Special Issue "Natural Antioxidants in Obesity and Related Diseases—2nd Edition"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 10 August 2024 | Viewed by 691

Special Issue Editors

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Soeul 02447, Republic of Korea
Interests: obesity; high-fat diet; brown adipocytes; AMP-activated protein kinase; adipogenesis; thermogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Hyo In Kim
E-Mail Website
Guest Editor
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Interests: cancer; inflammation; antioxidants; immunology; cell metabolism

Special Issue Information

Dear Colleagues,

Obesity is a complex chronic disease defined by excessive adiposity that impairs health. Obesity not only increases the risk of metabolic diseases such as diabetes, cardiovascular diseases, and fatty liver diseases but also produces a chronic inflammatory state which leads to many complications. Recent studies have demonstrated that increased fat deposition in obesity may play a role in, or be a result of, excessive oxidative stress in the body.

Antioxidants derived from nature can modulate oxidative stress. Natural antioxidants are widely distributed in food and medicinal plants. These natural antioxidants exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-obesity, and anti-cancer. The consumption of natural antioxidants can ameliorate oxidative stress-induced damage by inhibiting the oxidative chain reaction via a free radical scavenging process.

Thus, the search for these natural antioxidants will provide an advance in therapeutic interventions for obesity and related diseases. An understanding of the mechanism of action of natural antioxidants in redox modulation could be useful to prevent or develop therapies for obesity and related diseases such as diabetes, cardiovascular diseases, fatty liver diseases, inflammatory diseases, or even cancer.

The first edition of our Special Issue on ‘Natural Antioxidants in Obesity and Related Diseases’ successfully invited seven original papers and five reviews (https://www.mdpi.com/journal/antioxidants/special_issues/GP1Z6Q4A36). Following its success, we are ready to introduce the second Edition.

The aim of this Special Issue "Natural Antioxidants in Obesity and Related Diseases—2nd Edition" is to bring together valuable studies including reviews and original articles on multidisciplinary approaches to obesity, especially by focusing on the antioxidant properties of natural products. We will highlight the molecular mechanisms of antioxidants involved in the prevention of obesity-related diseases.

Dr. Jinbong Park
Dr. Hyo In Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • obesity
  • metabolic diseases
  • cardiovascular diseases
  • fatty liver diseases
  • inflammatory diseases
  • cancer
  • antioxidants
  • oxidative stress
  • natural products
  • phytochemicals

Published Papers (1 paper)

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20 pages, 3863 KiB  
Hepatoprotective Mechanisms Induced by Spinach Methanolic Extract in Rats with Hyperglycemia—An Immunohistochemical Analysis
Antioxidants 2023, 12(11), 2013; https://doi.org/10.3390/antiox12112013 - 17 Nov 2023
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Spinach methanolic extract (SME) has a hepatoprotective effect due to its polyphenolic antioxidants; however, its action in parenchymal (PQ) and non-parenchymal (nPQ) cells remains unknown. This study investigates the hepatoprotective effect of SME on streptozotocin-induced hyperglycemic rats (STZ), focusing on immunohistochemical analyses. Methods [...] Read more.
Spinach methanolic extract (SME) has a hepatoprotective effect due to its polyphenolic antioxidants; however, its action in parenchymal (PQ) and non-parenchymal (nPQ) cells remains unknown. This study investigates the hepatoprotective effect of SME on streptozotocin-induced hyperglycemic rats (STZ), focusing on immunohistochemical analyses. Methods: The extract was prepared, and the total polyphenols and antioxidant activity were quantified. Adult male Wistar rats were divided into four groups (n = 8): normoglycemic rats (NG), STZ-induced hyperglycemic (STZ), STZ treated with 400 mg/kg SME (STZ-SME), and NG treated with SME (SME) for 12 weeks. Serum liver transaminases and lipid peroxidation levels in tissue were determined. The distribution pattern and relative levels of markers related to oxidative stress [reactive oxygen species (ROS), superoxide dismutase-1, catalase, and glutathione peroxidase-1], of cytoprotective molecules [nuclear NRF2 and heme oxygenase-1 (HO-1)], of inflammatory mediators [nuclear NF-κB, TNF-α], proliferation (PCNA), and of fibrogenesis markers [TGF-β, Smad2/3, MMP-9, and TIMP1] were evaluated. Results: SME had antioxidant capacity, and it lowered serum transaminase levels in STZ-SME compared to STZ. It reduced NOX4 staining, and lipid peroxidation levels were related to low formation of ROS. In STZ-SME, the immunostaining for antioxidant enzymes increased in nPQ cells compared to STZ. However, enzymes were also localized in extra and intracellular vesicles in STZ. Nuclear NRF2 staining and HO-1 expression in PQ and nPQ were higher in STZ-SME than in STZ. Inflammatory factors were decreased in STZ-SME and were related to the percentage decrease in NF-κB nuclear staining in nPQ cells. Similarly, TGF-β (in the sinusoids) and MMP-9 (in nPQ) were increased in the STZ-SME group compared to the other groups; however, staining for CTGF, TIMP1, and Smad2/3 was lower. Conclusions: SME treatment in hyperglycemic rats induced by STZ may have hepatoprotective properties due to its scavenger capacity and the regulation of differential expression of antioxidant enzymes between the PQ and nPQ cells, reducing inflammatory and fibrogenic biomarkers in liver tissue. Full article
(This article belongs to the Special Issue Natural Antioxidants in Obesity and Related Diseases—2nd Edition)
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