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AMP-Activated Protein Kinases in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3695

Special Issue Editor

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Soeul 02447, Republic of Korea
Interests: obesity; high-fat diet; brown adipocytes; AMP-activated protein kinase; adipogenesis; thermogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

AMP-activated protein kinase (AMPK) plays an important role in several molecular mechanisms and physiological conditions. AMPK has also been identified in multiple catabolic and anabolic signaling pathways; thus, it is a key enzyme which regulates cellular energy homeostasis, glucose, fatty acid uptake and oxidation. Notably, several diseases are known to be closely related to AMPK levels, including inflammation, cancer and cardiovascular and metabolic diseases. The underlying mechanisms of AMPK in such diseases largely involve a reduction in oxidative stress and inflammatory responses. The functions of AMPK in health and disease are intriguing but still require further research. Recent advances in AMPK research have demonstrated its potential benefits as a target for pharmacological interventions for several diseases.

This Special Issue, entitled “AMP-Activated Protein Kinases in Health and Disease”, welcomes original investigations and comprehensive reviews demonstrating new and advanced research viewpoints on the therapeutic potential of targeting AMPK in maintaining health and treating various diseases.

Dr. Jinbong Park
Guest Editor

Manuscript Submission Information

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Keywords

  • AMPK
  • inflammation
  • cancer
  • cardiovascular diseases
  • metabolic diseases
  • oxidative stress
  • phytochemicals

Published Papers (2 papers)

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Research

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25 pages, 3404 KiB  
Article
The polyHIS Tract of Yeast AMPK Coordinates Carbon Metabolism with Iron Availability
by Kobi J. Simpson-Lavy and Martin Kupiec
Int. J. Mol. Sci. 2023, 24(2), 1368; https://doi.org/10.3390/ijms24021368 - 10 Jan 2023
Cited by 2 | Viewed by 1479
Abstract
Energy status in all eukaryotic cells is sensed by AMP-kinases. We have previously found that the poly-histidine tract at the N-terminus of S. cerevisiae AMPK (Snf1) inhibits its function in the presence of glucose via a pH-regulated mechanism. We show here that in [...] Read more.
Energy status in all eukaryotic cells is sensed by AMP-kinases. We have previously found that the poly-histidine tract at the N-terminus of S. cerevisiae AMPK (Snf1) inhibits its function in the presence of glucose via a pH-regulated mechanism. We show here that in the absence of glucose, the poly-histidine tract has a second function, linking together carbon and iron metabolism. Under conditions of iron deprivation, when different iron-intense cellular systems compete for this scarce resource, Snf1 is inhibited. The inhibition is via an interaction of the poly-histidine tract with the low-iron transcription factor Aft1. Aft1 inhibition of Snf1 occurs in the nucleus at the nuclear membrane, and only inhibits nuclear Snf1, without affecting cytosolic Snf1 activities. Thus, the temporal and spatial regulation of Snf1 activity enables a differential response to iron depending upon the type of carbon source. The linkage of nuclear Snf1 activity to iron sufficiency ensures that sufficient clusters are available to support respiratory enzymatic activity and tests mitochondrial competency prior to activation of nuclear Snf1. Full article
(This article belongs to the Special Issue AMP-Activated Protein Kinases in Health and Disease)
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Review

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15 pages, 323 KiB  
Review
The Role of Natural Products in the Improvement of Cancer-Associated Cachexia
by Yohan Han, Hyo In Kim and Jinbong Park
Int. J. Mol. Sci. 2023, 24(10), 8772; https://doi.org/10.3390/ijms24108772 - 15 May 2023
Cited by 4 | Viewed by 1559
Abstract
The enormous library of natural products and herbal medicine prescriptions presents endless research avenues. However, the lack of research evidence and trials on cancer-induced cachexia limit the therapeutic potential of natural products. Cancer-induced cachexia is a systemic wasting syndrome characterized by continuous body [...] Read more.
The enormous library of natural products and herbal medicine prescriptions presents endless research avenues. However, the lack of research evidence and trials on cancer-induced cachexia limit the therapeutic potential of natural products. Cancer-induced cachexia is a systemic wasting syndrome characterized by continuous body weight loss with skeletal muscle and adipose tissue atrophy. Cancer cachexia is a problem in itself and reduces the quality of life by lessening the treatment efficacy of anticancer drugs. This review summarizes single natural product extracts for cancer-induced cachexia, not compounds derived from natural products and herbal medicine prescriptions. This article also discusses the effect of natural products on cachexia induced by anticancer drugs and the role of AMPK in cancer-induced cachexia. The article included the mice model used in each experiment to encourage researchers to utilize animal models for research on cancer-induced cachexia in the future. Full article
(This article belongs to the Special Issue AMP-Activated Protein Kinases in Health and Disease)
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