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Antioxidants
Special Issues
The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease
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The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 3044

Special Issue Editors

Dr. Jinghua Wang

E-Mail Website
Guest Editor
Institute of Bioscience & Integrative Medicine, Daejeon University, 75, Daedeok-aero 176, Seo-gu, Daejeon 35235, Republic of Korea
Interests: chronic liver hepatitis; acute liver injury; NAFLD/MAFLD; hepatic fibrosis/cirrhosis; hepatic carcinoma; liver cancer metastasis; herbal medicine; gut microbiome; metagenomics; bile acid metabolite; oxidative stress; lipid metabolism; biomarkers
Special Issues, Collections and Topics in MDPI journals
Dr. Jayanta Kumar Patra

E-Mail Website
Guest Editor
Research Institute of Integrative Life Sciences, Dongguk University, Goyang-si, Republic of Korea
Interests: antioxidant activity; bioactive compounds; medicinal plants; functional foods; biomolecules; nanobiotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the rapid increase in prevalence and the lack of effective therapeutics, Non-Alcoholic Fatty Liver Disease (NAFLD) directly impacts approximately one-fourth of the global population and is gradually becoming a serious issue. While the precise pathogenesis of NAFLD is still not fully understood, it is widely believed to involve a complex interplay with genetic and various environmental factors. As is well known, excessive oxidative stress can significantly accelerate the progression of the NAFLD by inducing lipid peroxidation, mitochondrial dysfunction, inflammation, endoplasmic reticulum stress, and other related factors. However, there remains a notable gap in extensive research regarding how diverse environmental factors impact the progression of NAFLD through oxidative stress, like gut microbiota, lifestyle, food and beverage, and mental stress. Therefore, this Special Issue, entitled 'The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease', aims to select contributions on the advances in research on oxidative stress and its association with NAFLD. We welcome the submission of original research and review articles addressing etiology, mechanism, diagnosis, treatment, prevention, and prognosis of NAFLD, with a specific focus on oxidative stress. We look forward to your valuable contributions.

Potential topics include, but are not limited to:

  1. Exploring the interaction mechanism between oxidative stress and NAFLD;
  2. Studying how antioxidants attenuate NAFLD in relation to oxidative stress;
  3. Future perspectives for novel antioxidant-associated strategy for NAFLD;
  4. Considering the potential of personalized therapies and diagnostics based on the status of oxidative stress.

Dr. Jinghua Wang
Dr. Jayanta Kumar Patra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • oxidative stress
  • NAFLD
  • MASLD
  • F&B
  • gut microbiota
  • lifestyle

Published Papers (3 papers)

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Research

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16 pages, 1122 KiB  
Article
Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study
by Maria Magdalena Quetglas-Llabrés, Margalida Monserrat-Mesquida, Cristina Bouzas, Silvia García, Emma Argelich, Miguel Casares, Lucía Ugarriza, Isabel Llompart, Josep A. Tur and Antoni Sureda
Antioxidants 2024, 13(4), 480; https://doi.org/10.3390/antiox13040480 - 17 Apr 2024
Viewed by 282
Abstract
Background: The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver. Objectives: To assess the antioxidant status in erythrocytes, plasma, and peripheral blood mononuclear cells (PBMCs) [...] Read more.
Background: The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver. Objectives: To assess the antioxidant status in erythrocytes, plasma, and peripheral blood mononuclear cells (PBMCs) of NAFLD patients following a 24-month lifestyle intervention based on the MedDiet. Adult patients (n = 40; aged 40–60 years) diagnosed with NAFLD by magnetic resonance imaging were divided into two groups based on their adherence to the MedDiet. Consumption was assessed using a validated 143-item semiquantitative Food Frequency Questionnaire. Anthropometrics, biochemistry parameters, intrahepatic fat contents (IFC), antioxidants, and inflammatory biomarkers were measured in plasma and erythrocytes before and after the intervention. Results: After the intervention, body mass index (BMI) and plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-chol), triglycerides, malondialdehyde (MDA), and cytokeratin-18 (CK18) decreased, and high-density lipoprotein cholesterol (HDL-chol) increased. Participants with high adherence to MedDiet showed lower IFC, hepatic enzyme (AST, ALT, and GGT), glycemia, oxidase LDL (oxLDL) plasma levels, and erythrocyte MDA levels. Higher antioxidant activity (erythrocyte catalase-CAT, superoxide dismutase-SOD, glutathione peroxidase-GPx, glutathione reductase-GRd, and total glutathione-GSH as well as PBMCs-CAT gene expression) was observed in these patients, along with a reduction of PBMCs reactive oxygen species production and Toll-like receptor 4 (TLR4) expression. Inverse associations were observed between adherence to the MedDiet and BMI, glycemia, AST, IFC, and CK18 plasma levels and oxLDL, CAT, SOD, and GRd activities in erythrocytes. A significant linear regression was observed between adherence to the MedDiet and antioxidant score. Conclusions: Adherence to the MedDiet is associated with improved plasma and PBMC antioxidant and inflammatory biomarker profiles and high antioxidant defences in erythrocytes. Full article
(This article belongs to the Special Issue The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease)
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23 pages, 11869 KiB  
Article
Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats
by Maitane González-Arceo, Leixuri Aguirre, María Teresa Macarulla, Clàudia Gil-Pitarch, María Luz Martínez-Chantar, María P. Portillo and Saioa Gómez-Zorita
Antioxidants 2024, 13(3), 369; https://doi.org/10.3390/antiox13030369 - 18 Mar 2024
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Abstract
Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the [...] Read more.
Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the aim of the present study is to assess the effect of Gracilaria vermiculophylla red seaweed dietary supplementation on hepatic lipid accumulation, as well as on oxidative stress, inflammation and fibrosis- related markers on obese fa/fa Zucker rats fed with a standard diet, supplemented or not with 2.5% or 5% dehydrated Gracilaria vermiculophylla. After a six-week supplementation with the macroalga, no significant reduction in hepatic total lipid content or hepatic triglyceride content was observed. However, both doses were able to diminish hepatic NEFA concentration by reducing de novo lipogenesis and increasing mitochondrial biogenesis. Moreover, supplementation with the dose of 2.5% improved some oxidative stress and inflammation-related markers. Supplementation with the dose of 5% did not exert these clear beneficial effects. Thus, this study demonstrates that while Gracilaria vermiculophylla may not mitigate hepatic steatosis, it could exert protective effects on the liver by reducing NEFA content and enhancing oxidative stress and inflammation parameters. Full article
(This article belongs to the Special Issue The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease)
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Review

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20 pages, 1360 KiB  
Review
Roles of Traditional and Next-Generation Probiotics on Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH): A Systematic Review and Network Meta-Analysis
by Yuezhi Zhu, Jen Kit Tan, Jia Liu and Jo Aan Goon
Antioxidants 2024, 13(3), 329; https://doi.org/10.3390/antiox13030329 - 07 Mar 2024
Viewed by 1146
Abstract
Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal role in managing NAFLD/NASH. [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that the gut microbiome is associated with the pathogenesis of NAFLD/NASH, prompting microbiome-targeted therapy to emerge as a new therapeutic option for NAFLD/NASH. We conducted a systematic review based on the PRISMA statement and employed network meta-analysis to investigate the effects of traditional probiotics and next-generation probiotics (NGPs) on NAFLD/NASH. Comparative analysis reveals that traditional probiotics primarily reduce liver fat deposition and inflammation by improving gut microbiota composition, enhancing intestinal barrier function, and modulating immune responses. In contrast, NGPs demonstrate a more significant therapeutic potential, attributed to their direct effects on inhibiting oxidative stress and their ability to enhance the production of short-chain fatty acids (SCFAs), NGPs appear as a new potential strategy for the management of NAFLD/NASH through their dual action of directly inhibiting oxidative stress and enhancing SCFA production, highlighting the importance of understanding and utilizing the direct and indirect regulatory mechanisms of oxidative stress in the management of NAFLD/NASH. Full article
(This article belongs to the Special Issue The Role of Oxidative Stress in Non-Alcoholic Fatty Liver Disease)
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