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Antioxidants
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Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid...
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Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid and Energy Metabolism-II

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 2123

Special Issue Editors

Prof. Dr. María Luisa Ojeda Murillo

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain
Interests: oxidative stress; antioxidants; selenium; endocrinology; energy metabolism; metabolic syndrome; insulin resistance; adipose tissue
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fátima Nogales Bueno

E-Mail Website
Guest Editor
Department of Physiology, Faculty of Pharmacy, Seville University, 41012 Seville, Spain
Interests: oxidative stress; antioxidants; selenium; endocrinology; energy metabolism; metabolic syndrome; adipose tissue
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The first volume of the Special Issue Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid and Energy Metabolism, has received good citations, especially the publications related to the use of selenium nanoparticles (SeNPs). SeNPs have been reported to have many unique biological activities since they have a wide surface, and are more biologically available with less Se. These characteristics make SeNPs less toxic and highly effective.  

The last Special Issue highlighted the immunomodulatory and metabolic characteristics of SeNPs. Moreover, other important contributions addressed different aspects of Se on adipose tissue as well as obesity, adipose-tissue insulin sensitivity, non-alcoholic fatty liver disease (NAFLD) progression and dyslipidemia. Some of these alterations are described in adults, adolescent and offspring animals, pointing to a correct dietary Se intake as a crucial element to reproductive physiology. In this second release, we welcome papers concerning Se, SeNPs and selenoproteins and their relationship to oxidative stress, growth and lipid and energy metabolism, which could lead to metabolic disorders. 

Prof. María Luisa Ojeda Murillo
Dr. Fátima Nogales Bueno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • selenium nanoparticles
  • Adipose tissue
  • Growth
  • Metabolism
  • Energy
  • Oxidative stress
  • Selenoproteins
  • Insulin resistance
  • Growth hormone
  • Non-alcoholic fatty liver disease.

Published Papers (1 paper)

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Research

23 pages, 2569 KiB  
Article
Microbiota-Liver-Bile Salts Axis, a Novel Mechanism Involved in the Contrasting Effects of Sodium Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Development in Adolescent Rats
by María Luisa Ojeda, Fátima Nogales, José A. Carrasco López, María del Carmen Gallego-López, Olimpia Carreras, Ana Alcudia and Eloísa Pajuelo
Antioxidants 2023, 12(5), 1123; https://doi.org/10.3390/antiox12051123 - 19 May 2023
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Abstract
Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its form of administration (selenite or [...] Read more.
Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its form of administration (selenite or Se nanoparticles (SeNPs). Despite this effect being related to oxidative, insulin-signaling and autophagy processes, the whole mechanism is not elucidated. The microbiota–liver–bile salts secretion axis is related to lipid homeostasis and adipose tissue development. Therefore, the colonic microbiota and total bile salts homeostasis were explored in four experimental groups of male adolescent rats: control, low-sodium selenite supplementation, low SeNP supplementation and moderate SeNPs supplementation. SeNPs were obtained by reducing Se tetrachloride in the presence of ascorbic acid. Supplementation was received orally through water intake; low-Se rats received twice more Se than control animals and moderate-Se rats tenfold more. Supplementation with low doses of Se clearly affected anaerobic colonic microbiota profile and bile salts homeostasis. However, these effects were different depending on the Se administration form. Selenite supplementation primarily affected liver by decreasing farnesoid X receptor hepatic function, leading to the accumulation of hepatic bile salts together to increase in the ratio Firmicutes/Bacteroidetes and glucagon-like peptide-1 (GLP-1) secretion. In contrast, low SeNP levels mainly affected microbiota, moving them towards a more prominent Gram-negative profile in which the relative abundance of Akkermansia and Muribaculaceae was clearly enhanced and the Firmicutes/Bacteroidetes ratio decreased. This bacterial profile is directly related to lower adipose tissue mass. Moreover, low SeNP administration did not modify bile salts pool in serum circulation. In addition, specific gut microbiota was regulated upon administration of low levels of Se in the forms of selenite or SeNPs, which are properly discussed. On its side, moderate-SeNPs administration led to great dysbiosis and enhanced the abundance of pathogenic bacteria, being considered toxic. These results strongly correlate with the deep change in adipose mass previously found in these animals, indicating that the microbiota–liver–bile salts axis is also mechanistically involved in these changes. Full article
(This article belongs to the Special Issue Dietary Selenium and Its Antioxidant Properties Related to Growth, Lipid and Energy Metabolism-II)
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