New Insights into Applications of Natural Antioxidants in Translational Medicine

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 4524

Special Issue Editor


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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Science, University of Messina, 98122 Messina, Italy
Interests: biochemistry; molecular mechanism; oxidative stress; endometriosis
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Special Issue Information

Dear Colleagues,

Many abiotic stresses induce the overproduction of reactive oxygen species (ROS) in humans and animals. As highly reactive and toxic species, they cause damage to DNA, proteins, carbohydrates, and lipids, thus leading to oxidative stress. This oxidative stress induces damage in cells and tissues, resulting in a large number of diseases. Several compounds with antioxidant properties can neutralize the effects of ROS and prevent the development of many inflammatory pathologies. A number of scientific studies report the varied health benefits of antioxidant supplementation in processes such as inflammation, stress, autophagy, mitophagy and apoptosis.

Therefore, this Special Issue will gather evidence on the effects of antioxidants and antioxidant-rich foods on human health and animal health, and will improve our understanding of their beneficial mechanisms, which in turn may contribute to the prevention of disease and development of novel therapies.

This Special Issue welcomes the submission of original contributions, including experimental studies, observational studies, case reports as well as reviews of published literature exploring and summarizing the effects of antioxidant-rich foods, individual antioxidants, and their metabolites on non-communicable diseases, including cardiovascular diseases, chronic diseases, and neurodegenerative diseases, as well as those related to conditions such as aging, quality of life, pain and sleep disorders.

Dr. Roberta Fusco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant-rich foods
  • molecular mechanisms
  • inflammation
  • autophagy
  • natural compounds
  • non-communicable diseases
  • chronic diseases
  • neuropathic pain
  • aging
  • cancer

Published Papers (2 papers)

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Research

25 pages, 4756 KiB  
Article
Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice
by Rossella Di Raimo, Davide Mizzoni, Massimo Spada, Vincenza Dolo, Stefano Fais and Mariantonia Logozzi
Antioxidants 2023, 12(6), 1169; https://doi.org/10.3390/antiox12061169 - 29 May 2023
Cited by 1 | Viewed by 2018
Abstract
Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits [...] Read more.
Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex®) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (H2O2), compared with mice left untreated after the period of H2O2 administration and mice that received only water during the experimental period. The results showed that Exocomplex® had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex® to the H2O2-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care. Full article
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17 pages, 3896 KiB  
Article
Complex Interplay between Autophagy and Oxidative Stress in the Development of Endometriosis
by Ramona D’Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macrì, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea and Rosanna Di Paola
Antioxidants 2022, 11(12), 2484; https://doi.org/10.3390/antiox11122484 - 17 Dec 2022
Cited by 12 | Viewed by 1926
Abstract
Endometriosis (Endo) is a chronic gynecological disease. This paper aimed to evaluate the modulation of autophagy, oxidative stress and apoptosis with Açai Berries in a rat model of endometriosis. Endometriosis was induced with an intraperitoneal injection of minced uterus tissue from a donor [...] Read more.
Endometriosis (Endo) is a chronic gynecological disease. This paper aimed to evaluate the modulation of autophagy, oxidative stress and apoptosis with Açai Berries in a rat model of endometriosis. Endometriosis was induced with an intraperitoneal injection of minced uterus tissue from a donor rat into a recipient one. The abdominal high-frequency ultrasound (hfUS) analysis was performed at 7 and 14 days from the endometriosis induction to evaluate the growth of the lesion during the experiment. Seven days from the induction, once the lesions were implanted, an Açai Berry was administered daily by gavage for the next seven days. At the end of the experiment, the hfUS analysis showed a reduced lesion diameter in animals given the Açai Berry. A macroscopical and histological analysis confirmed this result. From the molecular point of view, Western blot analyses were conducted to evaluate the autophagy induction. Samples collected from the Endo group showed impaired autophagy, while the Açai Berry administration inhibited PI3K and AKT and ERK1/2 phosphorylation and promoted autophagy by inactivating mTOR. Additionally, Açai Berry administration dephosphorylated ATG1, promoting the activity of the ATG1/ULK1 complex that recruited Ambra1/Beclin1 and Atg9 to promote autophagosome nucleation and LC3II expression. Açai Berry administration also restored mitophagy, which increased Parkin cytosolic expression. The Açai Berry increased the expression of NRF2 in the nucleus and the expression of its downstream antioxidant proteins as NQO-1 and HO-1, thereby restoring the oxidative imbalance. It also restored the impaired apoptotic pathway by reducing BCL-2 and increasing BAX expression. This result was also confirmed by the TUNEL assay. Overall, our results displayed that Açai Berry administration was able to modulate autophagy, oxidative stress and apoptosis during endometriosis. Full article
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