Antioxidant Molecules from Marine Origin: Biotechnological and Industrial Applications

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 12194

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Guest Editor
CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal
Interests: antioxidants; free radicals; inflammation; iNOS; LOX; phlorotannins; carotenoids; phenols; seaweeds; HPLC
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Special Issue Information

Dear Colleagues,

The uniqueness of secondary metabolites produced by marine organisms is widely acknowledged within the scientific community. Even far from folk medicine applications typically known for terrestrial plants, marine organisms have asserted themselves in various fields, such as agriculture and medicine, with considerable bio-economic benefits for different industries. In this regard, while the challenge of marine bioactive compounds supply persists, synthetic methods are being employed along with the application of biotechnological techniques to ensure sufficient quantities to meet needs. The recognized value of marine molecules has also attracted investment into computational tools, to provide information on their biosynthetic pathways, in view of modulating the production of compounds of interest, and expanding their biotechnological and industrial applications. Antioxidants are among the most attractive of them, not only for their direct effect on the pathophysiology of several disorders and diseases, but also for their important industrial and biotechnological applications, from fields as wild as food, cosmetics, and drugs preservatives to packaging material and agricultural applications in view of improving crop production yield.

In this Special Issue, I invite you to submit your latest research findings or original review articles, which will bring together current research, as well as highlight the newest data and critical discussions concerning the industrial and biotechnological applications of marine antioxidants.

I look forward to your contribution.

Dr. Graciliana Lopes
Guest Editor

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Keywords

  • seaweeds
  • microalgae
  • polyphenols
  • carotenoids
  • shelf life
  • cosmetic industry
  • oxidative stress
  • agriculture byproducts
  • commercial applications

Published Papers (4 papers)

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Research

15 pages, 4013 KiB  
Article
Characterization of a Novel Superoxide Dismutase from a Deep-sea Sea Cucumber (Psychoropotes verruciaudatus)
by Yanan Li, Zongfu Chen, Peng Zhang, Feng Gao, Junfeng Wang, Li Lin and Haibin Zhang
Antioxidants 2023, 12(6), 1227; https://doi.org/10.3390/antiox12061227 - 07 Jun 2023
Cited by 1 | Viewed by 1105
Abstract
At present, deep-sea enzymes are a research hotspot. In this study, a novel copper–zinc superoxide dismutase (CuZnSOD) was successfully cloned and characterized from a new species of sea cucumber Psychropotes verruciaudatus (PVCuZnSOD). The relative molecular weight of the PVCuZnSOD monomer is 15 kDa. [...] Read more.
At present, deep-sea enzymes are a research hotspot. In this study, a novel copper–zinc superoxide dismutase (CuZnSOD) was successfully cloned and characterized from a new species of sea cucumber Psychropotes verruciaudatus (PVCuZnSOD). The relative molecular weight of the PVCuZnSOD monomer is 15 kDa. The optimum temperature of PVCuZnSOD is 20 °C, and it maintains high activity in the range of 0–60 °C. It also has high thermal stability when incubated at 37 °C. PVCuZnSOD has a maximum activity of more than 50% in the pH range of 4–11 and a high activity at pH 11. In addition, PVCuZnSOD has strong tolerance to Ni2+, Mg2+, Ba2+, and Ca2+, and it can withstand chemical reagents, such as Tween20, TritonX-100, ethanol, glycerol, isopropanol, DMSO, urea, and GuHCl. PVCuZnSOD also shows great stability to gastrointestinal fluid compared with bovine SOD. These characteristics show that PVCuZnSOD has great application potential in medicine, food, and other products. Full article
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36 pages, 2887 KiB  
Article
Soilless Cultivated Halophyte Plants: Volatile, Nutritional, Phytochemical, and Biological Differences
by Sheila C. Oliveira-Alves, Fábio Andrade, João Sousa, Andreia Bento-Silva, Bernardo Duarte, Isabel Caçador, Miguel Salazar, Elsa Mecha, Ana Teresa Serra and Maria Rosário Bronze
Antioxidants 2023, 12(6), 1161; https://doi.org/10.3390/antiox12061161 - 26 May 2023
Cited by 3 | Viewed by 2219
Abstract
The use of halophyte plants appears as a potential solution for degraded soil, food safety, freshwater scarcity, and coastal area utilization. These plants have been considered an alternative crop soilless agriculture for sustainable use of natural resources. There are few studies carried out [...] Read more.
The use of halophyte plants appears as a potential solution for degraded soil, food safety, freshwater scarcity, and coastal area utilization. These plants have been considered an alternative crop soilless agriculture for sustainable use of natural resources. There are few studies carried out with cultivated halophytes using a soilless cultivation system (SCS) that report their nutraceutical value, as well as their benefits on human health. The objective of this study was to evaluate and correlate the nutritional composition, volatile profile, phytochemical content, and biological activities of seven halophyte species cultivated using a SCS (Disphyma crassifolium L., Crithmum maritimum L., Inula crithmoides L., Mesembryanthemum crystallinum L., Mesembryanthemum nodiflorum L., Salicornia ramosissima J. Woods, and Sarcocornia fruticosa (Mill.) A. J. Scott.). Among these species, results showed that S. fruticosa had a higher content in protein (4.44 g/100 g FW), ash (5.70 g/100 g FW), salt (2.80 g/100 g FW), chloride (4.84 g/100 g FW), minerals (Na, K, Fe, Mg, Mn, Zn, Cu), total phenolics (0.33 mg GAE/g FW), and antioxidant activity (8.17 µmol TEAC/g FW). Regarding the phenolic classes, S. fruticosa and M. nodiflorum were predominant in the flavonoids, while M. crystallinum, C. maritimum, and S. ramosissima were in the phenolic acids. Moreover, S. fruticosa, S. ramosissima, M. nodiflorum, M. crystallinum, and I. crithmoides showed ACE-inhibitory activity, an important target control for hypertension. Concerning the volatile profile, C. maritimum, I. crithmoides, and D. crassifolium were abundant in terpenes and esters, while M. nodiflorum, S. fruticosa, and M. crystallinum were richer in alcohols and aldehydes, and S. ramosissima was richer in aldehydes. Considering the environmental and sustainable roles of cultivated halophytes using a SCS, these results indicate that these species could be considered an alternative to conventional table salt, due to their added nutritional and phytochemical composition, with potential contribution for the antioxidant and anti-hypertensive effects. Full article
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22 pages, 2484 KiB  
Article
Antioxidants in Sunscreens: Which and What For?
by Ana Jesus, Sandra Mota, Ana Torres, Maria T. Cruz, Emília Sousa, Isabel F. Almeida and Honorina Cidade
Antioxidants 2023, 12(1), 138; https://doi.org/10.3390/antiox12010138 - 06 Jan 2023
Cited by 12 | Viewed by 6069
Abstract
Ultraviolet (UV) radiation promotes the generation of reactive oxygen species (ROS) and nitrogen species (RNS), resulting in skin damage. Cosmetic industries have adopted a strategy to incorporate antioxidants in sunscreen formulations to prevent or minimize UV-induced oxidative damage, boost photoprotection effectiveness, and mitigate [...] Read more.
Ultraviolet (UV) radiation promotes the generation of reactive oxygen species (ROS) and nitrogen species (RNS), resulting in skin damage. Cosmetic industries have adopted a strategy to incorporate antioxidants in sunscreen formulations to prevent or minimize UV-induced oxidative damage, boost photoprotection effectiveness, and mitigate skin photoaging. Many antioxidants are naturally derived, mainly from terrestrial plants; however, marine organisms have been increasingly explored as a source of new potent antioxidant molecules. This work aims to characterize the frequency of the use of antioxidants in commercial sunscreens. Photoprotective formulations currently marketed in parapharmacies and pharmacies were analyzed with respect to the composition described on the label. As a result, pure compounds with antioxidant activity were found. The majority of sunscreen formulations contained antioxidants, with vitamin E and its derivatives the most frequent. A more thorough analysis of these antioxidants is also provided, unveiling the top antioxidant ingredients found in sunscreens. A critical appraisal of the scientific evidence regarding their effectiveness is also performed. In conclusion, this work provides an up-to-date overview of the use of antioxidants in commercial sunscreens for a better understanding of the advantages associated with their use in photoprotective formulations. Full article
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14 pages, 24994 KiB  
Article
Analysis of Antioxidant Lipids in Five Species of Dietary Seaweeds by Liquid Chromatography/Mass Spectrometry
by Siddabasave Gowda B. Gowda, Chen Yifan, Divyavani Gowda, Yui Tsuboi, Hitoshi Chiba and Shu-Ping Hui
Antioxidants 2022, 11(8), 1538; https://doi.org/10.3390/antiox11081538 - 08 Aug 2022
Cited by 8 | Viewed by 1993
Abstract
Seaweeds are a good source of bioactive lipids and are known for their nutritional benefits, making them a valuable food source. Despite their dietary significance and nutritional importance, there are limited reports on comprehensive lipidome analysis of lipids with antioxidant properties. Therefore, this [...] Read more.
Seaweeds are a good source of bioactive lipids and are known for their nutritional benefits, making them a valuable food source. Despite their dietary significance and nutritional importance, there are limited reports on comprehensive lipidome analysis of lipids with antioxidant properties. Therefore, this study aimed to compare the lipid profiles of five commonly consumed Japanese dietary seaweeds using non-targeted liquid chromatography/mass spectrometry (LC/MS). A total, of 304 molecular species from four major lipid classes were detected and characterized by MS/MS analysis. Multivariate statistical analysis revealed distinct lipid molecular compositions in kombu and sea mustard compared to hijiki, mozuku, and laver seaweeds. Kombu has been shown to contain large amounts of antioxidants, such as polyunsaturated fatty acids (PUFAs), and a high health promotion index compared to other seaweeds. Hierarchical cluster correlations indicated the predominance of glycerophospholipids (GPs) and glycerolipids (GLs) in sea mustard and kombu. As a result, dietary seaweeds have great potential as antioxidants and health-promoting foods for human consumption due to their high levels of PUFA-rich GPs and GLs. Unsaturated triacylglycerols are predominant in hijiki, whereas other health-beneficial lipids, such as monogalactosyldiacylglycerol and sulfoquinovosyl diacylglycerols, are predominant in sea mustard. This study provides a detailed characterization of lipids and their comparative fingerprints in seaweeds, demonstrating the potential use of dietary seaweeds in biotechnological and industrial applications involving the development of functional food products. Full article
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