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Antioxidants
Special Issues
Natural Antioxidants and Oxidative Stress in Livestock and Poultry
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Natural Antioxidants and Oxidative Stress in Livestock and Poultry

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 729

Special Issue Editors

Dr. Haichong Wu

E-Mail Website
Guest Editor
College of Animal Sciences, Zhejiang University, Hangzhou, China
Interests: inflammation; cell signaling pathway; autophagy; bovine
Prof. Dr. Zhigang Zhang

E-Mail Website
Guest Editor
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
Interests: toxicology; nutrition; metabolism; dairy cows; animals

Special Issue Information

Dear Colleagues,

This Special Issue mainly focuses on research into animal nutrition and metabolic diseases, as well as their pathogenesis and prevention and treatment. Free radicals, antioxidants, and health have become important research topics in animal husbandry. Only by clearing free radicals and enhancing the body's antioxidant capacity can we avoid damage from free radicals to cells and tissues. Natural products contain abundant active ingredients (including iridoid compounds, lignans, phenylpropanoids, flavonoids, polysaccharides, etc.), which play an important role in improving immunity, antioxidation, and other aspects. The extracted components can promote the generation of antioxidant enzymes and enhance the clearance of reactive oxygen species. Scholars studying related content are welcome to submit to this journal.

Dr. Haichong Wu
Prof. Dr. Zhigang Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antioxidants and oxidative stress
  • metabolic diseases
  • nutrition
  • livestock

Published Papers (1 paper)

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Review

18 pages, 3304 KiB  
Review
Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions
by Meng Li, Shusheng Tang, Xinyan Peng, Gaurav Sharma, Shutao Yin, Zhihui Hao, Jichang Li, Jianzhong Shen and Chongshan Dai
Antioxidants 2024, 13(4), 452; https://doi.org/10.3390/antiox13040452 - 11 Apr 2024
Viewed by 584
Abstract
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity and its association with a spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, and [...] Read more.
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity and its association with a spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, and cancer. Lycopene, a lipid-soluble natural carotenoid, has emerged as a potential mitigator of the deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, and reproductive impairment. This protective mechanism operates by reducing oxidative stress, inflammation, and lipid peroxidation, and activating the mitochondrial apoptotic pathway, facilitating the activation of mitochondrial biogenesis, the endogenous antioxidant system, and the nuclear factor erythroid 2-related factor 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) and peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, as well as regulating the activities of cytochrome P450 (CYP450) enzymes. This review provides an overview of the protective effects of lycopene against AFB1 exposure-induced toxicity and the underlying molecular mechanisms. Furthermore, it explores the safety profile and potential clinical applications of lycopene. The present review underscores lycopene’s potential as a promising detoxification agent against AFB1 exposure, with the intent to stimulate further research and practical utilization in this domain. Full article
(This article belongs to the Special Issue Natural Antioxidants and Oxidative Stress in Livestock and Poultry)
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