Gut Microbiota and Oxidative Stress

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 2406

Special Issue Editor

Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43537, USA
Interests: gut microbiota; drug metabolism; gut-brain axis; gut-kidney axis

Special Issue Information

Dear Colleagues,

The gut microbiota is crucial in the regulation of the antioxidative state in the host. Oxidative stress is involved in multiple physiological functions; in the context of metabolism, however, the mechanisms for host antioxidation and utilization of oxygen are paradoxical.

This Special Issue aims to focus on knowledge gaps associated with the interplay between gut microbiota and the balance of antioxidation and oxidative stress. Topics of interest include but are not limited to the following themes:

  • The role of microbial metabolites in host oxidative stress;
  • The role of microbiota and microbial metabolites in oxidative-stress-mediated pathological changes in immune system, cardiovascular system, kidney, brain, etc.;
  • Specific bacterial strains and their effects on host oxidative stress responses.

Dr. Tao Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • antioxidation
  • oxidative stress
  • metabolism

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 5162 KiB  
Article
Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells
by Estefanía Caballano-Infantes, Ailec Ho-Plágaro, Carlos López-Gómez, Flores Martín-Reyes, Francisca Rodríguez-Pacheco, Bernard Taminiau, Georges Daube, Lourdes Garrido-Sánchez, Guillermo Alcaín-Martínez, Raúl J. Andrade, Miren García-Cortés, M. Isabel Lucena, Eduardo García-Fuentes and Cristina Rodríguez-Díaz
Antioxidants 2023, 12(4), 818; https://doi.org/10.3390/antiox12040818 - 27 Mar 2023
Cited by 2 | Viewed by 1942
Abstract
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease (NALFD) and drug-induced liver injury (DILI). In this study, we investigated the presence [...] Read more.
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease (NALFD) and drug-induced liver injury (DILI). In this study, we investigated the presence of C. difficile-derived MVs in patients with and without CDI, and analyzed their effects on pathways related to NAFLD and DILI in HepG2 cells. Fecal extracellular vesicles from CDI patients showed an increase of Clostridioides MVs. C. difficile-derived MVs that were internalized by HepG2 cells. Toxigenic C. difficile-derived MVs decreased mitochondrial membrane potential and increased intracellular ROS compared to non-toxigenic C. difficile-derived MVs. In addition, toxigenic C. difficile-derived MVs upregulated the expression of genes related to mitochondrial fission (FIS1 and DRP1), antioxidant status (GPX1), apoptosis (CASP3), glycolysis (HK2, PDK1, LDHA and PKM2) and β-oxidation (CPT1A), as well as anti- and pro-inflammatory genes (IL-6 and IL-10). However, non-toxigenic C. difficile-derived MVs did not produce changes in the expression of these genes, except for CPT1A, which was also increased. In conclusion, the metabolic and mitochondrial changes produced by MVs obtained from toxigenic C. difficile present in CDI feces are common pathophysiological features observed in the NAFLD spectrum and DILI. Full article
(This article belongs to the Special Issue Gut Microbiota and Oxidative Stress)
Show Figures

Figure 1

Back to TopTop