, has anorexigenic effects. Decorin protects against the development of hyperglycemia, but may also contribute to proinflammatory processes. Similar effects are shown in the case of visfatin and chemerin, which may predispose to obesity. Visfatin increases adipogenesis, causes cholesterol accumulation in macrophages, and contributes to the development of glucose intolerance. Chemerin induces angiogenesis, which promotes the expansion of AT. This review aims to discuss the role of adipokines and myokines in the pathogenesis of the different obesity phenotypes. Full article
(This article belongs to the Special Issue Oxidative Stress in Adipose Tissue)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop